Daclatasvir Dihydrochloride Intermediate CAS 1007882-23-6 Ịdị Ọcha>98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd bụ onye na-emepụta ihe nke Daclatasvir Dihydrochloride Intermediate (CAS: 1007882-23-6) nwere àgwà dị elu.Ruifu Chemical nwere ike ịnye nnyefe zuru ụwa ọnụ, ọnụahịa asọmpi, obere na nnukwu ọnụọgụ dị.Ịzụta Daclatasvir Dihydrochloride Intermediates,Please contact: alvin@ruifuchem.com
| Aha Chemical | Di-tert-Butyl (2S,2'S) -2,2'-(4,4'-Biphenyldiylbis(1H-imidazole-5,2-diyl))di(1-Pyrrolidinecarboxylate) |
| Ụdị okwu | Daclatasvir Intermediate Ⅱ;Dacaltasvir Intermediate 02;Daclatasvir T-Butyl Ester;Bis (2-Methyl-2-Propanyl) (2S,2'S) -2,2'- [4,4'-Biphenyldiylbis (1H-Imidazole-4,2-diyl)] di (1-Pyrrolidinecarboxylate);Di-tert-butyl 2,2′-([1,1′-Biphenyl]-4,4′-diylbis(1H-Imidazole-5,2-diyl))(2S,2'S)-bis(Pyridineidine-1- Carboxylate;(2S,2'S)-2,2'-([1,1'-Biphenyl]-4,4'-diyldi-1H-Imidazole-5,2-diyl)bis-1-Pyrrolidinecarboxylic Acid 1,1'-Bis (1,1-Dimethylethyl) Ester;Daclatasvir adịghị ọcha 4 |
| Ọnọdụ Ahịa | Na ngwaahịa, Mmepụta Azụmahịa |
| Nọmba CAS | 1007882-23-6 |
| Usoro ihe omimi | C40H51ClN8O6 |
| Ibu molekụla | 775.35 g/mol |
| Ebe esi nri | 890.2± 65.0 ℃ na 760 mmHg |
| Njupụta | 1.220±0.06 g/cm3 |
| COA & MSDS | Dị |
| Mmalite | Shanghai, China |
| Otu | Ọkara nke Daclatasvir Dihydrochloride (CAS: 1009119-65-6) |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta | Nsonaazụ |
| Ọdịdị | Icha odo odo na ntụ ntụ odo | Ntụ ntụ edo edo dị ọkụ |
| Ọnwụ na ihicha | <1.00% | 0.65% |
| Oke adịghị ọcha otu | <1.00% | 0.45% |
| Mgbakọta adịghị ọcha | <2.00% | 1.24% |
| Ụzọ ịdị ọcha / nyocha | > 98.0% (HPLC) | 98.76% |
| Spectrum infrared | Nkwekọ na Structure | Na-akwado |
| 1H NMR Spectrum | Nkwekọ na Structure | Na-akwado |
| Mmechi | A nwalela ngwaahịa a wee kwado nkọwa ndị enyere | |
| Ngwa | Ọkara nke Daclatasvir Dihydrochloride (CAS: 1009119-65-6) | |
ngwugwu:Fluorinated Bottle, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Debe akpa ahụ nke ọma ma debe ya n'ụlọ nkwakọba ihe dị jụụ, kpọrọ nkụ na nke ikuku na-ekpo ọkụ n'ebe ihe na-adabaghị adaba.Chebe site na ìhè na mmiri mmiri.
Mbupu:Jiri ikuku na-ebuga ụwa niile site na FedEx / DHL Express.Nye nnyefe ngwa ngwa na ntụkwasị obi.
Kedu ka esi azụta?Biko kpọtụrụDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Ahụmịhe afọ 15?Anyị nwere ihe karịrị 15 afọ nke ahụmahụ na mmepụta na mbupụ nke a dịgasị iche iche nke elu mma pharmaceutical intermediates ma ọ bụ ezi kemịkal.
Isi ahịa?Na-ere ahịa ụlọ, North America, Europe, India, Korea, Japanese, Australia, wdg.
Uru?Ogo kachasị elu, ọnụ ahịa dị ọnụ ala, ọrụ ọkachamara na nkwado teknụzụ, nnyefe ngwa ngwa.
OgoNkwenye?Usoro njikwa mma siri ike.Ngwá ọrụ ọkachamara maka nyocha gụnyere NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, wdg.
Ihe atụ?Ọtụtụ ngwaahịa na-enye ihe nlele efu maka nyocha dị mma, ndị ahịa kwesịrị ịkwụ ụgwọ mbupu.
Nyocha ụlọ ọrụ?Nnabata nyocha ụlọ ọrụ.Biko mee oge oge tupu oge eruo.
MOQ?Enweghị MOQ.A na-anabata obere usoro.
Oge Mbuga ozi? Ọ bụrụ n'ime ngwaahịa, ekwenyere nnyefe ụbọchị atọ.
Ụgbọ njem?Site Express (FedEx, DHL), nke ikuku, site n'oké osimiri.
Akwụkwọ?Mgbe ọrụ ahịa gasịrị: COA, MOA, ROS, MSDS, wdg nwere ike ịnye.
Synthesis omenala?Nwere ike ịnye ọrụ nhazi ahaziri iche ka ọ dabara mkpa nyocha gị nke ọma.
Usoro ịkwụ ụgwọ?A ga-ebu ụzọ ziga akwụkwọ ọnụahịa Proforma mgbe nkwenye nke iwu, kpuchiri ozi ụlọ akụ anyị.Ịkwụ ụgwọ site na T/T (Telex Nyefee), PayPal, Western Union, wdg.
Di-tert-Butyl (2S,2'S) -2,2'-(4,4'-Biphenyldiylbis(1H-imidazole-5,2-diyl))di (1-Pyrrolidinecarboxylate) (CAS: 1007882-23-6) bụ etiti nke Daclatasvir Dihydrochloride (CAS: 1009119-65-6).
Daclatasvir (Daklinza) enwetala ọnọdụ "nyocha ụzọ", jikọtara ya na Sorafenib maka ọgwụgwọ genotype III ndị okenye nwere ọrịa ịba ọcha n'anya C. Daklinza bụ ọgwụ mbụ nke egosipụtara na ọ dị irè na ọgwụgwọ genotype III ịba ọcha n'anya C virus. ọrịa na-enweghị njikọ nke interferon ma ọ bụ ribavirin.Interferon na Ribavirin bụ ọgwụ abụọ FDA kwadoro maka ọgwụgwọ nje virus ịba ọcha n'anya C.Ịba ọcha n'anya C bụ ọrịa malitere ịrịa nke nwere ike ibute mbufụt nke imeju, na-ebute mbelata ọrụ imeju ma ọ bụ ọdịda imeju.Ọtụtụ ndị ọrịa butere ịba ọcha n'anya C enweghị ihe mgbaàmà ruo mgbe mmebi imeju pụtara, nke nwere ike were ọtụtụ afọ.N'ụwa niile, genotype III ịba ọcha n'anya C bụ nke abụọ a na-ahụkarị ụdị ọrịa ịba ọcha n'anya C mgbe genotype 1 ịba ọcha n'anya C na-ewere ya dị ka otu n'ime ọrịa genotype ndị na-adịghị agbanwe agbanwe.Daklinza bụ pan-genotype NS5A replication complex inhibitor, yana arụmọrụ nke mgbochi nke mmegharị RNA na mgbakọ nje, mmetụta antiviral abụọ.Maka ọmụmụ ihe in vitro, egosila Daklinza ka ọ nwere mmetụta mgbochi nje megide genotype 1 ~ 6 nje ịba ọcha n'anya C.Daklinza na-esonyere ịdọ aka ná ntị na nchikota nke amiodarone, Daklinza na Sofosbuvir nwere ike ime ka obi dị mbelata nke ukwuu.Daklinza bụ mbadamba ụrọ nke nwere 60 mg akwadoro maka otu ugboro / d, yana njikọta na Sofosbuvir maka ngụkọta nke izu iri na abụọ.
Ụlọ ọrụ nyocha na mmepe: Bristol-Myers Squibb.
Akwụkwọ ikike ikike: WO 2008021927A2 (August 9, 2007).
Oge nke ahịa: July 24, 2015 edepụtara na United States, aha ahia Daklinza.
Ngosipụta: Eji ya na Sofosbuvir agwọ ọrịa ọrịa ịba ọcha n'anya C (HCV) nke genotype 3.
Usoro nke ime ihe: HCV protein nonstructural protein 5A (NS5A) inhibitors.Mmeghachi omume ọjọọ: isi ọwụwa na ike ọgwụgwụ.
Ụdị na nkọwapụta: Mbadamba ụrọ, 30 na 60mg.
