CAS 177036-94-1 Ịdị Ọcha>99.0% (HPLC) API Ụlọ Ọrụ Dị Ọcha Dị Elu

(CAS: 177036-94-1) APIbụ onye na-anabata endothelin-A (ETA) antagonist nke ewepụtara maka ọgwụgwọ ọnụ nke ndị ọrịa nwere ọbara mgbali elu pulmonary arterial (PAH), iji meziwanye ikike mmega ahụ na igbu oge na-akawanye njọ.PAH bụ ọrịa na-adịghị ahụkebe nke obere akwara pulmonary nke e ji na-amụba vaskụla na imezigharị ya, na-eme ka mmụba na-aga n'ihu na nkwụsị nke pulmonary vascular na nrụgide pulmonary arterial, na n'ikpeazụ, ọdịda ventricular ziri ezi na ọnwụ akaghi aka.Mgbaàmà mbụ nke PAH gụnyere mmalite nke mkpụmkpụ ume nke nta nke nta, ike ọgwụgwụ, palpitation, edema, na ịda mbà n'obi.Endothelin-1 (ET-1), vasoconstrictor nwere ike na mitogen muscle dị nro, bụ isi ihe na-enye aka na mmụba nke ọrịa ahụ, a na-agbanyekwa mmetụta ya site na ịgbalite ETA na ndị na-anabata ETB.Na June nke 2007, FDA nyere nkwado nke (CAS: 177036-94-1) API maka ọgwụgwọ PAH otu ugboro kwa ụbọchị.