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Carvedilol CAS 72956-09-03 Ịdị Ọcha>99.0% (HPLC) Foto egosipụtara
  • Carvedilol CAS 72956-09-03 Ịdị ọcha> 99.0% (HPLC)

Carvedilol CAS 72956-09-03 Ịdị ọcha> 99.0% (HPLC)

Nkọwa dị mkpirikpi:

Aha Chemical: Carvedilol

Nọmba: 72956-09-03

Dị ọcha:> 99.0% (HPLC)

Ọdịdị: White Crystalline ntụ ntụ

Kpọtụrụ: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


Nkọwa ngwaahịa

Ngwaahịa ndị emetụtara

Mkpado ngwaahịa

Nkọwa:

Shanghai Ruifu Chemical Co., Ltd bụ onye na-emepụta Carvedilol (CAS: 72956-09-03) nwere oke mma.Ruifu Chemical nwere ike ịnye nnyefe zuru ụwa ọnụ, ọnụahịa asọmpi, ọrụ magburu onwe ya, obere na nnukwu ọnụọgụ dị.Ịzụta Carvedilol,Please contact: alvin@ruifuchem.com

Ndị etiti emetụtara:

Njikọ njikọ nke Carvedilol

Njirimara kemịkalụ:

Aha Chemical Carvedilol
Ụdị okwu 1- (9H-Carbazol-4-yloxy) -3-[2- (2-Methoxyphenoxy) ethyl] amino] -2-Propanol;Onye omenkà;Cadilan;Carca;Kadivas;Carloc;Carvas;Carvedilol;Carvediol;Coreg;DQ 2466;Dilatrend;Dimitone;Eucardic;Korvasan;Kredex;Querto;Talliton;BM-14190
Ọnọdụ Ahịa Na ngwaahịa, GMP Commercial
Nọmba CAS 72956-09-3
Usoro ihe omimi C24H26N2O4
Ibu molekụla 406.48 g/mol
Ebe Na-agbaze 115.0 ruo 119.0 ℃
Njupụta 1.250±0.06 g/cm3
Solubility na Mmiri Na-adịghị edozi n'ime mmiri
Solubility Soluble na methanol.Obere Soluble na Ethanol, Ether
Okpomọkụ nchekwa. Ebe dị jụụ na nkụ (2 ~ 8 ℃)
COA & MSDS Dị
Ụdị Ruifu Chemical

Nkọwapụta:

Ihe Ụkpụrụ nyocha Nsonaazụ
Ọdịdị White Crystalline ntụ ntụ Na-akwado
Ọnwụ na ihicha ≤0.50% (105 ℃ maka awa 3) 0.25%
Ihe fọdụrụ na mgbanye ≤0.10% 0.07%
Ihe ndị emetụtara    
Mgbakọta adịghị ọcha ≤0.50% Na-akwado
adịghị ọcha A ≤0.20% Na-akwado
adịghị ọcha C ≤0.02% Na-akwado
Ọdịghị ọcha nke Onye Ọ bụla ọzọ ≤0.10% Na-akwado
Ọla dị arọ (Pb) ≤10ppm <10ppm
Ụzọ ịdị ọcha / nyocha > 99.0% (HPLC) 99.72%
Spectrum infrared Dabara na Ọdịdị Na-akwado
Mmechi A nwalela ngwaahịa a wee kwado nkọwapụta

Ngwugwu/Nkwakọba/Mbupu:

ngwugwu:Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Chekwaa n'ime akpa mechiri emechi.Chekwaa n'ebe dị jụụ, kpọrọ nkụ (2 ~ 8 ℃) yana ụlọ nkwakọba ihe ikuku na-ekupụ nke ọma pụọ ​​na ihe ndị na-ekwekọghị ekwekọ.Chebe site na ìhè na mmiri mmiri.
Mbupu:Jiri ikuku na-ebuga ụwa niile site na FedEx / DHL Express.Nye nnyefe ngwa ngwa na ntụkwasị obi.

Uru:

Ike zuru oke: akụrụngwa na ndị ọrụ nka zuru oke

Ọrụ Ọkachamara: Otu nkwụsị ịzụrụ ọrụ

Ihe ngwugwu OEM: ngwugwu omenala na akara dị

Nnyefe ngwa ngwa: Ọ bụrụ n'ime ngwaahịa, ekwenyere nnyefe ụbọchị atọ

Nkwanye kwụsiri ike: Jikwaa ngwaahịa ezi uche dị na ya

Nkwado nka na ụzụ: Ngwọta teknụzụ dị

Ọrụ Synthesis Custom: sitere na gram ruo kilos

Ogo dị elu: guzobe usoro mmesi obi ike zuru oke

Ajụjụ:

Kedu ka esi azụta?Biko kpọtụrụDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

Ahụmịhe afọ 15?Anyị nwere ihe karịrị 15 afọ nke ahụmahụ na mmepụta na mbupụ nke a dịgasị iche iche nke elu mma pharmaceutical intermediates ma ọ bụ ezi kemịkal.

Isi ahịa?Na-ere ahịa ụlọ, North America, Europe, India, Korea, Japanese, Australia, wdg.

Uru?Ogo kachasị elu, ọnụ ahịa dị ọnụ ala, ọrụ ọkachamara na nkwado teknụzụ, nnyefe ngwa ngwa.

OgoNkwenye?Usoro njikwa mma siri ike.Ngwá ọrụ ọkachamara maka nyocha gụnyere NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, wdg.

Ihe atụ?Ọtụtụ ngwaahịa na-enye ihe nlele efu maka nyocha dị mma, ndị ahịa kwesịrị ịkwụ ụgwọ mbupu.

Nyocha ụlọ ọrụ?Nnabata nyocha ụlọ ọrụ.Biko mee oge oge tupu oge eruo.

MOQ?Enweghị MOQ.A na-anabata obere usoro.

Oge Mbuga ozi? Ọ bụrụ n'ime ngwaahịa, ekwenyere nnyefe ụbọchị atọ.

Ụgbọ njem?Site Express (FedEx, DHL), nke ikuku, site n'oké osimiri.

Akwụkwọ?Mgbe ọrụ ahịa gasịrị: COA, MOA, ROS, MSDS, wdg nwere ike ịnye.

Synthesis omenala?Nwere ike ịnye ọrụ nhazi ahaziri iche ka ọ dabara mkpa nyocha gị nke ọma.

Usoro ịkwụ ụgwọ?A ga-ebu ụzọ ziga akwụkwọ ọnụahịa Proforma mgbe nkwenye nke iwu, kpuchiri ozi ụlọ akụ anyị.Ịkwụ ụgwọ site na T/T (Telex Nyefee), PayPal, Western Union, wdg.

72956-09-3 - Ozi nchekwa:

Koodu egwu N,Xn
Nkwupụta ihe egwu 51/53-36/37/38-20/21/22
Nkwupụta nchekwa 61-36-26
RIDADR UN 3077 9/PG 3
WGK Germany 3
RTECS UA8670000
HazardKlas IRITANT
PackingGroup III
Data ihe dị ize ndụ 72956-09-3(Data ihe dị ize ndụ)
Nsi LD50 ọnụ na nkịta:> 1gm/kg

72956-09-3 -Ngwa:

Carvedilol (CAS: 72956-09-03) bụ vasodilating beta-blocker bara uru na ọgwụgwọ ọbara mgbali elu na angina pectoris.Na mgbakwunye na iwetulata ọbara mgbali elu, carvedilol na-ebelata mkpokọta nguzogide vaskụla na-enweghị tachycardia reflex na-emekarị na vasodilators.A na-akọ na a na-anabata ya nke ọma site na mmetụta na-egbochi akụrụ.

Ebubere Carvedilol na Belgium na 1985. Ngwaahịa a nwere ike igbochi alfa na ndị na-anabata beta, ọ nweghị ọrụ dị n'ime, na oke ejiji na calcium antagonism.Ọ nwere mmetụta siri ike nke igbochi ndị na-anabata beta, nke nwere ike ịgbasa arịa ọbara, belata nguzogide mpụta na mbelata ọbara mgbali, ma nwee mmetụta dị nta na mmepụta obi na ọnụọgụ obi.Enwere ike iji Clinical maka ọbara mgbali elu na angina pectoris.

72956-09-3 - USP 35 Ọkọlọtọ:

Nkọwa
Carvedilol nwere NLT 98.0% na NMT 102.0% nke C24H26N2O4, gbakọọ na ntọala akpọnwụwo.
Nchọpụta
• A. Infrared Absorption <197K>
• B. Oge njide nke isi ọnụ ọgụgụ kachasị elu nke ngwọta Sample dabara na nke Standard Solution, dị ka enwetara na Assay.
ASSAY
• Usoro
Nchekwa: 2.72 g/L nke monobasic potassium phosphate.Gbanwee na itughari phosphoric acid ka ọ bụrụ pH nke 2.0.
Usoro mkpanaka: Acetonitrile na ihe nchekwa (31:69)

Ngwọta kwesịrị ekwesị nke sistemu: 0.05 mg/mL nke ọ bụla nke USP Carvedilol RS na USP Carvedilol metụtara Compound A RS na usoro mkpanaka.
Ngwọta ọkọlọtọ: 0.04 mg/mL nke USP Carvedilol RS na usoro mkpanaka
Ngwọta nlele: 0.04 mg/mL nke Carvedilol na usoro mkpanaka
Sistemụ chromatographic

(Lee Chromatography <621>, Kwesịrị ekwesị Sistemu.)
Ụdị: LC
Ihe nchọpụta: UV 240 nm
Ogidi: 4.6-mm × 15-cm;5-µm nkwakọ ngwaahịa L7
Okpomọkụ kọlụm: 55 ℃
Ọnụego mmiri: 1 ml / min
Oge ịgba ọsọ: 60 min
Nha igba ogwu: 10µL
Sistemu kwesịrị ekwesị

Ọmụma: Ngwọta dabara adaba sistemụ
Kwesịrị ekwesị chọrọ

Mkpebi: NLT 4.0 n'etiti carvedilol na carvedilol metụtara ogige A
Ihe na-akụ ọdụ: NMT 1.5 maka ọnụ ọgụgụ carvedilol
Ngbanwe ọkọlọtọ emetụtara: NMT 2%
Nyocha

Ihe atụ: Ngwọta ọkọlọtọ na ngwọta nlele
Gbakọọ pasentị carvedilol (C24H26N2O4) n'akụkụ nlele emere:
Nsonaazụ = (rU/rS) × (CS/CU) × 100
rU= nzaghachi kacha elu nke carvedilol sitere na ngwọta Sample
rS= nzaghachi kacha elu nke carvedilol sitere na ngwọta Standard
CS = ntinye nke carvedilol na ngwọta Standard (mg / ml)
CU = Ntinye uche nke Carvedilol na ngwọta nlele (mg / ml)
Usoro nnabata: 98.0% -102.0% na ntọala akpọnwụwo
IHE adịghị ọcha
• Ihe fọdụrụ na mgbanye <281>: NMT 0.1% sitere na 1 g
• Ọla dị arọ, Usoro II <231>: NMT 10 ppm
• Organic Impurities, Usoro 1: [Rịba ama-Na ndabere nke adịghị dị ugbu a, rụọ ma Organic adịghị ọcha, Usoro 1 ma ọ bụ Organic adịghị ọcha, Usoro 2. Organic adịghị ọcha, Usoro 2 na-atụ aro mgbe carvedilol metụtara compound F bụ ike adịghị ọcha.]

Usoro nchekwa na mkpanaka: Kwadebe dị ka a gwara ya na Assay.
Usoro dabara adaba: 0.05 mg / mL nke ọ bụla nke USP Carvedilol RS na USP Carvedilol metụtara Compound C RS na usoro mkpanaka.
Ngwọta ọkọlọtọ: 1 µg/mL nke ọ bụla nke USP Carvedilol RS, USP Carvedilol Related Compound A RS, USP Carvedilol Related Compound B RS, USP Carvedilol Related Compound D RS, na USP Carvedilol Njikọ Njikọ E RS, na 0.2 µg/mL nke USP Carvedil. Ngwakọta C RS metụtara na usoro mkpanaka
Ngwọta nlele: 1 mg / ml nke Carvedilol na usoro mkpanaka
Sistemụ chromatographic
(Lee Chromatography <621>, Kwesịrị ekwesị Sistemu.)
Ụdị: LC

Ihe nchọpụta: Ogologo wavele nke abụọ, UV 220 na 240 nm.Jiri 220 nm maka quantitating carvedilol metụtara compound E, ma jiri 240 nm maka carvedilol na ndị ọzọ niile metụtara ogige.
Ogidi: 4.6-mm × 15-cm;5-µm nkwakọ ngwaahịa L7
Okpomọkụ kọlụm: 55 ℃
Ọnụego mmiri: 1 ml / min
Nha igba ogwu: 20µL
Sistemu kwesịrị ekwesị

Ọmụma: Ngwọta dabara adaba sistemụ
Kwesịrị ekwesị chọrọ

Mkpebi: NLT 17 n'etiti carvedilol na carvedilol metụtara ogige C
Nyocha
Ihe atụ: Ngwọta ọkọlọtọ na ngwọta nlele
Gbakọọ pasent nke ihe jikọrọ carvedilol A, carvedilol metụtara compound B, carvedilol metụtara C, carvedilol metụtara compound D, carvedilol metụtara compound E, na adịghị ọcha ọ bụla nke onye ọ bụla n'ime akụkụ nke Carvedilol were:
Nsonaazụ = (rU/rS) × (CS/CU) × 100
rU = nzaghachi kacha elu nke ngwakọta yiri ya ma ọ bụ adịghị ọcha ọ bụla sitere na ngwọta Sample
rS = nzaghachi kacha elu nke ngwakọta metụtara ya kwekọrọ na ngwọta Standard.Iji gbakọọ pasent nke adịghị ọcha ọ bụla ọzọ, jiri nzaghachi kacha elu nke carvedilol.
CS = ntinye aka nke ihe jikọrọ ya na ngwọta Standard (mg/mL).Iji gbakọọ pasent nke adịghị ọcha ọ bụla maka CS, jiri ntinye uche nke USP Carvedilol RS.
CU = Ntinye uche nke Carvedilol na ngwọta nlele (mg / ml)
Usoro nnabata: Lee Tebụl 1.

Tebụl 1
Aha Oge Njide Oyiyi Usoro nnabata, NMT (%)
Ihe metụtara Carvedilol Ea 0.35 0.1
Ihe metụtara Carvedilol Ab 0.52 0.1
Carvedilol bisalkylpyrocatechol ewepụtara (ọ bụrụ na ọ dị)c 0.70 0.15
Carvedilol 1.0 -
Ihe metụtara Carvedilol Cd 3.6 0.02
Ihe metụtara Carvedilol De 5.0 0.1
Ihe metụtara Carvedilol Bf 8.5 0.1
Ihe ọ bụla ọzọ adịghị ọcha n'otu n'otu - 0.10
Mgbakọta adịghị ọcha - 0.5g
2- (2-Methoxyphenoxy) ethyl amine.
b 1- (4- (2-Hydroxy-3- (2- (2-methoxyphenoxy) ethylamino) propoxy) -9H-carbazol-9-yl) -3- (2- (2-methoxyphenoxy) ethylamino) propan-2 -ọl.
c 3,3¢-{2,2¢-[1,2-Phenylenebis(oxy)]bis(ethane-2,1-diyl)}bis(azanediyl)bis(1-(9H-carbazol-4-yloxy) propan-2-ol).
d 1- (9H-Carbazol-4-yloxy) -3- (benzyl (2- (2-methoxyphenoxy) ethyl) amino) propan-2-ol.
e 4-(Oxiran-2-ylmethoxy) -9H-carbazole.
f 3,3¢ (2- (2-Methoxyphenoxy) ethylazanediyl)bis (1- (9H-carbazol-4-yloxy) propan-2-ol).
g Leghara adịghị ọcha ọ bụla na-erughị 0.01%.
• Organic adịghị ọcha, Usoro 2

Ngwọta A: Acetonitrile na trifluoroacetic acid (100: 0.1)
Ngwọta B: Trifluoroacetic acid na mmiri (0.1: 100)
Ihe mgbaze: acetonitrile, trifluoroacetic acid, na mmiri (22: 0.1: 78)
Usoro mkpanaka: Lee Tebụl 2
Tebụl 2
Oge
(Nkeji)		 Ngwọta A
(%)		 Ngwọta B
(%)
0 22 78
20 22 78
33 38 62
45 38 62
55 55 45
65 55 45
68 22 78
80 22 78
Ngwọta kwesịrị ekwesị sistemu: 1.0 mg/mL nke USP Carvedilol System Suitability Mixture RS in Diluent
Ihe ngwọta nlele: 1 mg / ml nke Carvedilol na diluent
Sistemụ chromatographic
(Lee Chromatography <621>, Kwesịrị ekwesị Sistemu.)
Ụdị: LC
Ihe nchọpụta: UV 240 nm
Ogidi: 4.6-mm x 15-cm;5-µm nkwakọ ngwaahịa L68
Okpomọkụ kọlụm: 30 ℃
Ọnụego mmiri: 1.4ml/min
Nha igba ogwu: 20µL
Sistemu kwesịrị ekwesị
Ọmụma: Ngwọta dabara adaba sistemụ
Kwesịrị ekwesị chọrọ
Mkpebi: NLT 1.8 n'etiti carvedilol na carvedilol metụtara ogige F
Nyocha
Ihe atụ: Ngwọta nlele
Gbakọọ pasent nke adịghị ọcha ọ bụla na akụkụ Carvedilol were:
Nsonaazụ = (rU/rT) × 100
rU = nzaghachi kacha elu maka adịghị ọcha ọ bụla na ngwọta Sample
rT = nchikota nzaghachi kacha elu na ngwọta Sample
Usoro nnabata: Lee Tebụl 3.
Tebụl 3

Aha ikwu
Njide
Oge		 Nnabata
Usoro,
NMT (%)
Ihe metụtara Carvedilol Aa 0.7 0.1
Carvedilol 1.0 -
Ihe metụtara Carvedilol Fb 1.2 0.1c
N-Isopropylcarvedilold 1.6 0.1
Ihe metụtara Carvedilol Ce 1.8 0.02
Ihe metụtara Carvedilol Bf 2.1 0.1
Biscarbazoleg 3 0.1
Ihe ọ bụla ọzọ adịghị ọcha n'otu n'otu - 0.1
Mgbakọta adịghị ọcha - 0.5
a 1- (4- (2-Hydroxy-3- (2- (2-methoxyphenoxy) ethylamino) propoxy) -9Hcarbazol-9-yl) -3- (2- (2-methoxyphenoxy) ethylamino) propan-2-ol. .
b 1- (2- (2-Methoxyphenoxy) ethylamino) -3- (6,7,8,9-tetrahydro-5H-carbazol-4-yloxy) propan-2-ol.
c A na-agụta adịghị ọcha a site na iji usoro n'okpuru Organic adịghị ọcha, Usoro 3: Carvedilol Related Compound F.
d 1- (H-Carbazol-4-yloxy) -3-[2- (2-methoxyphenoxy) ethyl] N-isopropylamino] -2-propanol.
e 1- (9H-Carbazol-4-yloxy) -3- (benzyl (2- (2-methoxyphenoxy) ethyl) amino) propan-2-ol.
f 3,3'-(2- (2-Methoxyphenoxy) ethylazanediyl)bis (1- (9H-carbazol-4-yloxy) propan-2-ol).
g 1,3-Bis-(9H-carbazol-4-yloxy) -2-propanol.
• Ihe ndị na-adịghị ọcha, Usoro 3: Ngwakọta metụtara Carvedilol F (ọ bụrụ na ọ dị)

Ngwọta A: Trifluoroacetic acid na mmiri (0.5:100)
Ngwọta B: methanol na trifluoroacetic acid (100: 0.5)
Ihe mgbaze: mmiri na acetonitrile (1: 1)
Usoro mkpanaaka: Ngwọta A na Ngwọta B (65:35)
Ngwọta nke dabara na sistemụ: 1.5 mg/mL nke USP Carvedilol System Suitability Mixture RS na Diluent
Ihe ngwọta nlele: 1.5 mg / mL nke Carvedilol na Diluent kwadebere dị ka ndị a.Jiri ihe dị ka 1.9 ml nke diluent kwa mg nke Carvedilol, na sonicate obere oge iji kwado mgbasa.
Sistemụ chromatographic

(Lee Chromatography <621>, Kwesịrị ekwesị Sistemu.)
Ụdị: LC
Ihe nchọpụta: UV 226 nm
Ogidi: 4.6-mm × 30-mm;3-µm nkwakọ ngwaahịa L7
Okpomọkụ kọlụm: 40 ℃
Ọnụego mmiri: 2 ml / min
Nha igba ogwu: 10µL
Sistemu kwesịrị ekwesị
Ọmụma: Ngwọta dabara adaba sistemụ
Kwesịrị ekwesị chọrọ
Mkpebi: NLT 2.0 n'etiti carvedilol na carvedilol metụtara ogige F
Nyocha
Ihe atụ: Ngwọta nlele
Gbakọọ pasent nke carvedilol metụtara ogige F na akụkụ nke nlele emere:
Nsonaazụ = (rU/rT) × (1/F) × 100
rU = nzaghachi kacha elu nke carvedilol metụtara ogige F sitere na ngwọta Sample
rT = Nchikota nzaghachi kacha elu nke carvedilol na carvedilol metụtara compound F sitere na ngwọta Sample
F = Nzaghachi nke ikwu, 1.1
Usoro nnabata: NMT 0.1%
Nnwale akọwapụtara
• Mfu na ihicha <731>: Kpochapụ ihe nlele na 105 ℃ maka awa 3: ọ na-efunahụ NMT 0.5% nke ibu ya.
NKWUO GBASARA YA
• Nkwakọ ngwaahịa na Nchekwa: Chekwaa n'ime akpa siri ike, ma chekwaa na okpomọkụ nke ụlọ a na-achịkwa.
• Labeling: Ọ bụrụ na a na-eji ule maka Organic adịghị ọcha nke HPLC na-abụghị Usoro 1, mgbe ahụ akara ngosi na-ekwu ule nke isiokwu ahụ kwadoro.
• Ụkpụrụ ntụaka USP <11>

USP Carvedilol RS
Ngwakọta jikọrọ USP Carvedilol A RS
1- (4- (2-Hydroxy-3-- (2--methoxyphenoxy) ethylamino) propoxy -9H-carbazol-9-yl) -3- (2- (2-methoxyphenoxy) ethylamino) propan-2- ol.
C36H43N3O7 629.74
Ihe jikọrọ USP Carvedilol B RS
3,3'- (2- (2-Methoxyphenoxy) ethylazanediyl) bis (1- (9H-carbazol-4-yloxy) propan-2-ol).
C39H39N3O6 645.74
Ihe jikọrọ USP Carvedilol Ngwakọta C RS
1- (9H-Carbazol-4-yloxy) -3- (benzyl (2- (2-methoxyphenoxy) ethyl) amino) propan-2-ol.
C31H32N2O4 496.60
Ihe jikọrọ USP Carvedilol D RS
4- (Oxiran-2-ylmethoxy) -9H-carbazole.
C15H13NO2 239.27
Ihe jikọrọ USP Carvedilol E RS
2- (2-Methoxyphenoxy) ethyl amine.
C9H13NO2 167.21
Ngwakọta Ngwakọta Sistemu Carvedilol nke USP Carvedilol RS
Ngwakọta nke ihe dịka 0.1% carvedilol metụtara ogige F (1- (2- (2-Methoxyphenoxy) ethylamino) -3- (2,3,4,9-tetrahydro-1H-carbazol-5-yloxy) propan-2-ol) na matriks nke carvedilol ọgwụ ihe.
Dee ozi gị ebe a ziga anyị ya