Afatinib CAS 439081-18-2 Ịdị Ọcha>99.5% (HPLC) Foto egosipụtara

Afatinib CAS 439081-18-2 Ịdị ọcha> Ụlọ ọrụ 99.5% (HPLC)

Nkọwa dị mkpirikpi:

Aha Chemical: Afatirib

Ndị otu: BIBW2992

Nọmba: 439081-18-2

Dị ọcha:> 99.5% (HPLC)

Ọdịdị: Gbanyụọ-Ọcha ntụ ntụ

E-Mail: alvin@ruifuchem.com

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Nkọwa:

Ruifu Chemical Supply Intermediates of Afatinib
Afatirib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino) acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H) -otu CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S) -N4- (3-Chloro-4-Fluorophenyl) -7-((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N- (3-Chloro-4-Fluorophenyl) -6-Nitro-7-((Tetrahydrofuran-3-yl) oxy) quinazolin-4-AmineCAS 314771-88-5

Njirimara kemịkalụ:

Aha Chemical	Afatirib
Ụdị okwu	BIBW2992;BIBW-2992;BIBW2992 Ebe efu;Tomtovok;(S, E) - N- (4- (3-Chloro-4-Fluorophenylamino) -7- (Tetrahydrofuran-3-yloxy) quinazolin-6-yl) -4- (Dimethylamino) ma-2-Enamide
Nọmba CAS	439081-18-2
Nọmba CAT	RF-PI2033
Ọnọdụ Ahịa	N'ọkwa, Mpụta Ihe ruru Tọn
Usoro ihe omimi	C24H25ClFN5O3
Ibu molekụla	485.94
Solubility	Soluble na DMSO
Njupụta	1.380
Ụdị	Ruifu Chemical

Nkọwapụta:

Ihe	Nkọwapụta
Ọdịdị	Gbanyụọ-Ọcha ntụ ntụ
njirimara	HPLC, NMR
Ụzọ ịdị ọcha / nyocha	> 99.5% (HPLC)
Ebe Na-agbaze	100.0 ~ 102.0 ℃
Ọnwụ na ihicha	<0.50%
Ihe fọdụrụ na mgbanye	<0.20%
Mgbakọta adịghị ọcha	<0.50%
Ọla dị arọ	≤20ppm
Ọnụ ego nke NMR Spectrum	Dabara na Ọdịdị
Nlele ọkọlọtọ	Standardkpụrụ ụlọ ọrụ
Ndụ shelf	Ọnwa 24 ma ọ bụrụ na echekwara ya nke ọma
Ojiji	API;Afatirib;Afatinib Dimaleate;NSCLC

Ngwungwu & Nchekwa:

ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ

Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri

Uru:

Ajụjụ:

Ngwa:

Afatinib, nke a makwaara dị ka BIW-2992, (CAS: 439081-18-2) bụ ọgbọ nke abụọ nwere ike na nke na-adịghị agbanwe agbanwe nke onye na-anabata ihe na-eto eto epidermal (EGFR) na onye na-anabata ihe na-eto eto 2 (HER2) tyrosine kinase, nke Boehringer Ingelheim, Germany mepụtara.Ọ nwere ike igbochi ọrụ nke tyrosine kinase n'ụzọ na-enweghị atụ site na ịmeghachi mmeghachi omume Michael na thiol otu cysteine na ọnọdụ 797 nke EGFR.Na Julaị 12, 2013, ọ ghọrọ ọgwụ ọhụrụ maka ọrịa cancer akpa ume na-egbochi obere cell nke US FDA kwadoro n'okpuru aha ahia Gilotrif.Ọgwụ a bụ mbadamba nkume.A na-eji ya maka ọgwụgwọ nke ndị ọrịa chọpụtara na ọrịa cancer akpa ume na-abụghị obere cell (NSCLC) na mfu nke 19th exon ma ọ bụ L858R mutation na 21th exon nke tumor epidermal growth factor receptor (EGFR) kwadoro site na iji ngwa ahụ kwadoro. nke FDA.Ọgwụ ahụ dịkwa irè n'ịgwọ ndị ọrịa HER2 nwere ọrịa kansa ara dị elu.Afatinib bụ nke otu ọgwụ a maara dị ka ihe mgbochi tyrosine kinase.Emebere ndị na-egbochi Tyrosine kinase iji gbochie ọrụ nke otu enzyme a na-akpọ tyrosine kinase.Enzyme a na-ekere òkè dị ukwuu na ọrụ nke mkpụrụ ndụ, ma na-arụsi ọrụ ike n'ịkwalite uto na ọganihu tumor.Afatinib na-arụ ọrụ iji gbochie ọrụ nke ụdị abụọ nke tyrosine kinases: epidermal growth factor receptor (EGFR) na Her2, nke ọtụtụ ụdị ọrịa cancer na-egosipụta.Site n'igbochi ọrụ nke tyrosine kinases ndị a, Afatinib nwere ike igbochi mkpụrụ ndụ kansa kewaa na itolite.