Bortezomib CAS 179324-69-7 Ịdị Ọcha ≥99.0% (HPLC) API Ụlọ Ọrụ Dị Ọcha Dị Elu
Nyefee Bortezomib njikọ etiti nwere ịdị ọcha dị elu
(1S,2S,3R,5S)-(+)-2,3-Pinadiol CAS 18680-27-8
(1R,2R,3S,5R)-(-)-2,3-Pinanediol CAS 22422-34-0
Bortezomib CAS 179324-69-7
| Aha Chemical | Bortezomib |
| Ụdị okwu | Velcade, MG-341, PS-341 |
| Nọmba CAS | 179324-69-7 |
| Nọmba CAT | RF-API65 |
| Ọnọdụ Ahịa | Na Akụrụngwa, Mpụta Ihe ruru narị narị kilograms |
| Usoro ihe omimi | C19H25BN4O4 |
| Ibu molekụla | 384.24 |
| Ebe Na-agbaze | 122.0 ~ 124.0 ℃ |
| Njupụta | 1.214 |
| Ntụgharị uche | 1.564 |
| Solubility | Soluble na Chloroform, DMSO, ethanol na methanol |
| Nkwụsi ike | Hygroscopic na iru mmiri nwere mmetụta |
| Ọnọdụ mbupu | Ebugara n'okpuru okpomọkụ gburugburu |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta |
| Ọdịdị | Ọcha ma ọ bụ Gbanyụọ-Ọcha ntụ ntụ |
| Ụzọ ịdị ọcha / nyocha | ≥99.0% (HPLC) |
| Ọnwụ na ihicha | ≤0.50% |
| Ihe fọdụrụ na mgbanye | ≤0.20% |
| Ntụgharị anya | -41.0° ~ -46.0° |
| Ọla dị arọ | ≤20ppm |
| Acidity | 4.0-7.0 |
| Isomer | ≤0.50% |
| Otu adịghị ọcha | ≤0.50% |
| Mgbakọta adịghị ọcha | ≤1.0% |
| Ihe mgbaze fọdụrụnụ | |
| Methanol | ≤0.30% |
| Dichloromethane | ≤0.05% |
| Hexane | ≤0.02% |
| Ethyl acetate | ≤0.50% |
| Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
| Ojiji | API |
ngwugwu: Kalama, Aluminom foil bag, Cardboard Drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.
Shanghai Ruifu Chemical Co., Ltd bụ onye na-emepụta ihe na onye na-ebubata Bortezomib (CAS: 179324-69-7) nwere àgwà dị elu, API.
Bortezomib, nke a na-ere n'okpuru aha aha Velcade n'etiti ndị ọzọ, bụ ọgwụ mgbochi ọrịa cancer nke a na-eji agwọ ọtụtụ myeloma na lymphoma mantle cell.A kwadoro Bortezomib maka ọgwụgwọ ahụike na United States na 2003 yana na European Union na 2004. Ọ dị na Ndepụta Ọgwụ Ndị Dị Mkpa nke Òtù Ahụ Ike Ụwa.Bortezomib bụ onye na-egbochi proteasome nke mbụ ka a kwadoro na US FDA maka otutu myeloma, ọrịa kansa ọbara.Onye na-emechi ihe na-emegharị emegharị nke 26S proteasome-otu akụkụ multiprotein nwere ụdị gbọmgbọm achọtara na nucleus na cytosol nke sel eukaryotic niile.Bortezomib bụ onye na - egbochi proteasome 26S nke na - ahọrọ ma sie ike, nke bụ ihe mgbapụta boronic acid dipeptide.Ọmụmụ mkpụrụ ndụ cancer nke mmadụ na-egosi Bortezomib iji gbochie PKR-dị ka endoplasmic reticulum (ER) kinase ma kwalite nrụgide ER, na-eduga na apoptosis.
