5- (2-Fluorophenyl) -1H-Pyrrole-3-Carbaldehyde CAS 881674-56-2 Vonoprazan Fumarate Intermediate Ọcha ≥99.0%
Nyefee Vonoprazan Fumarate na Intermediate emetụtara
5- (2-Fluorophenyl) pyrrole-3-Carboxaldehyde CAS 881674-56-2
Pyridine-3-Sulfonyl Chloride CAS 16133-25-8
Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2
| Aha Chemical | 5- (2-Fluorophenyl) -1H-Pyrrole-3-Carbaldehyde |
| Ụdị okwu | Vonoprazan Fumarate (TAK-438) Nke etiti 3 |
| Nọmba CAS | 881674-56-2 |
| Nọmba CAT | RF-PI330 |
| Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
| Usoro ihe omimi | C11H8FNO |
| Ibu molekụla | 189.19 |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta |
| Ọdịdị | Yellow ruo Brown ntụ ntụ |
| Ebe Na-agbaze | 122.0 ~ 131.0 ℃ |
| njirimara: RT(HPLC) | Dabaa n'ụkpụrụ ntụaka |
| Ọnwụ na ihicha | ≤0.50% |
| Ihe fọdụrụ na mgbanye | ≤0.50% |
| Ihe ndị emetụtara | |
| Ịdị ọcha | ≥99.0% |
| Ọdịghị ọcha ọ bụla | ≤0.50% |
| Mgbakọta adịghị ọcha | ≤1.0% |
| Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
| Ojiji | Ọkara nke Vonoprazan Fumarate (TAK-438) (CAS 881681-01-2) |
ngwugwu: Kalama, Aluminom foil bag, kaadiboodu drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe pụọ na ọkụ, mmiri mmiri na ọrịa nje.
5- (2-Fluorophenyl) -1H-Pyrrole-3-Carbaldehyde (CAS 881674-56-2) na-arụ ọrụ dị ka reagent na nkwadebe sịntetik nke ihe ndị na-emepụta pyrrole ọhụrụ dị ka potassium-competitive acid blocker (P-CAB).5- (2-Fluorophenyl) pyrrole-3-Carboxaldehyde bụ etiti nke Vonoprazan Fumarate (CAS 1260141-27-2).Vonoprazan fumarate (Takecab®), nke Takeda na Otsuka chọtara ma mepụta, PMDA nke Japan kwadoro na Disemba 2014, a na-egosikwa ya maka ọgwụgwọ ọnya afọ, ọnya duodenal na reflux esophagitis.Vonoprazan fumarate nwere usoro ihe omume nke a na-akpọ potassium-competitive acid blockers, bụ nke na-egbochi njikọ nke ion potassium na H +, K+-ATPase (nke a makwaara dị ka mgbapụta proton) na njedebe ikpeazụ nke secretion acid gastric na cell parietal gastric.Vonoprazan anaghị egbochi ọrụ Na +, K+-ATPase ọbụna na mkpokọta 500 ugboro dị elu karịa nke ụkpụrụ IC50 ha megide gastric H +, K+-ATPase ọrụ.Ọzọkwa, ọgwụ ahụ adịghị emetụta steeti secretory gastric, n'adịghị ka PPI.
