1- (3-Methoxypropyl) -4-Piperidinamine CAS 179474-79-4 Prucalopride Succinate Intermediate Dị Ọcha>98.0% (GC)

Ngwaahịa a bụ 1- (3-Methoxypropyl) -4-Piperidinamine.Nwere C9H20N2O agaghị erughị 98.0%, gbakọọ na anhydrous ndabere.
[Njirimara: Ngwaahịa a enweghị ụcha ka ọ dị obere mmiri mmiri edo edo.
Were mmiri kwesịrị ekwesị nke ngwaahịa a, gbakwunye ihe mgbaze (methanol), gbazee ya, chọpụta ya dị ka usoro mkpebi mmiri si dị (Ihe mgbakwunye Ⅷ M, usoro mbụ A), jiri ule Fisher tụlee iji chọpụta ruo mgbe ngwọta gbanwere site na ìhè edo edo. na-acha uhie uhie aja aja na-egosi njedebe njedebe, ma mee ule ọzọ efu.Gbakọọ dịka usoro a si dị: ọdịnaya mmiri ekwesịghị gafere 1.0%.
Ọdịnaya mmiri (%) = (AB) F/W×100%
Ebe, A bụ olu mmiri mmiri Fisher nke ngwaahịa nnwale ahụ riri (ml);
B bụ olu nke mmiri ule Fisher nke oghere oghere na-eri, ml;
F bụ ịdị arọ nke ngwọta ule Fisher dabara na mmiri kwa 1ml, mg;
W bụ arọ nke ngwaahịa nnwale, mg
Otu adịghị ọcha
Dị ka ọnọdụ nchọpụta na ụzọ dị n'okpuru [mkpebi ọdịnaya], e dekọrọ chromatogram na oge njigide site na isi elu bụ ugboro 3.Ọ bụrụ na enwere oke adịghị ọcha na ngwọta nnwale, otu adịghị ọcha agaghị agafe 0.5% na nchikota adịghị ọcha niile agaghị abụ ihe karịrị 2.0% dịka usoro nhazi mpaghara si dị.
[Mkpebi ọdịnaya] Dị ka usoro mkpebi ihe mgbaze fọdụrụnụ si dị (Ihe mgbakwunye Ⅷ P)
(6%) cyanopropyl phenyl - (94%) dimethylpolysiloxane (ma ọ bụ polarity yiri ya) dị ka kọlụm capillary mmiri edozi;
A na-eji usoro ikpo ọkụ emebere nke kọlụm capillary headspace sample nke nwere ọnọdụ chromatographic gas.Okpomọkụ mbụ ahụ bụ 100 ℃ maka nkeji 5, ewelitere okpomọkụ na 15℃ kwa nkeji ruo 250℃ maka 4min.The mbata okpomọkụ bụ 250 ℃, na detector okpomọkụ bụ 280 ℃.Ọnụego ya bụ 4ml/min.Oke shunt bụ 8: 1.
A na-ewere ihe dị ka 0.6g nke ngwaahịa a, tụọ ya nke ọma, tinye ya na karama 10ml, gbazere na methanol ma gwakọta ya na ọnụ ọgụgụ, dị ka ngwọta ngwaahịa ule.A na-agbanye ihe nlele ahụ na 1μl opekata mpe ugboro abụọ n'usoro, n'otu n'otu.Ekpebiri mpaghara kacha elu nke a ga-atụ.Isi ịdị ọcha kacha elu erughị 98.0% dịka usoro nhazi mpaghara kacha elu si dị.