Capecitabine CAS 154361-50-9 Ịdị Ọcha 98.0% ~ 102.0% API Ogo dị elu
Mgbakwunye Capecitabine metụtara azụmahịa:
5-Fluorocytosine CAS: 2022-85-7
2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine CAS: 161599-46-8
1,2,3-Tri-O-acetyl-5-deoxy-β-D-ribofuranose CAS: 62211-93-2
Capecitabine CAS: 154361-50-9
| Aha Chemical | Capecitabine |
| Nọmba CAS | 154361-50-9 |
| Nọmba CAT | RF-API08 |
| Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
| Usoro ihe omimi | C15H22FN3O6 |
| Ibu molekụla | 359.35 |
| Ebe Na-agbaze | 110.0 ~ 121.0 ℃ |
| Ọnọdụ mbupu | N'okpuru ọnọdụ okpomọkụ |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta |
| Ọdịdị | Ọcha ntụ ntụ |
| njirimara | Ihe nlele IR Spectrum kwesịrị ikwekọ na ụdịdị dị iche iche nke ọkọlọtọ ntụaka |
| njirimara | HPLC: Oge njide nke isi ihe nrịba ama kwesịrị dabara na nke ọkọlọtọ ntụaka. |
| Ịdị ọcha | 98.0% ~ 102.0% (na anhydrous na ihe mgbaze-free ndabere) |
| Ntụgharị anya | +96.0°~+100° |
| Mmiri (KF) | ≤0.30% |
| Ihe fọdụrụ na mgbanye | ≤0.10% |
| Ọla dị arọ | ≤20ppm |
| Njikọta adịghị ọcha A | ≤0.30% |
| Njikọta adịghị ọcha B | ≤0.30% |
| Njikọta adịghị ọcha C | ≤0.10% (2',3'-Di O-Acety-5'-deoxy-5-Fluoroytidine) |
| Otu adịghị ọcha akọwapụtaghị | ≤0.10% |
| Mgbakọta adịghị ọcha akọwapụtaghị | ≤0.50% |
| Mgbakọta adịghị ọcha | ≤1.5% |
| Ihe mgbaze fọdụrụnụ (GC) | |
| Methanol | ≤3000ppm |
| Ethanol | ≤5000ppm |
| Dichloromethane | ≤600ppm |
| Ethyl acetate | ≤5000ppm |
| Toluene | ≤800ppm |
| Pyridine | ≤200ppm |
| Hexane | ≤290ppm |
| Ngụkọta ọnụ ọgụgụ microbial nke ikuku ikuku | ≤200cfc/g |
| Yist na Akpụkpọ Agụ | ≤50cfc/g |
| Nlele ọkọlọtọ | United States Pharmacopoeia (USP) |
| Ojiji | Ọrịa ara Metastatic |
ngwugwu: Kalama, Aluminom foil bag, kaadiboodu drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.
Capecitabine (CAS: 154361-50-9) bụ ụdị ọhụrụ nke ọgwụ pyrimidine nwere fluorinated.Roche Pharmaceuticals mepụtara Capecitabine, aha azụmahịa ya bụ Xeloda.Capecitabine nwere ike gbanwee na vivo n'ime 5-FU, ọgwụ anti-metabolizim fluorine pyrimidine deoxynucleoside carbamate ọgwụ nke na-elekwasị anya na mkpụrụ ndụ kansa iji gbochie nkewa sel ma mebie RNA na njikọ protein.A na-ejikọta mmetụta ya na ọkwa nke TP enzyme okwu na anụ ahụ neoplastic na DPD enzyme na vivo okwu.Ọ dabara nke ọma dị ka ọgwụgwọ ọzọ maka ndị ọrịa kansa ara nke mbụ ma ọ bụ metastatic bụ ndị na-anabataghị ọgwụ nje paclitaxel ma ọ bụ anthracycline.Dị ka ọgwụ mgbochi ọrịa cancer, a na-ejikarị agwọ ọrịa kansa ara ma ọ bụ metastatic dị elu, yana ọgwụgwọ maka ọrịa cancer akpa ume na-abụghị obere cell, cancer pancreatic, cancer eriri afo, cancer rectal, colon cancer, gastric cancer, na ndị ọzọ siri ike etuto ahụ. .
