Risperidone CAS 106266-06-2 Assay 98.0 ~ 102.0%
Shanghai Ruifu Chemical Co., Ltd bụ onye na-emepụta Risperidone (CAS: 106266-06-2) nwere oke mma.Ruifu Chemical nwere ike ịnye nnyefe zuru ụwa ọnụ, ọnụahịa asọmpi, ọrụ magburu onwe ya, obere na nnukwu ọnụọgụ dị.Zụrụ Risperidone,Please contact: alvin@ruifuchem.com
| Aha Chemical | Risperidone |
| Ụdị okwu | 3-[2-[4- (6-Fluoro-1,2-Benzisoxazol-3-yl)-1-Piperidinyl] ethyl]-6,7,8,9-Tetrahydro-2-Methyl-4H-Pyrido[1] ,2-a]pyrimidin-4-otu;Risperdal;Risperidal;Risperdal Consta;Rispolept;Risperin;Rispolin;Sequinan;Risperdal M-Tab |
| Ọnọdụ Ahịa | Na ngwaahịa, Mmepụta Azụmahịa |
| Nọmba CAS | 106266-06-2 |
| Usoro ihe omimi | C23H27FN4O2 |
| Ibu molekụla | 410.49 g/mol |
| Ebe Na-agbaze | 170.0 ka 174.0 ℃ |
| Njupụta | 1.38±0.10 g/cm3 |
| Klas Hazard | 6.1;Nsi |
| COA & MSDS | Dị |
| Mmalite | Shanghai, China |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta | Nsonaazụ |
| Ọdịdị | Ọcha ka Gbanyụọ-Ọcha ntụ ntụ | Na-akwado |
| njirimara A | Infrared absorption | Na-akwado |
| njirimara B | Oge njide: kwekọrọ na ihe ntụaka | Na-akwado |
| Ọnwụ na ihicha | <0.50% | 0.12% |
| Ihe fọdụrụ na mgbanye | <0.10% | 0.07% |
| Ọla dị arọ | <0.001% | <0.001% |
| Ngwakọta ndị emetụtara | ||
| E-Oxime | <0.20% | <0.20% |
| Z-Oxime | <0.20% | <0.20% |
| 9-Hydroxyrisperidone | <0.20% | <0.20% |
| 5-Fluororisperidone | <0.20% | <0.20% |
| 6-Methylrisperidone | <0.20% | <0.20% |
| Ọdịghị ọcha ọ bụla amabeghị | <0.10% | <0.10% |
| Mgbakọta adịghị ọcha | <0.30% | <0.30% |
| Nyocha | 98.0 ~ 102.0% (Agbakọnyere na ntọala akpọnwụwo) | 100.52% |
| Mmechi | A nwalela ngwaahịa a wee kwado ụkpụrụ USP 35 | |
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Risperidone
C23H27FN4O2 410.48
4H-Pyrido [1,2-a] pyrimidin-4-otu, 3-[2-[4- (6-fluoro-1,2-benzisoxazol-3-yl) -1-piperidinyl] ethyl]-6,7 ,8,9-tetrahydro-2-methyl-.
3-[2-[4- (6-Fluoro-1,2-benzisoxazol-3-yl) piperidino] ethyl] -6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-otu [106266-06-2].
»Risperidone nwere ihe na-erughị 98.0 pasent na ọ bụghị karịa 102.0 pasent nke C23H27FN4O2, gbakọọ na akpọnwụwo ndabere.
Nkwakọ ngwaahịa na nchekwa - Chekwaa n'ime igbe emechiri nke ọma.Na-echekwa na ụlọ okpomọkụ.
Ụkpụrụ ntụaka USP <11>-
USP Risperidone RS
3-[2-[4- (6-fluoro-1,2-benzisoxazol-3-yl) piperidino] ethyl] -6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-otu 410.48 CAS-106266-06-2
Ngwakọta Ngwakọta Sistemụ USP Risperidone dabara adaba
Nwere risperidone na ihe dịka 0.2% nke nke ọ bụla n'ime ihe ndị a:
Z-Oxime-3-[2-[4-[(Z)-(2,4-difluorophenyl) (hydroxyimino) methyl] piperidin-1-yl] ethyl] -2-methyl-6,7,8,9- tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-otu.
9-Hydroxyrisperidone- (6RS) -3-[2-[4- (6-fluoro-1,2-benzisoxazol-3-yl) piperidin-1-yl] ethyl] -2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-otu.
6-Methylrisperidone- (6RS) -3-[2-[4- (6-fluoro-1,2-benzisoxazol-3-yl) piperidin-1-yl] ethyl] -2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-otu.
[Rịba ama- Ngwakọta a nwere risperidone, Z-oxime, 9-hydroxyrisperidone, na 6-methylrisperidone.]
njirimara-
A: Infrared absorption <197K>.
B: Oge njide nke nnukwu ọnụ ọgụgụ dị elu na chromatogram nke nkwadebe Assay kwekọrọ na nke ahụ na chromatogram nke nkwadebe Standard, dị ka enwetara na Assay.
Ọnwụ na ihicha <731>- Akọrọ na agụụ na 80 maka awa 4: ọ na-efunahụ ihe karịrị 0.5% nke ibu ya.
Ihe fọdụrụ na mgbanye <281>: ọ bụghị ihe karịrị 0.1%, a na-eji ụdị nnwale 2.0g.
Ọla dị arọ, Usoro II <231>: 0.001%.
Ngwakọta ndị emetụtara-
Ngwọta nchekwa, Ngwọta A, Ngwọta B, Usoro mkpanaaka, Diluent, Ngwọta dabara adaba sistemu, na sistemụ Chromatographic- Kwadebe dị ka enyere ya na Assay.
Ọkọlọtọ ngwọta-Jiri nkwadebe Ọkọlọtọ, akwadoro dịka enyere ya na nyocha.
Ngwọta nwale-Jiri nkwadebe Assay.
Usoro-Tinye nha nha nha nha (ihe dịka 10 µL) nke ọkọlọtọ ọkọlọtọ na ngwọta nnwale n'ime chromatograph, wee dekọọ chromatogram.Chọpụta ihe ndị na-adịghị ọcha site na iji oge njide ikwu nke enyere na Tebụl 1, wee tụọ nzaghachi kacha elu.Gbakọọ pasent nke ngwakọta risperidone ọ bụla metụtara na mpaghara Risperidone nke usoro a were were:
100 (CS / CU) (rU / rS) (1/F)
nke CS na CU bụ mkpokọta, na mg kwa mL, nke risperidone na ngwọta Standard na ngwọta ule n'otu n'otu;rU bụ mpaghara kachasị elu nke adịghị ọcha ọ bụla enwetara site na ngwọta ule;rS bụ mpaghara kachasị elu nke risperidone nwetara site na ngwọta Standard;na F bụ ihe nzaghachi nzaghachi maka adịghị ọcha ọ bụla metụtara risperidone.Na mgbakwunye na ịgafeghị oke na Tebụl 1, ọ bụghị ihe karịrị 0.10% nke adịghị ọcha ọ bụla a na-amaghị (jiri uru F nke 1.0) na-achọta ma ọ bụghị karịa 0.30% nke mkpokọta adịghị ọcha.Echefula ọnụ ọgụgụ adịghị ọcha na-erughị 0.05%.
Tebụl 1
Oge Njide Mgbakwunye Njikọ emetụtara (RRT) Ihe Nzaghachi Ọdịnaya (F) Oke (%)
E-oxime1 0.60 1.0 NMT 0.20
Z-oxime2 0.67 0.63 NMT 0.20
9-hydroxyrisperidone3 0.76 0.92 NMT 0.20
5-fluororisperidone4 0.94 1.0 NMT 0.20
Risperidone 1.0 1.0 -
6-methylrisperidone5 1.2 0.95 NMT 0.20
1 3-[2-[4- (E) (2,4-Difluorophenyl) (hydroxyimino) methyl] piperidin-1-yl] ethyl] -2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a] pyrimidin-4-otu
2 3-[2-[4-[(Z) (2,4-Difluorophenyl) (hydroxyimino) methyl] piperidin-1-yl] ethyl] -2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a] pyrimidin-4-otu
3 (9RS) -3-[2-[4- (6-Fluoro-1,2-benzisoxazol-3-yl) piperidin-1-yl] ethyl] -9-hydroxy-2-methyl-6,7,8 ,9-tetrahydro-4H-pyrido[1,2-a] pyrimidin-4-otu
4 3-[2-[4- (5-Fluoro-1,2-benzisoxazol-3-yl) piperidin-1-yl] ethyl] -2-methyl-6,7,8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-otu
5 (6RS) -3-[2-[4- (6-Fluoro-1,2-benzisoxazol-3-yl) piperidin-1-yl] ethyl] -2,6-dimethyl-6,7,8,9 -tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-otu
Nyocha -
Ngwọta nchekwa - gbazee 15.4 g nke ammonium acetate na 1 L mmiri.Gbanwee ya na 10% acetic acid na pH nke 6.5, ma gwakọta ya.
Ngwọta A-Mix 100 ml nke ihe ngwọta na 150 ml nke methanol na 1000-mL volumetric flask, na itughari na mmiri ka olu.
Ngwọta B- Gwakọta 100 ml nke ihe ngwọta na 850 ml nke methanol na flask volumetric 1000-mL, ma jiri mmiri na-atụgharị na olu.
Usoro mkpanaaka-Jiri ngwakọta agbanwe agbanwe nke Ngwọta A na Ngwọta B dịka akwadoro maka sistemụ Chromatographic.Mee mgbanwe ọ bụrụ na ọ dị mkpa (lee Dabara Sistemu n'okpuru Chromatography 621).
Diluent-gwakọta 100 ml nke ihe ngwọta na mmiri 900 ml na 1000 ml nke methanol.
Ngwọta dabara adaba sistemụ- Kwadebe 1 mg kwa ml nke USP Risperidone System Suitability Mixture RS na Diluent.
Nkwadebe ọkọlọtọ-Kwụsa ọnụọgụ USP Risperidone RS nke a tụrụ n'ụzọ ziri ezi na diluent, ma na-atụgharị n'ụzọ dị iche iche, yana n'usoro ma ọ bụrụ na ọ dị mkpa, na Diluent iji nweta ngwọta nwere njiri mara nke ihe dịka 1.0 mg kwa ml.
Nkwadebe nke assay-gbarisịa ọnụọgụ Risperidone a tụrụ n'ụzọ ziri ezi na diluent, ma na-atụgharị ọnụ n'ụzọ dị iche iche, na nzọụkwụ ọ bụla ma ọ bụrụ na ọ dị mkpa, na Diluent iji nweta ngwọta nwere mkpokọta ihe dịka 1.0 mg kwa ml.
Usoro Chromatographic (lee Chromatography <621>) - chromatograph mmiri mmiri nwere ihe nchọpụta 275-nm yana kọlụm 4.6mm × 10-cm nke nwere 3-µm mbukota L1.Onu ogugu a bu ihe dika 1.5 ml kwa nkeji.A na-edobe okpomọkụ kọlụm na 35. A na-ahazi chromatograph dị ka ndị a.
Oge (nkeji) Ngwọta A (%) Ngwọta B (%) Elution
0–1 70 30 isocratic
1–20 70®5 30®95 gradient ahịrị
20–25 5 95 isocratic
25–27 5®70 95®30 gradient linear
27–35 70 30 re-equilbrationTinye ihe ngwọta dabara na sistemụ.Dekọọ nzaghachi kachasị elu dị ka eduzi ya maka Usoro, ma chọpụta ọnụ ọgụgụ kachasị elu n'ihi Z-oxime, 9-hydroxyrisperidone, 6-methylrisperidone, na risperidone site na iji oge njigide oge (RRT) site na Tebụl 1;mkpebi, R, n'etiti Z-oxime na 9-hydroxyrisperidone abụghị ihe na-erughị 2.8;ihe ọdụdụ maka risperidone abụghị ihe karịrị 1.5;na ngbanwe ọkọlọtọ maka ntụtụ oyiri abụghị ihe karịrị 2.0% maka ọnụ ọgụgụ risperidone.
Usoro- Wepụ iche nha nha nha (ihe dị ka 10 µL) nke nkwadebe ọkọlọtọ na nkwadebe Assay n'ime chromatograph, wee tụọ nzaghachi maka ọnụ ọgụgụ risperidone.Gbakọọ ọnụ ọgụgụ, na pasent nke C23H27FN4O2, na akụkụ nke Risperidone nke usoro a were:
100 (CS / CU) (rU / rS)
nke CS na CU bụ mkpokọta, na mg kwa mL, nke risperidone na nkwadebe Standard na nkwadebe Assay, n'otu n'otu;na rU na rS bụ nzaghachi kacha elu enwetara site na nkwadebe Assay na nkwado ọkọlọtọ, n'otu n'otu.
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Nọmba UN 3249
WGK Germany 3
RTECS UV1164800
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Klas 6.1 (a) egwu
Otu nkwakọ ngwaahịa II
Risperidone (CAS: 106266-06-2) nwere mmetụta antagonism na ndị na-anabata 5HT2 na ndị na-anabata D2.A na-eji Risperidone mee ihe maka nnukwu ọrịa schizophrenia na-adịghị ala ala.Ọgwụ antipsychotic.A na-eji Risperidone maka ọgwụgwọ ọrịa schizophrenia siri ike na nke na-adịghị ala ala na ọnọdụ ndị ọzọ dị iche iche nke psychotic doro anya mgbaàmà dị mma (dị ka ịhụ anya, echiche efu, nsogbu echiche, iro, nrutuaka) na mgbaàmà ọjọọ dị ịrịba ama (dị ka enweghị nzaghachi, enweghị mmasị nke mmetụta uche na enweghị mmasị na ọha mmadụ, nke ole na ole. okwu).O nwekwara ike ibelata mgbaàmà na-emetụta schizophrenia (dịka: ịda mbà n'obi, obi amamikpe, nchekasị).Maka ndị ọrịa Risperidone dị irè maka ọgwụgwọ siri ike, na usoro nlekọta ọgwụgwọ, Risperidone nwere ike ịga n'ihu na-arụ ọrụ ụlọ ọgwụ ya.Risperidone, ya mere, nwere ọgwụgwọ ọgwụgwọ na ma mgbaàmà dị mma na nke na-adịghị mma nke schizophrenia ma na-emepụta mmetụta dị nta nke nta ka ọ bụrụ ihe mgbaàmà extrapyramidal ma e jiri ya tụnyere D2 antagonist antipsychotics.O nwekwara ikike maka njikwa mwepu mmanya na-aba n'anya na ọgwụ cocaine.
