6,7-Bis (2-Methoxyethoxy) -4 (3H) -Quinazolinone CAS 179688-29-0 Erlotinib Hydrochloride Intermediate Ọcha>99.0% (HPLC)
Onye na-emepụta ihe na onye na-ebubata Erlotinib Hydrochloride Intermediates
Erlotinib Hydrochloride CAS 183319-69-9
3-Ethynylaniline CAS 54060-30-9
6,7-Bis (2-Methoxyethoxy) -3H-Quinazolin-4-otu CAS 179688-29-0
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| Aha Chemical | 6,7-Bis (2-Methoxyethoxy) -3H-Quinazolin-4-otu |
| Ụdị okwu | 6,7-Bis (2-Methoxyethoxy) -4 (3H) - Quinazolinone;6,7-Bis (2-Methoxyethoxy) -3,4-Dihydroquinazolin-4-otu;6,7-Bis (2-Methoxyethoxy) -4-Hydroxyquinazoline;6,7-Bis (2-Methoxyethoxy) -4-Quinazolinol;CP-380736 |
| adịghị ọcha | Erlotinib adịghị ọcha A;Erlotinib Lactam adịghị ọcha |
| Nọmba CAS | 179688-29-0 |
| Nọmba CAT | RF2685 |
| Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
| Usoro ihe omimi | C14H18N2O5 |
| Ibu molekụla | 294.31 |
| Ebe Na-agbaze | 190.0 ka 194.0 ℃ |
| Njupụta | 1.26±0.1 g/cm3 |
| Mmetụta | Mmetụta ikuku |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta |
| Ọdịdị | Ọcha ma ọ bụ Gbanyụọ-Ọcha ntụ ntụ |
| Ụzọ ịdị ọcha / nyocha | > 99.0% (HPLC) |
| Ebe Na-agbaze | 190.0 ka 194.0 ℃ |
| Ọnwụ na ihicha | <0.50% |
| Ihe fọdụrụ na mgbanye | <0.20% |
| Ihe ndị emetụtara nke HPLC | |
| Ọdịghị ọcha nke Onwe Onye | <0.50% |
| Mgbakọta adịghị ọcha | <1.00% |
| Ọla dị arọ | <10ppm |
| Spectrum infrared | Dabara na Ọdịdị |
| Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
| Ojiji | Ọkara nke Erlotinib Hydrochloride (CAS: 183319-69-9) |
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6,7-Bis (2-Methoxyethoxy) -3H-Quinazolin-4-otu (CAS: 179688-29-0) bụ etiti nke Erlotinib Hydrochloride (CAS: 183319-69-9).Erlotinib Hydrochlorate bụ obere molecule tyrosine kinase inhibitor nke na-eme mgbanwe na ndị na-anabata ihe na-eto eto epidermal, hydrochloride nke erlotinib, ọgwụ ezubere iche.Ndị nchịkwa nri na ọgwụ ọjọọ nke US (FDA) akwadoro erlotinib (Tarceva) yana gemcitabine dịka ọgwụgwọ mbụ maka ọrịa cancer pancreatic dị elu na mpaghara metastatic.A na-ejikarị ya dị ka ọgwụgwọ nke abụọ ma ọ bụ nke atọ maka ọrịa cancer akpa ume na mpaghara ma ọ bụ metstatic na-abụghị obere cell (NSCLC) yana dịka ọgwụgwọ maka ọrịa cancer pancreatic.A na-eji ya dị ka ihe mgbochi tyrosine maka ọgwụgwọ NSCLC.Obere ogige molecular Erlotinib Hydrochlorate bụ tyrosine kinase receptor inhibitor nke na-egbochi mgbasa nke mkpụrụ ndụ tumo site na igbochi phosphorylation, na-ejikọta na ngalaba catalytic intracellular nke tyrosine kinase na asọmpi na ATP, si otú a na-egbochi ntụgharị mgbaàmà ala na igbochi ọrụ nke ligand tumor cell ligand dabere. HER-1/EGFR.
