Candesartan Cilexetil CAS 145040-37-5 Ịdị Ọcha> 99.0% (HPLC) API Foto egosipụtara

Candesartan Cilexetil CAS 145040-37-5 Ịdị Ọcha> 99.0% (HPLC) Ụlọ ọrụ API

Nkọwa dị mkpirikpi:

Aha Chemical: Candesartan Cilexetil

CAS: 145040-37-5

Dị ọcha:> 99.0% (HPLC)

Ọdịdị: White ka Gbanyụọ-White Crystalline ntụ ntụ

Onye na-anabata Angiotensin II ahọpụtara

API Ogo dị elu, mmepụta azụmahịa

E-Mail: alvin@ruifuchem.com

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Ngwaahịa ndị emetụtara

Mkpado ngwaahịa

Nkọwa:

Ruifu Chemical Supply Candesartan Cilexetil Intermediate na ịdị ọcha dị elu
Candesartan Cilexetil CAS 145040-37-5
Candesartan CAS 139481-59-7
1-Chloroethyl Cyclohexyl Carbonate CAS 99464-83-2
Candesartan Cilexetil Intermediate Eethyl Ester C6 CAS 139481-41-7
Candesartan Cilexetil Intermediate CAS 139481-44-0
Tril Candesartan Cilexetil CAS 170791-09-0

Njirimara kemịkalụ:

Aha Chemical	Candesartan Cilexetil
Ụdị okwu	TCV-116;1- (((Cyclohexyloxy) carbonyl) oxy) ethyl 1- (2'- (1H-tetrazol-5-yl)-[1,1'-biphenyl] -4-yl) methyl) -2-ethoxy-1H -benzo[d] imidazole-7-carboxylate
Nọmba CAS	145040-37-5
Nọmba CAT	RF-PI1891
Ọnọdụ Ahịa	N'ọkwa, Mpụta Ihe ruru Tọn
Usoro ihe omimi	C33H34N6O6
Ibu molekụla	610.66
Ụdị	Ruifu Chemical

Nkọwapụta:

Ihe	Nkọwapụta
Ọdịdị	Ntụ ntụ kristal na-acha ọcha ruo na-agbanyụọ
njirimara HPLC	Oge njide nke isi kacha elu na chromatogram nke ihe nlele kwekọrọ na nke chromatogram nwetara na ọkọlọtọ.
njirimara IR	IR infrared absorption spectrum bụ otu nke ọkọlọtọ Candesartan Cilexetil.
Ngwọta doo anya na agba	Ngwọta na chloroform na 5% doro anya na enweghị agba
Ụzọ ịdị ọcha / nyocha	> 99.0% (HPLC)
Ebe Na-agbaze	155.0 ~ 160.0 ℃
Ọnwụ na ihicha	<0.30%
Ihe fọdụrụ na mgbanye	<0.10%
Ọla dị arọ	<10ppm
Arsenic (dị ka)	<1pm
Nkesa nha urughuru	90% <30 μm
Ihe adịghị ọcha	nke HPLC
Ethyl Candesartan	<0.15%
Desethyl Candesartan	<0.15%
N2-Ethyl Candesartan Cilexei	<0.15%
Ọdịghị ọcha ọ bụla amabeghị	<0.15%
Mgbakọta adịghị ọcha	<0.60%
Nyocha site na Potentiometry	99.0 ~ 101.0% nke C33H34N6O6, gbakọọ na ihe anhydrous
Organic Volatile adịghị ọcha
Methano	<0.30%
Ethanol	<0.50%
Diethyl Ether	<0.50%
Aceton	<0.50%
Dichloromethan	<0.06%
Dimethylformamide	<0.088%
Ngwakọta microbiological
Ngụkọta ọnụ ọgụgụ microbial nke ikuku ikuku	<1000cfu/g
Ebu & Yist	<100cfu/g
E.Coli	Adịghị
Salmonella	Adịghị
Nlele ọkọlọtọ	Standardkpụrụ ụlọ ọrụ
Ojiji	API;Ihe nnọchi anya antihypertensive

Ngwungwu & Nchekwa:

ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ

Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri

Uru:

Ajụjụ:

Ngwa:

Candesartan Cilexetil (TCV-116) (CAS: 145040-37-5) bụ angiotensin II nnabata antagonist na IC50 nke 0.26 nM, eji na ọgwụgwọ nke ọbara mgbali elu.Candesartan bụ ihe mgbochi angiotensin-receptor blocker (ARB) nke enwere ike iji naanị ya ma ọ bụ ndị ọrụ ndị ọzọ na-agwọ ọbara mgbali elu.A na-enye ya ọnụ dị ka prodrug, candesartan cilexetil, nke na-agbanwe ngwa ngwa na metabolite na-arụ ọrụ, candesartan, n'oge nnabata na tract gastrointestinal.Candesartan na-ebelata ọbara mgbali site na imegide usoro renin-angiotensin-aldosterone (RAAS);ọ na-asọ mpi angiotensin II maka ijikọ na ụdị-1 angiotensin II nnabata (AT1) subtype ma na-egbochi mmetụta ọbara mgbali elu nke angiotensin II.N'adịghị ka angiotensin-converting enzyme (ACE) inhibitors, ARB enweghị mmetụta ọjọọ nke ụkwara akọrọ.Enwere ike iji Candesartan na-agwọ ọbara mgbali elu, ọbara mgbali elu systolic dịpụrụ adịpụ, hypertrophy ventricular aka ekpe na ọrịa shuga nephropathy.Enwere ike iji ya dị ka onye nnọchi anya ọzọ maka ọgwụgwọ nkụda obi, arụrụ arụ systolic, infarction myocardial na ọrịa akwara obi.