7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2 Ịdị Ọcha>99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

Nkọwa dị mkpirikpi:

Aha: 7-Chloro-6-Nitro-4-Hydroxyquinazoline

Ọkụ: 53449-14-2

Dị ọcha:> 99.0% (HPLC)

Ọdịdị: Ìhè Yellow ka Light Brown ntụ ntụ

Nke etiti Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

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Nkọwa ngwaahịa

Ngwaahịa ndị emetụtara

Mkpado ngwaahịa

Nkọwa:

Ruifu Chemical Supply Intermediates of Afatinib
Afatirib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino) acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H) -otu CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S) -N4- (3-Chloro-4-Fluorophenyl) -7-((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N- (3-Chloro-4-Fluorophenyl) -6-Nitro-7-((Tetrahydrofuran-3-yl) oxy) quinazolin-4-AmineCAS 314771-88-5

Njirimara kemịkalụ:

Aha Chemical	7-Chloro-6-Nitro-4-Hydroxyquinazoline
Ụdị okwu	7-Chloro-4-Hydroxy-6-Nitroquinazoline;7-Chloro-6-Nitro-4-Quinazolinol;7-Chloro-6-Nitro-4-Quinazolinone;7-Chloro-6-Nitro-4 (3H) - Quinazolinone;7-Chloro-6-Nitro-3,4-Dihydroquinazolin-4-otu;7-Chloro-6-Nitroquinazolin-4(3H) -otu
Nọmba CAS	53449-14-2
Nọmba CAT	RF-PI2030
Ọnọdụ Ahịa	N'ọkwa, Mpụta Ihe ruru Tọn
Usoro ihe omimi	C8H4ClN3O3
Ibu molekụla	225.59
Mmetụta	Okpomọkụ nwere mmetụta
Solubility	Soluble ntakịrị na Dimethylformamide
Ụdị	Ruifu Chemical

Nkọwapụta:

Ihe	Nkọwapụta
Ọdịdị	Agba odo ka ọ bụrụ ntụ ntụ ntụ ntụ ntụ
njirimara (HPLC)	Oge njide nke nlele kwesịrị dakọtara na ọkọlọtọ
Ụzọ ịdị ọcha / nyocha	> 99.0% (HPLC)
Ebe Na-agbaze	300.0 ~ 303.0 ℃
Ọdịnaya Mmiri (KF)	<0.50%
Ihe fọdụrụ na mgbanye	<0.30%
adịghị ọcha 1	<0.50% (7-Chloro-4-Hydroxyquinazoline CAS: 31374-18-2)
adịghị ọcha 2	<0.50% (5,7-Dichloro-4[1H] quinazolinone)
adịghị ọcha 3	<1.00% (7-Chloro-8-Nitro-4[1H] quinazolinone)
Ndị ọzọ Otu adịghị ọcha	<0.20%
Mgbakọta adịghị ọcha	<1.00%
Ọla dị arọ (dị ka Pb)	<20ppm
Spectrum infrared	Dabara na Ọdịdị
Ọnụ ego nke Proton NMR Spectrum	Ọnụ ego nke Proton NMR Spectrum
Nlele ọkọlọtọ	Standardkpụrụ ụlọ ọrụ
Ojiji	Nke etiti Afatinib, Afatinib Dimaleate

Ngwungwu & Nchekwa:

ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ

Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri

Uru:

Ajụjụ:

Ngwa:

7-Chloro-6-Nitro-4-Hydroxyquinazoline (CAS: 53449-14-2) bụ etiti nke Afatinib Dimaleate (CAS: 850140-73-7).Afatinib bụ ezinụlọ ErbB na-enweghị ike ịgbanwe agbanwe nke na-egbochi nnyefe ozi ma gbochie ụzọ ndị bụ isi na-etinye aka na uto cell na nkewa.N'ihi na usoro ntụgharị ozi ezinụlọ ErbB nwere ike ịkpalite site na ọtụtụ homodimers na heterodimers, mgbochi nke ọtụtụ ndị ezinaụlọ ErbB n'otu oge (dị ka EGFR, HER2, ErbB3 na ErbB4) nwere ike kwụsịtụ ntugharị ozi ala nke ọma.A na-eji Afatinib agwọ otu ụdị ọrịa kansa akpa ume (na-abụghị obere cell cancer) nke gbasaara n'akụkụ ndị ọzọ nke ahụ.Ọ bụ nke otu ọgwụ a maara dị ka kinase inhibitors.Ọ na-arụ ọrụ site n'ibelata ma ọ bụ kwụsị itolite mkpụrụ ndụ kansa.Ọ na-ejikọta na ụfọdụ protein (epidermal receptor-EGFR) na ụfọdụ etuto ahụ.