6-Iodoindazole CAS 261953-36-0 Ịdị ọcha> Ụlọ ọrụ 98.5% (HPLC)
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Aha Chemical | 6-Iodoindazole |
Ụdị okwu | 6-Iodo (1H) indazole;6-Iodo-1H-Indazole |
Nọmba CAS | 261953-36-0 |
Nọmba CAT | RF2672 |
Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
Usoro ihe omimi | C7H5IN2 |
Ibu molekụla | 244.04 |
Ebe Na-agbaze | 207.0 ruo 211.0 ℃ |
Ebe esi nri | 358.2 ± 15.0 ℃ |
Njupụta | 2.082±0.06 g/cm3 |
Mmetụta | Ìhè nwere mmetụta, mmetụta ikuku |
Solubility | DMSO (obere), methanol (obere) |
Ụdị | Ruifu Chemical |
Ihe | Nkọwapụta |
Ọdịdị | Yellow siri ike |
1H NMR Spectrum | Nkwekọrịta na Ọdịdị |
Mass | Dabara |
Ụzọ ịdị ọcha / nyocha | > 98.5% (HPLC) |
Ebe Na-agbaze | 207.0 ruo 211.0 ℃ |
Ọnwụ na ihicha | <0.50% |
Mgbakọta adịghị ọcha | <1.50% |
Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
Ojiji | Isi etiti nke njikọ nke Axitinib (CAS: 319460-85-0) |
ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ
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Ihe atụ?Ọtụtụ ngwaahịa na-enye ihe nlele efu maka nyocha dị mma, ndị ahịa kwesịrị ịkwụ ụgwọ mbupu.
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Synthesis omenala?Nwere ike ịnye ọrụ nhazi ahaziri iche ka ọ dabara mkpa nyocha gị nke ọma.
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A na-eji 6-Iodoindazole (CAS: 261953-36-0) dị ka ndị na-ahụ maka ọgwụ.6-Iodoindazole bụ isi etiti nke njikọ nke Axitinib (CAS: 319460-85-0).Jenụwarị 27, 2012, FDA kwadoro axitinib maka ọgwụgwọ ọrịa kansa akụrụ dị elu (renal cell carcinoma) nke ọgwụ ndị ọzọ na-azaghị.Pfizer na-arụpụta Inlyta ma na-ere ya, ọ bụkwa ọgwụ ọnụ na-aṅụ ugboro abụọ n'ụbọchị.Renal cell carcinoma bụ ụdị etuto si na sel endothelial tubular.Axitinib nwere ike igbochi ụfọdụ protein a na-akpọ kinases na-ekere òkè na uto tumo na metastasis.Axitinib bụ obere molecule tyrosine kinase inhibitor, dị irè megide ọtụtụ ebumnuche, gụnyere ndị na-anabata VEGF 1, 2 na 3. Axitinib bụ VEGFR inhibitor (IC50s = 1.2, 0.25, na 0.29 nM maka VEGFR1, -2, na -3, n'otu n'otu) .