Betamethasone CAS 378-44-9 Ịdị Ọcha 97.0%~103.0% API Ihe Nrụpụta Dị Ọcha Dị Elu

Betamethasone CAS 378-44-9 Ịdị ọcha 97.0%~103.0% API Ụlọ ọrụ dị ọcha

Nkọwa dị mkpirikpi:

Aha Chemical: Betamethasone

Ọkụ: 378-44-9

Ọdịdị: White ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ White Crystalline ntụ ntụ

Ịdị ọcha: 97.0% ~ 103.0% nke C22H29FO5, na ntọala akpọnwụwo

API Ogo dị elu, mmepụta azụmahịa

Kpọtụrụ: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Nkọwa ngwaahịa

Ngwaahịa ndị emetụtara

Mkpado ngwaahịa

378-44-9 - Nkọwa:

Nbubata Azụmahịa Betamethasone nwere ịdị ọcha dị elu yana ịdị mma kwụsiri ike
Aha Chemical: Betamethasone
Ọkụ: 378-44-9

378-44-9 -Njirimara kemịkalụ:

Aha Chemical	Betamethasone
Ụdị okwu	Betamethasone isi;9alpha-Fluoro-16beta-Methylprednisolone;9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dion;(11beta,16alpha) -9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
Nọmba CAS	378-44-9
Ọnọdụ Ahịa	N'ọkwa, Mpụta Ihe ruru Tọn
Usoro ihe omimi	C22H29FO5
Ibu molekụla	392.47
Ebe Na-agbaze	235.0 ~ 237.0 ℃
Ọnọdụ mbupu	N'okpuru ọnọdụ okpomọkụ
COA & MSDS	Dị
Ụdị	Ruifu Chemical

378-44-9 -Nkọwapụta:

Ihe	Nkọwapụta
Ọdịdị	White ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha kristal ntụ ntụ
njirimara A	Infrared absorption
njirimara B	Nnwale njirimara Chromatographic dị obere
Ntụgharị ngwa anya akọwapụtara	+118.0° ruo +126.0° (Agbakọrọ na akpọnwụ akpọnwụ)
Ọdịghị ọcha nke Onwe Onye	≤1.00%
Mgbakọta adịghị ọcha	≤2.00%
Residual Solvents Methanol	≤3000ppm
Ihe ndị fọdụrụnụ chloroform	≤60ppm
Ọnwụ na ihicha	≤0.50% (Kọchaa ya na 105 ℃, awa 3)
Ihe fọdụrụ na mgbanye	≤0.20%
Ụzọ ịdị ọcha / nyocha	97.0% ~ 103.0% nke C22H29FO5 gbakọrọ na ntọala akpọnwụwo
Nlele ọkọlọtọ	Ndị China Pharmacopoeia (CP);EP10.0 na USP 42
Nkwakọ ngwaahịa na Nchekwa	Chekwaa n'ime akpa siri ike.Na-echekwa n'etiti 2 ℃ na 30 ℃.
Ngwa	Ngwakọta ọgwụ na-arụ ọrụ (API)

Ngwungwu & Nchekwa:

ngwugwu:Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Debe akpa ahụ nke ọma ma chekwaa n'ebe dị jụụ, kpọrọ nkụ (2 ~ 30 ℃) yana ụlọ nkwakọba ihe nke ọma na-adịghị na ihe ndị na-adabaghị adaba.Zere ọkụ siri ike na okpomọkụ, mmiri mmiri.
Mbupu:Jiri ikuku na-ebuga ụwa niile site na FedEx / DHL Express.Nye nnyefe ngwa ngwa na ntụkwasị obi.

Uru:

Ajụjụ:

378-44-9 - Ihe ize ndụ na nchekwa:

Koodu ihe egwu R40 - ihe akaebe nwere oke nke mmetụta carcinogenic
R48/20/21 -
R61 - nwere ike imerụ nwa e bu n'afọ
Nkọwa nchekwa S22 - Ekula uzuzu.
S36 - Yiri uwe nchebe kwesịrị ekwesị.
S45 - Ọ bụrụ na ihe mberede ma ọ bụ ọ bụrụ na ahụ adịghị gị mma, chọọ ndụmọdụ ahụike ozugbo (gosi akara ahụ mgbe ọ bụla enwere ike.)
S53 - Zere ikpughe - nweta ntuziaka pụrụ iche tupu ejiri ya.
WGK Germany 2
RTECS TU4000000
Koodu mpaghara:: 2937229000
Nsi LD50 ọnụ na òké:> 4500mg/kg

378-44-9 -Ngwa:

Betamethasone (CAS: 378-44-9), bụ nke adrenal corticosteroids, ọ bụ isomer nke dexamethasone, na ọrụ nke betamethasone yiri prednisolone na dexamethasone, o nwere mgbochi mkpali, mgbochi rheumatic, mgbochi-allergic na suppression. nke mgbochi ahụ na mmetụta ndị ọzọ na-emepụta ọgwụ, mmetụta mgbochi ya dị ike karịa dexamethasone, triamcinolone, hydrocortisone wdg, ọ nwere ike ibelata ma gbochie nzaghachi anụ ahụ na mbufụt ma wepụ okpomọkụ, ọbara ọbara na ọzịza kpatara site na mpaghara na-adịghị emerụ ahụ, si otú ahụ belata. arụmọrụ nke mbufụt, mgbochi mkpali mmetụta nke ngwaahịa a 0.3mg bụ hà dexamethasone 0.75mg, prednisone 5mg ma ọ bụ 25mg cortisone.Mmetụta njigide sodium Betamethasone bụ otu narị ugboro karịa hydrocortisone, na isi hypofunction adrenal, enwere ike iji ya na glucocorticoid maka ọgwụgwọ nnọchi, a na-ejikwa ya maka igbochi ma ọ bụ gbochie nzaghachi mgbochi nke cell, na-egbu oge mmeghachi omume nfụkasị na ibelata ihe mgbochi mbụ. mgbasawanye nzaghachi, a na-eji ya maka obere renin na obere ọrịa aldosterone na autonomic neuropathy na-akpata orthostatic hypotension.Ugbu a, a na-ejikwa betamethasone maka ọgwụgwọ ọrịa ogbu na nkwonkwo na-arụ ọrụ, ọrịa ogbu na nkwonkwo, lupus, ụkwara ume ọkụ siri ike, dermatitis siri ike, nnukwu leukemia, atopic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, na itching na ọgwụgwọ zuru oke nke ụfọdụ ọrịa.A na-egbochi ngwaahịa a na akụkọ ihe mere eme psychiatric siri ike, ọnya duodenal na-arụ ọrụ, anastomosis afọ na-adịbeghị anya, osteoporosis dị arọ, ọrịa shuga siri ike, ọbara mgbali elu, nje virus, nje bacteria, ọrịa fungal nke na-adabaghị na-achịkwa site na iji ọgwụ nje, thrombophlebitis, ọrịa anụ ahụ, dị otú ahụ. dị ka impetigo, tinea, jock itching na ndị ọzọ.

378-44-9 - USP35 Ọkọlọtọ:

Betamethasone
C22 H29FO5 392.46
Ime-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11,16) -.
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione [378-44-9].
Betamethasone nwere ihe na-erughị 97.0 pasent na ọ bụghị ihe karịrị 103.0 pasent nke C22H29FO5, gbakọọ na akpọnwụwo ndabere.
Nkwakọ ngwaahịa na nchekwa - Chekwaa n'ime akpa siri ike.Na-echekwa n'etiti 2 ℃ na 30 ℃.
Ụkpụrụ ntụaka USP <11>-
USP Betamethasone RS
njirimara-
A: Infrared absorption <197M>.
B: Nnwale njirimara Chromatographic nke dị obere <201>-
Ngwọta nnwale- Kwadebe ihe ngwọta nke Betamethasone na mmanya kpọrọ nkụ nwere 0.5 mg kwa ml.
Na-emepe usoro ihe mgbaze: ngwakọta nke chloroform na diethylamine (2: 1).
Usoro-Gaa n'ihu dị ka a gwara ya n'isiakwụkwọ ahụ, ewezuga ịchọta ebe ndị ahụ site n'ịfesa sulfuric acid dị nro (1 n'ime 2) na ikpo ọkụ na efere ọkụ ma ọ bụ n'okpuru oriọna ruo mgbe ntụpọ pụtara.
Ntugharị akọwapụtara nke ọma <781S>: n'etiti +118 na +126, gbakọọ na ntọala akpọnwụwo.
Ngwọta ule: 5 mg kwa ml, na methanol.
Ọnwụ na ihicha 731-Kọchaa ya na 105 maka awa 3: ọ na-efunahụ ihe karịrị 1.0% nke ibu ya.
Ihe fọdụrụ na mgbanye 281: ọ bụghị karịa 0.2%, a na-eji platinum crucible mee ihe.
adịghị ọcha nkịtị 466-
Ngwọta ule: methanol.
Standard ngwọta: methanol.
Olu ngwa: 10µL.
Eluant: ngwakọta nke toluene, acetone, methyl ethyl ketone, na formic acid (55:20:20:5), n'ime ụlọ na-enweghị ihe ọ bụla.
Ọhụụ: 5.
Nyocha -
Usoro mkpanaaka - Kwadebe ngwakọta mmiri na acetonitrile akọrọ na nke gbazere (63:37).Mee mgbanwe ọ bụrụ na ọ dị mkpa (lee Dabara Sistemu n'okpuru Chromatography 621).
Ihe ngwọta dị n'ime - Kwadebe ngwọta nke propylparaben na mmanya na-aba n'anya na-enwe mkpokọta amara nke ihe dịka 0.25 mg kwa ml.
Nkwadebe ọkọlọtọ-Kwụsa ọnụ ọgụgụ USP Betamethasone RS a tụrụ n'ụzọ ziri ezi n'ime mmanya iji nweta ngwọta nwere njiri mara nke ihe dịka 0.2 mg kwa ml.Nyefee 10.0 ml nke ihe ngwọta a na vial kwesịrị ekwesị, ma gbakwunye 10.0 ml nke ngwọta dị n'ime, iji nweta nkwadebe ọkọlọtọ ebe a maara ihe dị ka 0.1 mg nke betamethasone na ihe dịka 0.125 mg nke propylparaben kwa ml.
Nkwadebe nyocha- Iji ihe dị ka 80 mg nke Betamethasone, a tụrụ ya nke ọma, kwadebe dị ka akwadoro maka nkwadebe ọkọlọtọ.
Sistemụ Chromatographic (lee Chromatography 621) -Kromatograph mmiri mmiri nwere ihe nchọta 240-nm yana kọlụm 4.6mm × 25-cm nke nwere nkwakọba L1.Onu ogugu a bu ihe dika 1.0 ml kwa nkeji.Chromatograph the Standard nkwadebe, na dekọọ nzaghachi kacha elu dị ka a na-eduzi maka Usoro: oge njide ikwu ihe dị ka 1.0 maka betamethasone na 1.4 maka propylparaben;mkpebi, R, n'etiti betamethasone na propylparaben abụghị ihe na-erughị 3.0;na ndị ikwu ọkọlọtọ ndiiche maka oyiri injections abụghị ihe karịrị 2.0%.
Usoro-iche iche nha nha nha (ihe dị ka 10 µL) nke nkwadebe ọkọlọtọ na nkwadebe Assay n'ime chromatograph, dekọọ chromatogram, wee tụọ azịza maka ọnụ ọgụgụ ndị bụ isi.Gbakọọ ọnụọgụ, na mg, nke C22H29FO5 n'ime akụkụ nke Betamethasone nke usoro a were were:
800C (RU / RS)
nke C bụ ntinye uche, na mg kwa ml, nke USP Betamethasone RS na nkwadebe Standard;na RU na RS bụ ọnụ ọgụgụ kachasị elu nke ọnụ ọgụgụ betamethasone yana ụkpụrụ dị n'ime nke enwetara site na nkwadebe Assay na nkwado ọkọlọtọ, n'otu n'otu.