5-Fluorocytosine (5-FC) CAS 2022-85-7 Ịdị ọcha ≥99.5% (HPLC) Capecitabine Emtricitabine Intermediate Factory

5-Fluorocytosine (5-FC) CAS: 2022-85-7 Usoro nyocha
Ọdịdị-Ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha kristal ntụ ntụ
Ọnwụ na ihicha-Hichaa ya na 105 maka awa 4: ọ na-efunahụ ihe karịrị 1.50% nke ibu ya.
Ihe fọdụrụ na mgbanye - ọ bụghị ihe karịrị 0.1%.
Ọla dị arọ - ọ bụghị karịa 0.002%.
Fluoride-Mix 70 mL nke ngwọta potassium chloride nke a kwadebere ọhụrụ na 30 ml nke mmanya isopropyl, jupụta electrode na ihe na-egbuke egbuke, ma kwe ka electrode nọrọ na ngwakọta maka ihe na-erughị awa 2 tupu eji ya, ma ọ bụ ọkachamma n'abali.
Mgbe ị na-atụle nha, bufee ihe ngwọta na beaker 150-mL, ma mikpuo electrodes.Fanye mmanya na-akpali akpali nke nwere polytef n'ime beaker, tinye beaker n'elu ihe ndọta nke nwere ihe mkpuchi dị n'elu, ma kwe ka ọ kpalie ruo mgbe a ga-enweta nha anya (ihe dịka nkeji 1 ruo 2).Sachaa ma kpoo electrodes n'etiti nha, na-elezi anya ka ị ghara ịcha kristal n'ime electrode ion kpọmkwem.
Tulee ike nke nkwadebe Ọkọlọtọ ọ bụla, wee chepụta mkpokọta fluoride, na mg kwa 100 ml, karịa ike, na mV, na mpempe akwụkwọ semilogarithmic.Tulee ikike nkwadebe nke nnwale ahụ, wee chọpụta site na usoro ọkọlọtọ na mkpokọta fluoride, na mg kwa 100 ml.Gbakọọ pasent nke fluoride na mpaghara Flucytosine nke usoro a were were:
C/10
N'ime nke C bụ mkpokọta fluoride, na mg kwa 100 ml, site na usoro ọkọlọtọ: ọ bụghị ihe karịrị 0.05% nke fluoride ka achọtara.
Fluorouracil-gbari 250 mg na 10 ml nke ngwakọta nke glacial acetic acid na mmiri (4: 1).Tinye 20 µL nke ngwọta a na efere chromatographic nke dị nro nke ejiri akwa 0.5-mm nke ngwakọta silica gel chromatographic kpuchiri.N'otu efere ahụ tinye 20 µL, na 10-µL increments, nke 0.025 mg kwa mL ngwọta nke USP Fluorouracil RS na ngwakọta nke glacial acetic acid na mmiri (4: 1).Mepụta chromatogram na ngwakọta nke chloroform na glacial acetic acid (13: 7) ruo mgbe ihe mgbaze n'ihu akwagharịghị ihe na-erughị 14 cm site na mmalite.Wepu efere ahụ site na ụlọ na-emepe emepe, ma kwe ka ihe mgbaze na-ekpochapụ.Chọta ntụpọ dị na efere ahụ site na ilele anya n'okpuru radieshon UV dị mkpụmkpụ: ntụpọ ọ bụla sitere na ngwọta n'okpuru ule adịghị ukwuu na nha na ike karịa ebe dị na RF dị iche iche nke Standard Solution mepụtara, dabara na ọ bụghị ihe karịrị 0.1% nke fluorouracil.
Assay-Ebe ihe dị ka 400 mg nke Flucytosine, nke a tụrụ nke ọma, na beaker 250-mL, tinye 150 ml nke ngwakọta nke 2 mpịakọta glacial acetic acid na 1 olu nke acetic anhydride, na igbari, na-ekpo ọkụ nwayọọ ma ọ bụrụ na ọ dị mkpa.Titrate nwere ike iji 0.1 N perchloric acid VS, na-eji sistemụ eletrọd calomel-glass.Mee mkpebi efu, ma mee mgbazi ọ bụla dị mkpa.Otu ml nke 0.1 N perchloric acid bụ 12.91 mg nke C4H4FN3O.Flucytosine nwere ọ bụghị ihe na-erughị pasent 98.5 na ọ bụghị karịa 101.0 pasent nke C4H4FN3O, gbakọọ na ntọala akpọnwụwo.