Afatinib Dimaleate Intermediate CAS 314771-76-1 Ịdị Ọcha>99.0% (HPLC) Foto egosipụtara

Afatinib Dimaleate Intermediate CAS 314771-76-1 Ịdị ọcha> Ụlọ ọrụ 99.0% (HPLC)

Nkọwa dị mkpirikpi:

Aha Chemical: (S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine

Nọmba: 314771-76-1

Dị ọcha:> 99.0% (HPLC)

Ọdịdị: Ìhè odo na-acha odo odo ntụ ntụ

Nke etiti Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

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Nkọwa:

Ruifu Chemical Supply Intermediates of Afatinib
Afatirib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino) acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H) -otu CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S) -N4- (3-Chloro-4-Fluorophenyl) -7-((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N- (3-Chloro-4-Fluorophenyl) -6-Nitro-7-((Tetrahydrofuran-3-yl) oxy) quinazolin-4-AmineCAS 314771-88-5

Njirimara kemịkalụ:

Aha Chemical	(S) -N4- (3-Chloro-4-Fluorophenyl) -7-((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-Diamine
Ụdị okwu	N4- (3-Chloro-4-Fluorophenyl) -7-[[(3S) -Tetrahydro-3-Furanyl] oxy] -4,6-Quinazolinediamine;Afatinib adịghị ọcha B;Afatinib-des (4-Dimethylamino-2-en-1-oxo)butyl;Des (4-Dimethylamino-2-en-1-oxo)butyl Afatinib
Nọmba CAS	314771-76-1
Nọmba CAT	RF-PI2028
Ọnọdụ Ahịa	N'ahịa, Ikike Mmepụta 100MT/Afọ
Usoro ihe omimi	C18H16ClFN4O2
Ibu molekụla	374.8
Ebe esi nri	559.0± 50.0 ℃
Njupụta	1.473±0.060 g/cm3
Ụdị	Ruifu Chemical

Nkọwapụta:

Ihe	Nkọwapụta
Ọdịdị	Icha odo odo na ntụ ntụ odo
njirimara	Oge njide nke ọnụ ọgụgụ kacha elu na HPLC kwesịrị ikwekọ na ọkọlọtọ
Ụzọ ịdị ọcha / nyocha	> 99.0% (HPLC)
Ọnwụ na ihicha	<0.50%
Ihe fọdụrụ na mgbanye	<0.20%
Otu adịghị ọcha	<0.50%
Mgbakọta adịghị ọcha	<1.00%
Ọla dị arọ (dị ka Pb)	≤20ppm
Nlele ọkọlọtọ	Standardkpụrụ ụlọ ọrụ
Ojiji	Nke etiti Afatinib Dimaleate (CAS: 850140-73-7)

Ngwungwu & Nchekwa:

ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ

Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri

Uru:

Ajụjụ:

Ngwa:

(S) -N4- (3-Chloro-4-Fluorophenyl) -7- ((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-Diamine (CAS: 314771-76-1) bụ etiti nke Afatinib Dimaleate. (CAS: 850140-73-7).Afatinib bụ ọgbọ nke abụọ nwere ike na nke a na-apụghị ịgbagha agbagha nke onye na-anabata ihe na-emepụta ihe na-eto eto (EGFR) na mmadụ 2 (HER2) tyrosine kinase, nke Boehringer Ingelheim, Germany mepụtara.Ọ nwere ike igbochi ọrụ nke tyrosine kinase n'ụzọ na-enweghị atụ site na ịmeghachi mmeghachi omume Michael na thiol otu cysteine na ọnọdụ 797 nke EGFR.Ọrụ: 1. Dị ka Lapatinib na Neratinib, Afatinib bụ protein kinase inhibitor nke na-egbochikwa ihe na-eme ka mmadụ na-eto eto 2 (Her2) na epidermal growth factor receptor (EGFR) kinases.2. Afatinib abụghị naanị na-arụsi ọrụ ike megide mgbanwe EGFR nke ezubere iche maka ọgbọ mbụ TKI dị ka erlotinib ma ọ bụ gefitinib, kamakwa megide mmụgharị dị ka T790M nke na-adịghị emetụta usoro ọgwụgwọ ndị a.N'ihi ihe mgbakwunye ya megide Her2, a na-enyocha ya maka ọrịa kansa ara yana ọrịa EGFR na Her2 ndị ọzọ na-ebute.3. Afatinib bụ ọgwụ maka ọgwụgwọ mbụ nke ndị ọrịa nwere ụdị metastatic dị iche iche (EGFR mutation positive) na-abụghị obere cell lung carcinoma (NSCLC).Ọ na-arụ ọrụ dị ka onye na-egbochi covalent nke na-anabata tyrosine kinases epidermal growth factor receptor (EGFR) na erbB-2 (HER2).