S-Adenosyl-L-Methionine (Ademetionine; SAME) CAS 29908-03-0
Ruifu Chemical bụ onye na-emepụta S-Adenosyl-L-Methionine (Ademetionine; SAME) (CAS: 29908-03-0) nwere oke mma.Ruifu Chemical nwere ike ịnye nnyefe zuru ụwa ọnụ, ọnụahịa asọmpi, ọrụ magburu onwe ya, obere na nnukwu ọnụọgụ dị.Ịzụta S-Adenosyl-L-Methionine,Please contact: alvin@ruifuchem.com
| Aha Chemical | S-Adenosyl-L-Methionine |
| Ụdị okwu | Ademetionine;S-Adenosylmethionine;SAME;SAM;AdoMet |
| Ọnọdụ Ahịa | Na ngwaahịa, Mmepụta Azụmahịa |
| Nọmba CAS | 29908-03-0 |
| Usoro ihe omimi | C15H22N6O5S |
| Ibu molekụla | 398.44 g/mol |
| Ebe Na-agbaze | 267.0 ~ 269.0 ℃ |
| Mmetụta | Ezigbo hygroscopic |
| Mmiri Solubility | Soluble na Mmiri |
| Isi & uto | Njirimara |
| COA & MSDS | Dị |
| Ihe atụ | Dị |
| Mmalite | Shanghai, China |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta | Nsonaazụ |
| Ọdịdị | Ihe fọrọ nke nta ka ọ bụrụ ntụ ntụ dị ọcha (Nnọọ Hygroscopic) | Ekwenyere |
| Solubility | Soluble na Mmiri | |
| njirimara | 1. mmeghachi omume chemical | Mmeghachi omume ziri ezi |
| 2. IR: N'ikwekọ na ụdịdị dị iche iche enwetara na RS | Ekwenyere | |
| 3. Oge njide nke nnukwu ọnụ ọgụgụ na-ezute arịrịọ | Ekwenyere | |
| Uru acid | 1.5-2.5 | 1.9 |
| Ịdị ọcha na agba nke ngwọta | Agbaghị nke ukwuu karịa RS Y1 | Ekwenyere |
| Mmiri nke Karl Fischer | ≤3.00% | 2.2% |
| Ihe fọdụrụ na mgbanye | ≤0.30% | 0.14% |
| Ọla dị arọ (Pb) | ≤10ppm | <10ppm |
| Endotoxin | ≤0.3EU/mg | Ekwenyere |
| Microbiological | Kwesịrị imezu ihe a chọrọ | |
| Ngụkọta ọnụ ọgụgụ efere | ≤1000cfu/g | 55cfu/g |
| Yist & ebu | ≤100cfu/g | 12cfu/g |
| E. Coli | Adịghị/10g | Na-akwado |
| S. Aureus | Adịghị/10g | Na-akwado |
| Salmonella | Adịghị/10g | Na-akwado |
| S-Adenosyl-L-Homocysteine | ≤0.50% | 0.10% |
| Meththioadenosine | ≤1.00% | 0.24% |
| Adenin | ≤0.50% | 0.09% |
| Ihe ndị emetụtara | ||
| Ihe adịghị ọcha ndị ọzọ kacha ukwuu | ≤0.20% | 0.01% |
| Mgbakọta adịghị ọcha ndị ọzọ | ≤0.50% | 0.006% |
| (S,S) Isomer | > 62.0% | 79.4% |
| Butanedisulfonate | 46.0 ~ 49.0% (Dabere na akpọnwụwo) | 47.5% |
| Ademetionine | 50.0 ~ 53.0% (Dabere na akpọnwụwo) | 52.1% |
| mkpokọta ọdịnaya | > 97.5% (Dabere na akpọnwụwo) | 99.6% |
| Mmechi | A nwalela ngwaahịa a wee kwado nkọwa ndị enyere | |
| Ndụ shelf | Afọ 2 mgbe echekwara nke ọma | |
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Koodu HS 293499909
S-Adenosyl-L-Methionine (Ademetionine; SAME) (CAS: 29908-03-0) bụ ihe jikọrọ ọnụ na-etinye aka na mbufe otu methyl.Achọpụtara SAME na Italy nke GL Cantoni na 1952, SAME bụ molecule nke mkpụrụ ndụ niile dị ndụ na-emepụta mgbe niile, nwere ike igbochi kansa imeju, ịkwalite anụ ahụ cartilaginous na-akpụpụta na nnabata, nwere ike inye aka ịlụ ọgụ ịda mbà n'obi, ọrịa alzheimer, ọrịa imeju, na mgbu. Osteoarthritis, SAME bụ ugbu a na-anabata ụwa dị ka ọgwụ dị mkpa maka ịgwọ ọrịa imeju.Ugbu a SAME na-ejikarị na ọgwụ, ụlọ ọrụ nri nlekọta ahụike ma n'ahịa ụlọ na mba ụwa.A na-ere SAME na United States dịka mgbakwunye nri.
1. S-Adenosyl-L-Methionine bụ ezigbo nri maka imeju, nke nwere ike igbochi mmanya na-aba n'anya, ọgwụ ọjọọ na imeju cell mmebi;
2. S-Adenosyl-L-Methionine nwere mmetụta mgbochi dị ịrịba ama na ịba ọcha n'anya na-adịghị ala ala na ihe ndị ọzọ na-akpata mmebi imeju, ọrịa obi, ọrịa cancer na ihe ndị ọzọ.
3. Achọpụtala S-Adenosyl-L-Methionine dị irè dị ka ọgwụ maka ịgwọ ọrịa ogbu na nkwonkwo na nnukwu ịda mbà n'obi.
4. Na United States, a na-ere SAM dị ka ihe mgbakwunye nri n'okpuru aha ahịa SAM-e (nke a na-asụkwa SAME ma ọ bụ SAME).Ụfọdụ nnyocha egosiwo na ịṅụ SAM mgbe nile nwere ike inyere aka ịlụso ịda mbà n'obi, ọrịa imeju, na mgbu ogbu na nkwonkwo ọgụ.Ọtụtụ ule ụlọ ọgwụ egosila na ọ dị mma maka ịda mbà n'obi, ụfọdụ ọrịa imeju na osteoarthritis.Emebeghi akara ngosi ndị ọzọ niile.
5. Clinically eji mee ka ọrụ imeju dịkwuo mma.Nchikota ya na L-DOPA maka ọgwụgwọ ọrịa Parkinson nwere ike imeziwanye arụmọrụ L-dopa ma belata mmetụta.Enwere ike ịhụ mgbu mpaghara, nchekasị na-adịru nwa oge na ehighị ụra nke ọma na saịtị injection.
S-Adenosyl-L-Methionine (Ademetionine; SAME) (CAS: 29908-03-0) nwekwara mmetụta ọgwụgwọ dị mma na ọrịa ogbu na nkwonkwo, akwara fibrous, migraine na ọrịa ndị ọzọ, ma nwee obere mmetụta.N'ihe dị ka afọ 1970, a na-eji SAME eme ihe dị ka ọgwụ ndenye ọgwụ maka ọrịa ogbu na nkwonkwo na Europe.N'afọ 1999, US FDA kwadoro SAME dị ka ngwaahịa ahụike ma ghọọ otu n'ime ngwaahịa oriri na-edozi ahụ kacha mma na United States.
A na-akwado S-Adenosyl-L-Methionine site na njikọ kemịkalụ, gbaa ụka na mgbanwe enzymatic.Usoro gbaa ụka bụ ịgbakwunye precursor L-Methionine na isi ihe nwere isi mmalite C na N, enwere ike nweta nnukwu S-Adenosylmethionine site n'ịzụlite mkpụrụ ndụ microbial.Nke a bụ ugbu a isi ụzọ maka mmepụta mmepụta nke S-Adenosylmethionine.N'ime ha, enwere ike nweta microorganisms eji mee ihe maka ịgba ụka site na nyocha ma ọ bụ usoro nhazi nhazi, nke edere n'ọtụtụ isiokwu na patent n'ụlọ na ná mba ọzọ.Ụfọdụ ọmụmụ enyela usoro nkwadebe nke S-adenosylmethionine, na-eji polyhydroxy organic reagents iji chebe ọrụ nke enzyme, na-eji adenosine triphosphate precursor, L-Methionine na phosphate ions dị ka mkpụrụ, glucose ma ọ bụ / na maltose dị ka ndị na-enye ume, na-agbakwunye ihe mejupụtara. nke ion ígwè, na iji ụdị mmepụta ihe na-emepụta ihe na-emepụta ihe na-eme ka mmepụta nke S-Adenosylmethionine na sel dum.Iji ihe mejupụtara nke ion metal na-ahazi usoro metabolic iji meziwanye ike nke njikọta nke onwe, na-agbakwunye reagents organic iji kpuchido ọrụ nke nje bacteria na enzymes, na-eji ụdị mmepụta permeable iji kwadebe S-Adenosylmethionine, belata oge njikọ, na mee ka ngwaahịa ahụ gbakọta n'èzí cell, nke nwere ike ịchekwa ọnụ ahịa nkewa na-esote ma mee ka usoro ọrụ dị mfe.
Ozi gbasara nchekwa ogologo oge nke S-Adenosyl-L-Methionine nwere oke n'ihi na ndị sonyere na ọtụtụ ọmụmụ na-ewere ya naanị obere oge.Otú ọ dị, n'otu nnyocha nke ọrịa imeju metụtara mmanya na-aba n'anya, ndị sonyere were S-Adenosyl-L-methionine maka afọ 2;N'ime ọmụmụ ihe ahụ, ọnweghị mmetụta dị njọ nke a kọrọ.
Ndị nwere ọrịa bipolar (ọrịa nke mgbanwe ọnọdụ uche, site na ịda mbà n'obi ruo mania) ekwesịghị ịṅụ SAME maka mgbaàmà ịda mbà n'obi ma e wezụga n'okpuru nlekọta nke onye nlekọta ahụike n'ihi na SAME nwere ike ime ka mgbaàmà nke mania dịkwuo njọ.
Ọ bụ ezie na ejirila S-Adenosyl-L-Methionine na-agwọ cholestasis n'oge ime ime, ewepụtabeghị nchekwa ya n'oge ime ime.
SAME nwere ike ibelata mmetụta levodopa (L-dopa), ọgwụ eji agwọ ọrịa Parkinson.Ọ ga-ekwe omume na SAME nwere ike iji ọgwụ na ihe mgbakwunye nri na-emekọrịta ihe nke na-abawanye ọkwa nke serotonin (kemịkalụ nke mkpụrụ ndụ akwara na-emepụta), dị ka antidepressants, L-tryptophan, na St. John's wort.
Enwere nchebara echiche gbasara iji SAME site n'aka ndị mmadụ na-egbochi ọrịa (dị ka ndị nwere nje HIV).Ndị mmadụ na-arịa ọrịa na-adịghị ahụkebe nọ n'ihe ize ndụ maka ọrịa Pneumocystis carinii, na SAME na-akwalite uto nke microorganism a.
Mmetụta ndị SAME na-adịghị ahụkebe, na mgbe ha mere, ha na-abụkarị obere nsogbu dịka ọgbụgbọ ma ọ bụ mgbakasị nri.
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