7-Fluoro-6-Nitroquinazolin-4(1H) -otu CAS 162012-69-3 Ịdị ọcha>99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

Nkọwa dị mkpirikpi:

Aha Chemical: 7-Fluoro-6-Nitroquinazolin-4(1H) -otu

OZI: 162012-69-3

Dị ọcha:> 99.0% (HPLC)

kristal edo edo ka ọ na-acha ọbara ọbara ma ọ bụ ntụ ntụ

Nke etiti Afatinib Dimaleate (CAS: 850140-73-7)

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E-Mail: alvin@ruifuchem.com

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Nkọwa:

Ruifu Chemical Supply Intermediates of Afatinib
Afatirib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino) acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H) -otu CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S) -N4- (3-Chloro-4-Fluorophenyl) -7-((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N- (3-Chloro-4-Fluorophenyl) -6-Nitro-7-((Tetrahydrofuran-3-yl) oxy) quinazolin-4-AmineCAS 314771-88-5

Njirimara kemịkalụ:

Aha Chemical	7-Fluoro-6-Nitroquinazolin-4(1H) -otu
Ụdị okwu	7-Fluoro-6-Nitroquinazolin-4 (3H) -otu;7-Fluoro-4-Hydroxy-6-Nitroquinazoline;7-Fluoro-6-Nitroquinazolin-4-ol;7-Fluoro-6-Nitro-4-Hydroxyquinazoline;7-Fluoro-6-Nitro-1H-Quinazolin-4-otu
Nọmba CAS	162012-69-3
Nọmba CAT	RF-PI2025
Ọnọdụ Ahịa	N'ọkwa, Mpụta Ihe ruru Tọn
Usoro ihe omimi	C8H4FN3O3
Ibu molekụla	209.13
Ụdị	Ruifu Chemical

Nkọwapụta:

Ihe	Nkọwapụta
Ọdịdị	kristal edo edo ka ọ na-acha ọbara ọbara ma ọ bụ ntụ ntụ
1 H NMR Spectrum	Nkwekọrịta na Ọdịdị
Ụzọ ịdị ọcha / nyocha	> 99.0% (HPLC)
Ọnwụ na ihicha	<0.50%
Mgbakọta adịghị ọcha	<1.00%
Ọnụ ego nke Proton NMR Spectrum	Dabara na Ọdịdị
Nlele ọkọlọtọ	Standardkpụrụ ụlọ ọrụ
Ojiji	Nke etiti Afatinib Dimaleate (CAS: 850140-73-7)

Ngwungwu & Nchekwa:

ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ

Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri

Uru:

Ajụjụ:

Ngwa:

7-Fluoro-6-Nitroquinazolin-4 (1H) -otu (CAS: 162012-69-3) bụ etiti nke Afatinib Dimaleate (CAS: 850140-73-7).Afatinib bụ ezinụlọ ErbB na-enweghị ike ịgbanwe agbanwe nke na-egbochi nnyefe ozi ma gbochie ụzọ ndị bụ isi na-etinye aka na uto cell na nkewa.N'ihi na usoro ntụgharị ozi ezinụlọ ErbB nwere ike ịkpalite site na ọtụtụ homodimers na heterodimers, mgbochi nke ọtụtụ ndị ezinaụlọ ErbB n'otu oge (dị ka EGFR, HER2, ErbB3 na ErbB4) nwere ike kwụsịtụ ntugharị ozi ala nke ọma.Afatinib bụ ọgwụ akwadoro maka ọgwụgwọ carcinoma na-abụghị obere cell lung (NSCLC), nke Boehringer Ingelheim mepụtara.Ọ na-arụ ọrụ dị ka ihe mgbochi angiokinase.Dị ka lapatinib na neratinib, afatinib bụ tyrosine kinase inhibitor (TKI) nke na-egbochikwa onye na-anabata ihe na-eto eto epidermal 2 (Her2) na epidermal growth factor receptor (EGFR) kinases.Afatinib abụghị naanị na-arụsi ọrụ ike megide mmụgharị EGFR nke ọgbọ mbụ TKIs likeerlotinib ma ọ bụ gefitinib gbadoro anya, kamakwa megide ndị na-adịghị emetụta usoro ọgwụgwọ ọkọlọtọ ndị a.N'ihi ihe mgbakwunye ya megide Her2, a na-enyocha ya maka ọrịa kansa ara yana ọrịa EGFR na Her2 ndị ọzọ na-ebute.