7-Methoxy-1-Naphthylacetonitrile CAS 138113-08-3 Ịdị Ọcha>99.0% (HPLC) Agomelatine Intermediate
Onye isi na-emepụta ihe na onye na-eweta Aomelatine Intermediates
Agomelatine CAS 138112-76-2
7-Methoxy-1-Tetralone CAS 6836-19-7
7-Methoxy-1-Naphthaleneacetic Acid CAS 6836-22-2
7-Methoxy-1-Naphthylacetonitrile CAS 138113-08-3
7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester CAS 6836-21-1
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| Aha Chemical | 7-Methoxy-1-Naphthylacetonitrile |
| Ụdị okwu | 7-Methoxy-1-Naphthylmethylcyanide;7-Methoxy-1-Naphthaleneacetinitrile;1-cyanomethyl-7-Methoxynaphthalene;2- (7-Methoxy-1-Naphthyl) acetonitrile;2- (7-Methoxynaphthalen-1-yl) acetonitrile;Agomelatine adịghị ọcha 12;Agomelatine etiti 1 |
| Nọmba CAS | 138113-08-3 |
| Nọmba CAT | RF2504 |
| Ọnọdụ Ahịa | N'ahịa, Ikike Mmepụta Tọn 30 kwa ọnwa |
| Usoro ihe omimi | C13H11NO |
| Ibu molekụla | 197.24 |
| Ebe Na-agbaze | 83.0 ruo 86.0 ℃ |
| Njupụta | 1.135±0.06 g/cm3 |
| Ntụgharị ntụgharị n20/D | 1.44 |
| Solubility | Soluble na methanol |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta |
| Ọdịdị | Ntụ ntụ edo edo dị ọkụ |
| Ụzọ ịdị ọcha / nyocha | > 99.0% (HPLC) |
| Ebe Na-agbaze | 83.0 ~ 86.0 ℃ |
| Ọnwụ na ihicha | <0.50% |
| Ihe fọdụrụ na mgbanye | <0.20% |
| Otu adịghị ọcha | <0.50% |
| Mgbakọta adịghị ọcha | <1.00% |
| Ọla dị arọ | <20ppm |
| Ọnụ ego nke Proton NMR Spectrum | Dabara na Ọdịdị |
| Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
| Ojiji | Ndị n'etiti ọgwụ;Agomelatine Intermediate |
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Uru?Ogo dị oke mma, ọnụ ahịa dị ọnụ ala, ọrụ ọkachamara na nkwado teknụzụ, nnyefe ngwa ngwa.
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Ihe atụ?Ọtụtụ ngwaahịa na-enye ihe nlele efu maka nyocha dị mma, ndị ahịa kwesịrị ịkwụ ụgwọ mbupu.
Nyocha ụlọ ọrụ?Nnabata nyocha ụlọ ọrụ.Biko mee oge oge tupu oge eruo.
MOQ?Enweghị MOQ.A na-anabata obere usoro.
Oge Mbuga ozi? Ọ bụrụ n'ime ngwaahịa, ekwenyere nnyefe ụbọchị atọ.
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Synthesis omenala?Nwere ike ịnye ọrụ nhazi ahaziri iche ka ọ dabara mkpa nyocha gị nke ọma.
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7-Methoxy-1-Naphthylacetonitrile (CAS: 138113-08-3) bụ etiti nke Agomelatine (CAS: 138112-76-2).Agomelatine, nke ụlọ ọrụ French Servier mepụtara, bụ ndị na-anabata melatonin mbụ n'ụwa MT1 na MT2 agonist nke antidepressants.Agomelatine na-emetụta ọgwụgwọ nke ndị okenye nwere nnukwu nkụda mmụọ.Agomelatine bụ antidepressant ọhụrụ nwere omume agonist nhọrọ na ndị na-anabata melatonin yana nhọrọ antagonist nhọrọ na ndị na-anabata serotonin 5HT-2C.Ọ naghị emetụta nnabata nke serotonin, noradrenaline ma ọ bụ dopamine.Agomelatine nwere ike inye aka ịhazi elekere ahụ gị (circadian rhythm) nwere uru dị mma na ọnọdụ na ịda mbà n'obi na-ehi ụra Aomelatine na-eji ọgwụgwọ ịda mbà n'obi ma ọ bụ nyere aka gbochie ịda mbà n'obi ịlaghachi, ma dị naanị ya na ndenye ọgwụ.Agomelatine - Ọrịa Uche ọzọ "blockbuster" klas ọgwụ.Agomelatine nwere antidepressant, mgbochi nchekasị, na-edozi ụda ụra na ịhazi ọrụ nke elekere ndu, na mmeghachi omume ọjọọ ya, ịrụ ọrụ mmekọahụ na-enweghị mmetụta ọjọọ, na enweghị nzaghachi nkwụsị.Agomelatine nwere mmetụta dị mma na ndị ọrịa nwere ịda mbà n'obi, na mmeghachi omume ọjọọ dị ntakịrị.Usoro ọgwụgwọ akwadoro maka Agomelatine bụ 25mg kwa ụbọchị n'ime ọkara elekere tupu ịrahụ ụra.
