Pramipexole Dihydrochloride Monohydrate CAS 191217-81-9 Assay 98.0 ~ 102.0%
Ruifu Chemical bụ onye na-emepụta Pramipexole Dihydrochloride Monohydrate (CAS: 191217-81-9) nwere oke mma.Ruifu Chemical nwere ike ịnye nnyefe zuru ụwa ọnụ, ọnụahịa asọmpi, ọrụ magburu onwe ya, obere na nnukwu ọnụọgụ dị.Zụrụ Pramipexole Dihydrochloride Monohydrate,Please contact: alvin@ruifuchem.com
| Aha Chemical | Pramipexole Dihydrochloride Monohydrate |
| Ụdị okwu | Pramipexole DiHCL Monohydrate;Pramipexole 2HCl monohydrate;(S) -2-Amino-4,5,6,7-Tetrahydro-6- (Propylamino) benzothiazole Dihydrochloride Monohydrate |
| Ọnọdụ Ahịa | Na ngwaahịa, Mmepụta Azụmahịa |
| Nọmba CAS | 191217-81-9 |
| CAS metụtara | 104632-25-9 & 104632-26-0 |
| Usoro ihe omimi | C10H17N3S·2HCl·H2O |
| Ibu molekụla | 302.26 g/mol |
| Ebe Na-agbaze | 290 ℃ (Dec.) |
| Ntụgharị a kapịrị ọnụ [a]20/D | -65.0° ruo -71.0° (C=1 na MeOH)(calcd.on anh.ihe) |
| Mmiri Solubility | Soluble na Mmiri |
| Solubility | Soluble na methanol.Ethanol dị obere.Dichloromethane anaghị agbaze |
| COA & MSDS | Dị |
| Mmalite | Shanghai, China |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta | Nsonaazụ |
| Ọdịdị | Ọcha ka Gbanyụọ-Ọcha ntụ ntụ | Ọcha ntụ ntụ |
| Nyocha (nke HPLC) | 98.0 ~ 102.0% | 99.34% |
| Mmiri nke Karl Fischer | 4.5-6.5% | Na-akwado |
| Ihe fọdụrụ na mgbanye | ≤0.10% | <0.10% |
| Ọla dị arọ (Pb) | ≤10ppm | <10ppm |
| Pramipexole Propionamidea | ≤0.15% | Na-akwado |
| Ngwakọta metụtara Pramipexole A | ≤0.15% | Na-akwado |
| N-Propylpramipexole | ≤0.15% | Na-akwado |
| Pramipexole Dimer | ≤0.15% | Na-akwado |
| Ọdịghị ọcha n'otu n'otu ọ bụla ọzọ amabeghị | ≤0.10% | Na-akwado |
| Enantiomeric ịdị ọcha | ≤1.00% | Na-akwado |
| Palladium | ≤5ppm | <5ppm |
| Spectrum infrared | Nkwekọ na Structure | Na-akwado |
| 1H NMR Spectrum | Nkwekọ na Structure | Na-akwado |
| Mmechi | A nwalela ngwaahịa a wee kwado nkọwa ndị enyere | |
ngwugwu:Fluorinated Bottle, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Debe akpa ahụ nke ọma ma chekwaa n'ebe dị jụụ, kpọrọ nkụ (2 ~ 8 ℃) yana ụlọ nkwakọba ihe nke ọma na-esi na ihe ndị na-adabaghị adaba.Chebe site na ìhè na mmiri mmiri.
Mbupu:Jiri ikuku na-ebuga ụwa niile site na FedEx / DHL Express.Nye nnyefe ngwa ngwa na ntụkwasị obi.
C10H17N3S·2HCl·H2O 302.26
(S) -2-Amino-4,5,6,7-tetrahydro-6- (propylamino) benzothiazole dihydrochloride monohydrate [191217-81-9].
Nkọwa
Pramipexole Dihydrochloride nwere NLT 98.0% na NMT 102.0% nke C10H19Cl2N3S, gbakọọ na anhydrous ndabere.
Nchọpụta
• A. Infrared Absorption <197A> ma ọ bụ <197M>
Ọnụ ọgụgụ ebili mmiri: <197A>, 3800 cm-1 ruo 650 cm-1;<197M>, 4000 cm-1 ruo 600 cm-1
• B. Oge njide nke nnukwu ọnụ ọgụgụ dị elu na ngwọta Sample dabara na nke pramipexole (S-enantiomer) na ngwọta kwesịrị ekwesị System na ule maka Enantiomeric Purity.
• C. Nnwale njirimara-General, Chloride <191>
Ihe nlele: 1 mg/mL nke Pramipexole Dihydrochloride n'ime mmiri
Usoro nnabata: Zutere ihe achọrọ maka ule nitrate silver
ASSAY
• Usoro
Ngwọta A: igbari 9.1 g nke potassium dihydrogen phosphate na 5.0 g nke sodium 1-octanesulfonate monohydrate na 1 L mmiri.Gbanwee ya na phosphoric acid ka ọ bụrụ pH nke 3.0.
Ngwọta B: Acetonitrile na Ngwọta A (1:1)
Ihe mgbaze: Acetonitrile na Ngwọta A (1:4)
Usoro mkpanaka: Lee tebụl gradient n'okpuru.
Oge (nkeji) Ngwọta A (%) Ngwọta B (%)
0 60 40
15 20 80
15.1 60 40
20 60 40
Ngwọta ndabara sistemu: 1.5 mg/mL nke USP Pramipexole Dihydrochloride RS na 0.8 mg/mL nke USP Pramipexole metụtara Compound A RS na diluent
Ọkọlọtọ ngwọta: 1.5 mg/mL nke USP Pramipexole Dihydrochloride RS na diluent
Ngwọta nlele: 1.5 mg/mL nke Pramipexole Dihydrochloride na diluent
Sistemụ chromatographic
(Lee Chromatography <621>, Kwesịrị ekwesị Sistemu.)
Ụdị: LC
Ihe nchọpụta: UV 264 nm
Ogidi: 4.6-mm × 15-cm;5-µm mbukota L1
Okpomọkụ kọlụm: 40 ± 5
Ọnụego mmiri: 1.5 ml / min
Nha igba ogwu: 5µL
Sistemu kwesịrị ekwesị
Nlereanya: Ngwọta dabara adaba sistemu na ngwọta ọkọlọtọ [Rịba ama-Oge njide metụtara pramipexole A na pramipexole bụ ihe dịka 0.7 na 1.0, n'otu n'otu.]
Kwesịrị ekwesị chọrọ
Mkpebi: NLT 6.0 n'etiti pramipexole metụtara compound A na pramipexole, usoro dabara adaba
Ihe na-akpata ọdụ: NMT 2.0 maka pramipexole, ngwọta dabara adaba sistemụ
Ọkọlọtọ emetụtara: NMT 1.0%, Ọkọlọtọ ngwọta
Nyocha
Ihe atụ: Ngwọta ọkọlọtọ na ngwọta nlele
Gbakọọ pasent C10H19Cl2N3S na akụkụ Pramipexole Dihydrochloride ewepụtara:
Nsonaazụ = (rU/rS) × (CS/CU) × (Mr1/Mr2) × 100
rU = nzaghachi kacha elu sitere na ngwọta Sample
rS = nzaghachi kacha elu sitere na ngwọta Standard
CS = ntinye uche nke USP Pramipexole Dihydrochloride RS na ngwọta ọkọlọtọ (mg/mL)
CU = itinye uche nke ngwọta nlele (mg/mL)
Mr1 = arọ molekụla nke pramipexole dihydrochloride, 284.26
Mr2 = arọ molekụla nke pramipexole dihydrochloride monohydrate, 302.26
Asambodo nnabata: 98.0%-102.0% na ndabere anhydrous
IHE adịghị ọcha
Ihe adịghị ọcha
• Ihe fọdụrụ na mgbanye <281>: NMT 0.10%
• Ọla dị arọ, Usoro m <231>
Ọkọlọtọ ngwọta: Standard Lead Solution, 10 ppm
Ihe ngwọta nlele: Ash 2 g nke Pramipexole Dihydrochloride ruo mgbe ọ fọrọ nke nta ka ọ kpọọ nkụ, enwetara uka carbonized.Dụgharịa ihe fọdụrụnụ, tinye 2.0 ml nke nitric acid gbadoro ụkwụ na 5 tụlee nke sulfuric acid, ma jiri nlezianya kwe ka uzuoku pụta.Na-agbanye ọkụ na 500-600 ruo mgbe carbon na-agbanyụ kpamkpam.Dụgharịa ihe fọdụrụnụ, tinye 4 ml nke 6M hydrochloric acid, kpuchie crucible, ma gbarie n'ime mmiri ịsa mmiri na-esi nri maka 15 min.Wepụ ka nkụ.Tinye otu dobe nke hydrochloric acid na 10 ml nke mmiri ọkụ, ma gbarie maka nkeji 2 ọzọ n'ime mmiri ịsa ahụ.Tinye 6 M amonia ngwọta dropwise ruo mgbe ngwọta bụ adịghị ike alkaline, na mezie na 1 M acetic acid ka a pH nke 3.0-4.0.Wepu ihe ngwọta n'ime 25-mL volumetric flask, na itughari na mmiri na 25 mL site na-asa crucible na nzacha.
Usoro nnabata: NMT 10 ppm
Ihe adịghị ọcha
• Usoro
Ngwọta A, Ngwọta B, Diluent, Usoro mkpanaaka, na sistemu Chromatographic: Gaa n'ihu dịka enyere ya na nyocha.
Ngwọta dabara adaba sistemụ: 7.5 µg/mL nke USP Pramipexole Dihydrochloride RS na 3 μg/mL nke USP Pramipexole Njikọ Njikọ A RS na Diluent
Ọkọlọtọ ngwọta: 1.5 µg/mL nke USP Pramipexole Dihydrochloride RS na diluent
Ngwọta nlele: 1.5 mg/mL nke Pramipexole Dihydrochloride na diluent
Sistemu kwesịrị ekwesị
Nlereanya: Ngwọta dabara adaba sistemu na ngwọta ọkọlọtọ
Kwesịrị ekwesị chọrọ
Mkpebi: NLT 6.0 n'etiti pramipexole metụtara compound A na pramipexole, usoro dabara adaba
Ihe na-akpata ọdụ: NMT 2.0 maka pramipexole, ngwọta dabara adaba sistemụ
Ọkọlọtọ emetụtara: NMT 5.0%, Ọkọlọtọ ngwọta
Nyocha
Ihe atụ: Ngwọta ọkọlọtọ na ngwọta nlele
Gbakọọ pasent nke adịghị ọcha onye ọ bụla na akụkụ Pramipexole Dihydrochloride ewepụtara:
Nsonaazụ = (rU/rS) × (CS/CU) × (Mr1/Mr2) × 100
rU = nzaghachi kacha elu nke adịghị ọcha ọ bụla sitere na ngwọta Sample
rS = nzaghachi kacha elu nke pramipexole sitere na ngwọta ọkọlọtọ
CS = ntinye uche nke USP Pramipexole Dihydrochloride RS na ngwọta ọkọlọtọ (mg/mL)
CU = itinye uche nke pramipexole dihydrochloride monohydrate na ngwọta Sample (mg/mL)
Mr1 = arọ molekụla nke pramipexole dihydrochloride, 284.26
Mr2 = arọ molekụla nke pramipexole dihydrochloride monohydrate, 302.26
Usoro nnabata
Ihe adịghị ọcha n'otu n'otu: Lee Tebụl adịghị ọcha 1.
Mkpokọta adịghị ọcha: NMT 0.5%
Tebụl adịghị ọcha 1
Aha Nkwekọrịta Nkwenye Oge Njido, NMT (%)
Pramipexole propionamidea 0.5 0.15
Ngwakọta metụtara Pramipexole Ab 0.7 0.15
Pramipexole 1.0 -
N-Propylpramipexolec 1.4 0.15
Pramipexole dimerd 1.7 0.15
Ihe ọ bụla ọzọ adịghị ọcha nke onye ọ bụla na-amaghị - 0.10
a (S) -N- (2-Amino-4,5,6,7-tetrahydrobenzothiazol-6-yl) propionamide.
b (S) -4,5,6,7-Tetrahydrobenzothiazole-2,6-diamine.
c (S) -2,6-Dipropylamino-4,5,6,7-tetrahydrobenzothiazole.
d N6,N6'-[2-Methylpentane-1,3-diyl]bis(4,5,6,7-tetrahydrobenzothiazole-2,6-diamine).Nke a bụ dimer nke pramipexole (ngwakọta nke isomers anọ nwere ike ime).
Nnwale akọwapụtara
• Mkpebi mmiri, Usoro I <921>: NLT 4.5% na NMT 6.5%
• Enantiomeric ịdị ọcha
Usoro mkpanaka: n-Hexane, mmanya na-egbu egbu, na diethylamine (850:150:1)
Ngwọta ngwaahịa dabara adaba na sistemụ: 1 mg/mL nke ọ bụla nke USP Pramipexole Dihydrochloride RS na USP Pramipexole Njikọ Njikọ D RS na mmanya kpọrọ nkụ.
Ngwọta ndabara sistemu: 0.01 mg/mL nke ọ bụla nke USP Pramipexole Dihydrochloride RS na USP Pramipexole Njikọ Compound D RS sitere na ngwa ahịa dabara adaba sistemụ na usoro mkpanaka.
Ngwọta ọkọlọtọ ọkọlọtọ: 2.0 mg/mL nke USP Pramipexole Njikọ Njikọ D RS na mmanya kpọrọ nkụ.
Ọkọlọtọ ngwọta: 1.5 µg/mL nke USP Pramipexole Njikọ Compound D RS na usoro mkpanaaka
Ngwọta nlele: 0.3 mg/mL, nke a kwadebere site na igbari Pramipexole Dihydrochloride nha nha kwesịrị ekwesị na 25% nke olu mmanya mmiri kpọnwụrụ akpọnwụ na ịgbanye ya na usoro mkpanaka ruo olu.
Sistemụ chromatographic
(Lee Chromatography 621, Kwesịrị ekwesị Sistemu.)
Ụdị: LC
Ihe nchọpụta: UV 254 nm
Ogidi: 4.6-mm × 25-cm;10-µm nkwakọ ngwaahịa L51
Ọnụego mmiri: 1.5 ml / min
Nlele nha: 75µL
Sistemu kwesịrị ekwesị
Nlereanya: Ngwọta ndabara sistemu [Rịba ama-Oge njide metụtara pramipexole D (R-enantiomer) na pramipexole (S-enantiomer) bụ 0.5 na 1.0 n'otu n'otu.]
Kwesịrị ekwesị chọrọ
Mkpebi: NLT 5.0 n'etiti pramipexole metụtara compound D na pramipexole, usoro dabara adaba
Ihe na-akpata ọdụ: NMT 2.4 maka pramipexole, ngwọta dabara adaba sistemụ
Nyocha
Ihe atụ: Ngwọta ọkọlọtọ na ngwọta nlele
Gbakọọ pasent nke pramipexole metụtara ogige D n'ime akụkụ nke Pramipexole Dihydrochloride ewepụtara:
Nsonaazụ = (rU/rS) × (CS/CU) × 100
rU = nzaghachi kacha elu nke ihe metụtara pramipexole D sitere na ngwọta Sample
rS = nzaghachi kacha elu nke ihe metụtara pramipexole D sitere na ngwọta ọkọlọtọ
CS = itinye uche nke pramipexole metụtara compound D na ọkọlọtọ ọkọlọtọ (mg/mL)
CU = itinye uche nke ngwọta nlele (mg/mL)
Usoro nnabata: NMT 1.0% nke ihe metụtara pramipexole D
• Oke nke Palladium
[Rịba ama-Mee ule a ma ọ bụrụ na palladium bụ adịghị ọcha nke inorganic amaara.]
Ihe mgbaze: 0.1M hydrochloric acid
Ngwọta ọkọlọtọ: 40 µg/L nke palladium na Diluent, sitere na ọkọlọtọ palladium dị maka azụmaahịa maka nnabata atom / plasma jikọtara ọnụ.[Rịba ama - Kwadebe nke ọma ngwọta a dị ka achọrọ n'ụbọchị eji ya.]
Ngwọta nlele: Ka 0,5 g nke Pramipexole Dihydrochloride na flask volumetric 50-mL tinye 5.00 ml nke 1 M hydrochloric acid, wee gbarie na kpo oku.Jụụ na okpomọkụ dị n'ime ụlọ, ma jiri mmiri na-atụgharị na olu.
Ọnọdụ Spectrometric
(Lee Spectrophotometry na Light-Scattering 851).
Ụdị: spectrophotometry absorption atom
Ogologo ebili mmiri nyocha: Palladium emission line na 247.6 nm
oriọna: oghere cathode
Isi mmalite atomization: Igwe ọkụ eserese.[Rịba ama - Soro usoro mmemme nke onye nrụpụta tụrụ aro.]
Nlele nha: 20µL
Oghere: Diluent
Sistemu kwesịrị ekwesị
Ihe atụ: Ngwọta ọkọlọtọ
Kwesịrị ekwesị chọrọ
Ntinye: NLT 0.034
Nyocha
Ihe atụ: Ngwọta ọkọlọtọ na ngwọta nlele
Kpebie ntinye nke palladium na ngwọta Sample site na usoro mgbakwunye ọkọlọtọ.
Usoro nnabata: NMT 5 ppm
NKWUO GBASARA YA
• Nkwakọ ngwaahịa na Nchekwa: Chekwaa n'ime ihe ndị mechiri emechi nke ọma, na-echebe site na mmiri na ìhè.
• Ụkpụrụ ntụaka USP 11
USP Pramipexole Dihydrochloride RS Pịa ka ilele Ọdịdị
Ngwakọta jikọrọ USP Pramipexole A RS
(S) -4,5,6,7-Tetrahydrobenzothiazole-2,6-diamine.
C7H11N3S 169.25
Ihe jikọrọ USP Pramipexole D RS
(R) -2-Amino-4,5,6,7-tetrahydro-6- (propylamino) benzothiazole.
C10H17N3S 211.33
Kedu ka esi azụta?Biko kpọtụrụDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Ahụmịhe afọ 15?Anyị nwere ihe karịrị 15 afọ nke ahụmahụ na mmepụta na mbupụ nke a dịgasị iche iche nke elu mma pharmaceutical intermediates ma ọ bụ ezi kemịkal.
Isi ahịa?Na-ere ahịa ụlọ, North America, Europe, India, Korea, Japanese, Australia, wdg.
Uru?Ogo kachasị elu, ọnụ ahịa dị ọnụ ala, ọrụ ọkachamara na nkwado teknụzụ, nnyefe ngwa ngwa.
OgoNkwenye?Usoro njikwa mma siri ike.Ngwá ọrụ ọkachamara maka nyocha gụnyere NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, wdg.
Ihe atụ?Ọtụtụ ngwaahịa na-enye ihe nlele efu maka nyocha dị mma, ndị ahịa kwesịrị ịkwụ ụgwọ mbupu.
Nyocha ụlọ ọrụ?Nnabata nyocha ụlọ ọrụ.Biko mee oge oge tupu oge eruo.
MOQ?Enweghị MOQ.A na-anabata obere usoro.
Oge Mbuga ozi? Ọ bụrụ n'ime ngwaahịa, ekwenyere nnyefe ụbọchị atọ.
Ụgbọ njem?Site Express (FedEx, DHL), nke ikuku, site n'oké osimiri.
Akwụkwọ?Mgbe ọrụ ahịa gasịrị: COA, MOA, ROS, MSDS, wdg nwere ike ịnye.
Synthesis omenala?Nwere ike ịnye ọrụ nhazi ahaziri iche ka ọ dabara mkpa nyocha gị nke ọma.
Usoro ịkwụ ụgwọ?A ga-ebu ụzọ ziga akwụkwọ ọnụahịa Proforma mgbe nkwenye nke iwu, kpuchiri ozi ụlọ akụ anyị.Ịkwụ ụgwọ site na T/T (Telex Nyefee), PayPal, Western Union, wdg.
H
A na-eji Pramipexole Dihydrochloride Monohydrate (CAS: 191217-81-9).
