Carvedilol Phosphate Hemihydrate CAS 610309-89-2 Dị Ọcha> 99.0% (HPLC)

Carvedilol Phosphate Hemihydrate (CAS: 610309-89-2) bụ onye na-egbochi α1-receptor na onye na-adịghị ahọrọ β-receptor blocker, enweghị ọgwụ Sympathimetic na-arụ ọrụ, bioavailability nke 10 ~ 47%, anaghị emetụta nri, mmetụta na α1. -receptor bụ nke ukwuu ala karịa β1-na β2-anabata, ike ike nke β 1-na β 2-nnabata mgbochi bụ 1:10 ~ 1:100.Mmetụta nke mgbochi β 1-receptor bụ ihe dịka 1/2 nke labetalol, na mgbochi α1 ya adịghị ike karịa prazosin.Ọ nwere ike ịgbasa arịa ọbara, belata nguzogide vaskụla dị n'akụkụ, gbasaa akwara akwara na akwara, ma belata nrụgide nke akpa ume.O nwere mmetụta nchebe doro anya na hypoxia myocardial na mmerụ ahụ myocardial kpatara site na infarction myocardial, nke nwere ike jikọta na igbochi β-receptor, nke nwere ike ibelata mbelata glycogen myocardial na mmụba nke pH, ma belata nha infarct.
A na-eji Carvedilol Phosphate Hemihydrate na-agwọ ọbara mgbali elu dị nro ma na-agafeghị oke, enwere ike iji ya naanị ya ma ọ bụ yana ọgwụ mgbochi ndị ọzọ (karịsịa thiazide diuretics).Maka mgbakasị obi mgbakasị na-adịghị ala ala.
Carvedilol Phosphate Hemihydrate bụ onye na-egbochi nnabata β/α-1 anaghị ahọpụta.Carvedilol na-egbochi peroxidation lipid na IC50 nke 5 μM.Carvedilol bụ onye na-ahụ maka mgbochi hypertensive nwere ọtụtụ ebumnuche nwere ike ịmụ maka angina pectoris na nkụchi obi.