Atazanavir Sulfate CAS 229975-97-7 Dị Ọcha ≥99.0% API Ụlọ ọrụ Anti-HIV HIV-1 Protease Inhibitor
Nye ya na ịdị ọcha dị elu yana ịdị mma kwụsie ike
Aha Chemical: Atazanavir Sulfate
CAS: 229975-97-7
Onye na-egbochi nje HIV-1
API Ogo dị elu, mmepụta azụmahịa
Aha Chemical | Atazanavir sulfate |
Ụdị okwu | BMS-232632 sulfate |
Nọmba CAS | 229975-97-7 |
Nọmba CAT | RF-API71 |
Ọnọdụ Ahịa | Na Akụrụngwa, Mpụta Ihe ruru narị narị kilograms |
Usoro ihe omimi | C38H52N6O7.H2SO4 |
Ibu molekụla | 802.93 |
Ebe Na-agbaze | 195.0-198.0 ℃ |
Solubility | Nke a na-esighi ike na mmiri, Soluble na DMSO |
Nchekwa ogologo oge | Na-echekwa ogologo oge na -20 ℃ |
Ụdị | Ruifu Chemical |
Ihe | Nkọwapụta |
Ọdịdị | Ọcha ma ọ bụ Gbanyụọ-Ọcha ntụ ntụ |
Sulfate | 12.0 ~ 12.5% |
Ọnwụ na ihicha | ≤0.50% |
Ihe fọdụrụ na mgbanye | ≤0.10% |
Ọla dị arọ | ≤20ppm |
Otu adịghị ọcha | ≤0.30% |
Mgbakọta adịghị ọcha | ≤1.0% |
Ụzọ ịdị ọcha/nyocha | ≥99.0% (HPLC) |
pH | 5.0-8.0 |
Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
Ojiji | HIV-1 Protease Inhibitor Anti-HIV |
ngwugwu: Kalama, Aluminom foil bag, Cardboard Drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.
Atazanavir Sulfate (BMS-232632 Sulfate) (CAS: 229975-97-7) bụ nnu sulfate nke atazanavir nke bụ ihe mgbochi nje HIV-1 nke na-ahọrọ nke ọma, bụ onye na-egbochi protease mbụ kwadoro maka nchịkwa otu ugboro kwa ụbọchị.Atazanavir sulfate bụ mkpụrụ na onye na-egbochi CYP3A4, yana onye na-egbochi P-glycoprotein (P-gp).Atazanavir Sulfate bụkwa ihe mgbochi SARS-CoV 3CLpro nwere IC50 nke 3.49 μM.Atazanavir Sulfate bụ azapeptide na HIV-protease inhibitor nke a na-eji na ọgwụgwọ nke nje HIV na AIDS na-ejikọta ya na ndị ọzọ na-egbochi nje HIV, nke Bristol-Myers Squibb (BMS) mepụtara ma malite ya, n'okpuru ikike zuru ụwa ọnụ site na Novartis. maka ọgwụgwọ nje HIV.A malitere Atazanavir na US ka Reyataz ™ na Julaị 2003. Antiviral.Atazanavir egosila na ọ na-enwekarị ike karịa ihe mgbochi nje HIV-1 akwadoro ugbu a.Atazanavir na-ahọrọ nke ọma na-egbochi nhazi nje nke nje Gag na Gag-Pol polyproteins na nje nje HIV-1 site na ijikọta saịtị na-arụ ọrụ nke nje HIV-1, si otú a na-egbochi ịmepụta virions tozuru okè.Atazanavir anaghị arụ ọrụ megide nje HIV-2.