Apixaban CAS 503612-47-3 ịdị ọcha ≥99.5% (HPLC)
Shanghai Ruifu Chemical Co., Ltd bụ onye na-emepụta Apixaban (CAS: 503612-47-3) nwere oke mma.Ruifu Chemical nwere ike ịnye nnyefe zuru ụwa ọnụ, ọnụahịa asọmpi, ọrụ magburu onwe ya, obere na nnukwu ọnụọgụ dị.Ịzụta Apixaban,Please contact: alvin@ruifuchem.com
| Aha Chemical | Apixaban |
| Ụdị okwu | 1- (4-Methoxyphenyl) -7-oxo-6-[4- (2-oxopiperidin-1-yl) phenyl] -4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c] pyridine -3-carboxamide, 4,5,6,7-Tetrahydro-1- (4-methoxyphenyl) -7-oxo-6-[4- (2-oxo-1-piperidinyl) phenyl] -1H-pyrazolo [3, 4-c] pyridine-3-carboxamide, BMS 562247, BMS-562247 |
| Ọnọdụ Ahịa | Na ngwaahịa, Mmepụta Azụmahịa |
| Nọmba CAS | 503612-47-3 |
| Usoro ihe omimi | C25H25N5O4 |
| Ibu molekụla | 459.51 g/mol |
| Ebe Na-agbaze | 235.0 ~ 238.0 ℃ |
| Njupụta | 1.42 |
| COA & MSDS | Dị |
| Mmalite | Shanghai, China |
| Otu | API |
| Ụdị | Ruifu Chemical |
| Ihe | Ụkpụrụ nyocha | Nsonaazụ |
| Ọdịdị | Ntụ ntụ kristal na-acha ọcha ruo na-agbanyụọ | Na-akwado |
| Ọnwụ na ihicha | ≤0.50% | 0.10% |
| Ihe fọdụrụ na mgbanye | ≤0.10% | 0.08% |
| Ọla dị arọ (dị ka Pb) | ≤20ppm | Na-akwado |
| Ihe ndị emetụtara | ||
| Ọdịghị ọcha ọ bụla | ≤0.50% | Na-akwado |
| Mgbakọta adịghị ọcha | ≤0.50% | Na-akwado |
| Ụzọ ịdị ọcha / nyocha | ≥99.5% (HPLC) | 99.9% |
| Spectrum infrared | Dabara na Ọdịdị | Na-akwado |
| 1 H NMR Spectrum | Dabara na Ọdịdị | Na-akwado |
| Mmechi | A nwalela ngwaahịa a wee kwado nkọwapụta | |
ngwugwu:Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Debe akpa ahụ nke ọma ma chekwaa n'ebe dị jụụ, kpọrọ nkụ (2 ~ 8 ℃) yana ụlọ nkwakọba ihe nke ọma na-esi na ihe ndị na-adabaghị adaba.Chebe site na ìhè na mmiri mmiri.
Mbupu:Jiri ikuku na-ebuga ụwa niile site na FedEx / DHL Express.Nye nnyefe ngwa ngwa na ntụkwasị obi.
Ọ nweghị ngwaahịa a ga-enye mba ndị nke a nwere ike megidere ikike ikike dị ugbu a.Agbanyeghị, ọrụ ikpeazụ dị n'aka onye zụrụ ya.
Maka iji nyocha sayensị naanị, ọ bụghị maka ebumnuche azụmahịa ọ bụla, ọ bụghị maka mmadụ ma ọ bụ nyocha nyocha.
Kedu ka esi azụta?Biko kpọtụrụDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Ahụmịhe afọ 15?Anyị nwere ihe karịrị 15 afọ nke ahụmahụ na mmepụta na mbupụ nke a dịgasị iche iche nke elu mma pharmaceutical intermediates ma ọ bụ ezi kemịkal.
Isi ahịa?Na-ere ahịa ụlọ, North America, Europe, India, Korea, Japanese, Australia, wdg.
Uru?Ogo kachasị elu, ọnụ ahịa dị ọnụ ala, ọrụ ọkachamara na nkwado teknụzụ, nnyefe ngwa ngwa.
OgoNkwenye?Usoro njikwa mma siri ike.Ngwá ọrụ ọkachamara maka nyocha gụnyere NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, wdg.
Ihe atụ?Ọtụtụ ngwaahịa na-enye ihe nlele efu maka nyocha dị mma, ndị ahịa kwesịrị ịkwụ ụgwọ mbupu.
Nyocha ụlọ ọrụ?Nnabata nyocha ụlọ ọrụ.Biko mee oge oge tupu oge eruo.
MOQ?Enweghị MOQ.A na-anabata obere usoro.
Oge Mbuga ozi? Ọ bụrụ n'ime ngwaahịa, ekwenyere nnyefe ụbọchị atọ.
Ụgbọ njem?Site Express (FedEx, DHL), nke ikuku, site n'oké osimiri.
Akwụkwọ?Mgbe ọrụ ahịa gasịrị: COA, MOA, ROS, MSDS, wdg nwere ike ịnye.
Synthesis omenala?Nwere ike ịnye ọrụ nhazi ahaziri iche ka ọ dabara mkpa nyocha gị nke ọma.
Usoro ịkwụ ụgwọ?A ga-ebu ụzọ ziga akwụkwọ ọnụahịa Proforma mgbe nkwenye nke iwu, kpuchiri ozi ụlọ akụ anyị.Ịkwụ ụgwọ site na T/T (Telex Nyefee), PayPal, Western Union, wdg.
Apixaban (CAS: 503612-47-3) bụ ụdị ọhụrụ nke ọgwụ mgbochi ọnụ nke Bristol Myers Squibb na Pfizer mepụtara.Ọ bụ ụdị ọhụrụ nke inhibitor Xa factor inhibitor, na aha azụmahịa ya bụ Eliquis.A na-eji Apixaban na-agwọ ndị ọrịa toro eto na-ahọrọ ịwa ahụ n'úkwù ma ọ bụ ikpere iji gbochie thromboembolism venous (VTE)
Apixaban (CAS: 503612-47-3) bụ onye na-eme ihe na-eme ihe na-eme ihe na-eme ka ọnụ na-eme ihe na-eme ka ọ ghara igbochi thrombin ọgbọ na thrombosis.
Apixaban (CAS: 503612-47-3) bụ nke atọ ọhụrụ anticoagulant ọnụ na-aga na-ere, na-eso dabigatran na rivaroxaban, na ọ na-ama na Europe maka igbochi venous thromboembolism na ndị ọrịa na-ahọrọ hip ma ọ bụ ikpere n'ịwa ịwa ahụ dochie.N'ime ọgwụ mgbochi ọnụ atọ a kwadoro na Europe, ma e jiri ya tụnyere usoro ọgwụgwọ mgbochi ugbu a megide thromboembolism venous, enoxaparin, rivaroxaban na-eme nke ọma na nyocha ndekọ, na apixaban na-eme nke ọma na nnwale mbụ.Mmetụta ọgwụgwọ Rivaroxaban dị elu karịa, mana ọ kpatara ọbara ọgbụgba siri ike karịa apixaban.Ndị nchọpụta kwuru na ọdịiche ndị a bụ oge ọgwụ, dịka a na-ewere rivaroxaban 6-8 awa mgbe a wachara ya ahụ na nyocha ndekọ, ebe a na-eji apixaban mee ihe 18 awa mgbe ịwachara ahụ na nyocha mbụ.Ọgwụ ndị a na-enwe mmetụta ọgwụgwọ ka mma ma ọ bụrụ na ejiri ya nso oge ịwa ahụ, mana ha nwekwara nnukwu ihe ize ndụ ọbara ọgbụgba.Nnyocha ụlọ ọgwụ gosiri na atụnyere ọgwụ mgbochi subdermal kwa ụbọchị nke 40mg enoxaparin, 2 oral 2.5mg dosages nke apixaban nwere mmetụta mgbochi ka mma megide thromboembolism venous na-esochi ịwa ahụ ngbanwe hip ma ọ bụ ikpere ma ghara ịbawanye ihe ize ndụ ọbara ọgbụgba.
Apixaban (CAS: 503612-47-3) bụ ụdị ọhụrụ nke inhibitor Xa factor inhibitor nke Bristol-Myers Squibb na Pfizer mepụtara.Aha ahia a bu eratol, nke bu udi ohuru nke anticoagulant onu.Site na igbochi ihe dị mkpa coagulation factor Xa, apixaban nwere ike igbochi mmepụta thrombin na thrombosis.Na Eprel 26, 2007, Bristol-Myers Squibb sonyeere Pfizer aka ikwusa nkwado na mmepe nke apixaban ọhụrụ anticoagulant nke Bristol-Myers Squibb nwere dị ka ihe nkwalite ọzọ na warfarin.Dị ka nkwekọrịta imekọ ihe ọnụ si dị, Pfizer ga-akwụ ụgwọ mbụ nke US $ 0.25 ijeri na Bristol-Myers Squibb iji buru 60% nke ngụkọta mmepe nke apixaban anticoagulant (a ga-emejuputa ya site na Jenụwarị 1, 2007), ebe Bristol-Myers. Squibb ga-ebu 40% fọdụrụnụ, si otú a na-enweta ikike ijikọ mmepụta na ire ọgwụ ahụ.Na May 2011, apixaban bụ onye mbụ kwadoro mgbochi nke thrombosis venous na ndị ọrịa toro eto na-ahọrọ ịwa ahụ n'úkwù ma ọ bụ ikpere na mba 27 EU, Iceland na Norway.Na Nọvemba 20, 2012, European Commission kwadoro Ererto (apixaban) maka igbochi ọrịa strok na usoro embolism na ndị okenye na-arịa ọrịa na-adịghị valvular atrial fibrillation (NVAF) na otu ma ọ bụ karịa ihe ize ndụ.N'ikpeazụ, ndị nchịkwa nri na ọgwụ ndị Canada, Japan, na US FDA kwadoro Ererto?(apixaban) maka mgbochi nke ọrịa strok na usoro embolism nke ndị okenye na-arịa ọrịa na-abụghị valvular atrial fibrillation (NVAF) nwere otu ma ọ bụ karịa ihe ize ndụ.N'April 12, 2013, a mara ọkwa ọkwa ọgwụ ọhụrụ anticoagulant Eloto (ELIQUIS)(apixaban) nke Bristol-Myers Squibb na Pfizer mebere na China.Ererto bụ ihe na-egbochi ọnụ Xa inhibitor maka mgbochi nke venous thromboembolism (VTE) n'ime ndị ọrịa toro eto na-anata ngbanwe hip ma ọ bụ ikpere.Ndepụta ya na-enye nhọrọ ọhụrụ dị mma ma dị irè maka ọgwụ mgbochi ọrịa ọgwụ mgbe a wachara ahụ ọkpụkpụ, ma na-ewetara ndị ọrịa China na-eme mgbanwe mgbanwe hip / ikpere.Nnyocha ụlọ ọgwụ ekwenyela na ma e jiri ya tụnyere 40mg enoxaparin otu ugboro n'ụbọchị, ugboro abụọ kwa ụbọchị nchịkwa ọnụ nke eratol?(apixaban) 2.5mg dị irè karị maka igbochi thromboembolism venous mgbe ịwa ahụ dochie hip ma ọ bụ ikpere, ọ dịghịkwa abawanye ohere nke ọbara ọgbụgba.Ọnụọgụ 1 na-egosi mbadamba Elotoapixaban nke Bristol-Myers Squibb na Pfizer mepụtara.
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