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Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro[(4-Methoxyphenyl) hydrazono] acetate Dị ọcha ≥99.0% (HPLC)
Ruifu Chemical bụ onye na-ebute ụzọ nke Ethyl Chloro [(4-Methoxyphenyl) hydrazono] acetate (CAS: 27143-07-3) nwere àgwà dị elu, etiti nke Apixaban (CAS: 503612-47-3).Ruifu nwere ike ịnye nnyefe zuru ụwa ọnụ, ọnụahịa asọmpi, obere na nnukwu ọnụọgụ dị.Ịzụta ndị etiti Apixaban, ozi-e: alvin@ruifuchem.com
| Aha Chemical | Ethyl Chloro [(4-Methoxyphenyl) hydrazono] acetate |
| Ụdị okwu | Ethyl 2-Chloro-2-[2- (4-Methoxyphenyl) hydrazono] acetate;(Z) -Ethyl 2-Chloro-2- (2- (4-Methoxyphenyl) hydrazono) acetate;2-Chloro-2-[2- (4-Methoxyphenyl) hydrazinylidene];Apixaban-2;Apixaban adịghị ọcha 3 |
| Ọnọdụ Ahịa | Na ngwaahịa, Mmepụta Azụmahịa |
| Nọmba CAS | 27143-07-3 |
| Usoro ihe omimi | C11H13ClN2O3 |
| Ibu molekụla | 256.69 g/mol |
| Ebe Na-agbaze | 94 ℃ |
| Njupụta | 1.23 |
| COA & MSDS | Dị |
| Mmalite | Shanghai, China |
| Otu | Ọkara nke Apixaban (CAS: 503612-47-3) |
| Ụdị | Ruifu Chemical |
| Ihe | Ụkpụrụ nyocha | Nsonaazụ |
| Ọdịdị | Icha odo odo na ntụ ntụ odo | Na-akwado |
| Ọnwụ na ihicha | <0.50% | 0.23% |
| Ụzọ ịdị ọcha / nyocha | ≥99.0% (HPLC) | 99.3% |
| Spectrum infrared | Dabara na Ọdịdị | Na-akwado |
| 1 H NMR Spectrum | Nkwekọ na Structure | Na-akwado |
| Mmechi | A nwalela ngwaahịa a wee kwado nkọwa ndị enyere | |
ngwugwu:Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Debe akpa ahụ nke ọma ma chekwaa n'ebe dị jụụ, kpọrọ nkụ (2 ~ 8 ℃) yana ụlọ nkwakọba ihe nke ọma na-esi na ihe ndị na-adabaghị adaba.Chebe site na ìhè na mmiri mmiri.
Mbupu:Jiri ikuku na-ebuga ụwa niile site na FedEx / DHL Express.Nye nnyefe ngwa ngwa na ntụkwasị obi.
Ndepụta ihe mgbaze ejiri na nrụpụta
| Mba. | Aha | CAS Mba. | Usoro ihe omimi |
| 1 | Ethyl acetate | Isi: 141-78-6 | C4H8O2 |
| 2 | Dichloromethane | Ọnọdụ: 75-09-2 | CH2Cl2 |
| 3 | Mmanya ethyl | Isi: 64-17-5 | C2H5OH |
5.3.1 Ọdịdị: Ọ kwesịrị ịbụ odo odo na ntụ ntụ.N'anya, debe ngwaahịa nnwale zuru oke (na-enweghị atụ) n'ime efere kristal dị ọcha na okirikiri ọcha (dị ka akwụkwọ ọcha) n'okpuru ọkụ eke.
5.3.2 njirimara: 1H-NMR nwere otu nhazi ahụ dịka ọkọlọtọ.10 ~ 15mg nke ihe nlele ahụ tụbara n'ime tube magnetik nuklia, na 0.5mL nke deuterium DMSO ka agbakwunyere ka ọ gbazee ihe nlele ahụ n'ụzọ zuru ezu, wee jiri ngwá ọrụ resonance magnetik nke ihe karịrị 400MHz nwalee.
5.3.3 Ọnwụ na ihicha: tụọ ihe nlele ahụ gbasara 1.0g wee kpoo ya maka 3h na oven ihicha na 85 ℃.A ga-arụ ọrụ a kapịrị ọnụ maka ngụkọ oke ibu dị ka ndokwa nke SOP-AP-QC-002-01 si kwuo maka Mkpebi Mbelata ibu ibu.
5.3.4.1 Ọnọdụ chromatographic:
Nnwale nyocha: 1) acetonitrile maka chromatography 2) mmiri dị ọcha 3) phosphoric acid
Ogidi: WondaCract ODS-2 4.6*250mm*5um (8520-39993)
Usoro mkpanaka: A: tụọ nke ọma 1.0ml phosphoric acid na mmiri 1000ml, nyocha ultrasonic degassing.
B: Acetonitrile.
Usoro gradient: tebụl na-esonụ
Oge mkpanaaka usoro A (%) Usoro mkpanaaka B (%)
3 90 10
10 25 75
200100
25 0100
Ihe nchọpụta: 210nm
Okpomọkụ kọlụm: 35 ℃
Ọsọ ọsọ: 1.0ml/min
Nlele nha: 5µl
5.3.4.2 Nkwadebe ngwọta:
5.3.4.3 ihe mgbaze: acetonitrile
5.3.4.4 Ngwọta oghere: a ga-eji diluent mee ihe ngwọta efu.
5.3.4.5 Nnwale ngwaahịa ngwọta: Tulee ngwaahịa ule banyere 12.5mg na karama volumetric 25ml wee gbarie ya na diluent na ọnụ ọgụgụ.
5.3.4.6 Usoro ọrụ: Mgbe ntọala ntọala nke ngwa ahụ kwụsiri ike, a na-emepe injections otu ma ọ bụ abụọ nke ngwọta efu, wee nyochaa ngwọta nke ngwaahịa ule ahụ.A na-echekwa ma nyochaa chromatogram ahụ, a na-ewepụ ọnụ ọgụgụ kasị elu, na isi ịdị ọcha kacha elu na otu adịghị ọcha na chromatogram nke ngwaahịa ule na-edekọ site na usoro nhazi mpaghara.Mgbe nyochachara, a na-ebipụta chromatogram.
Kedu ka esi azụta?Biko kpọtụrụDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Ahụmịhe afọ 15?Anyị nwere ihe karịrị 15 afọ nke ahụmahụ na mmepụta na mbupụ nke a dịgasị iche iche nke elu mma pharmaceutical intermediates ma ọ bụ ezi kemịkal.
Isi ahịa?Na-ere ahịa ụlọ, North America, Europe, India, Korea, Japanese, Australia, wdg.
Uru?Ogo kachasị elu, ọnụ ahịa dị ọnụ ala, ọrụ ọkachamara na nkwado teknụzụ, nnyefe ngwa ngwa.
OgoNkwenye?Usoro njikwa mma siri ike.Ngwá ọrụ ọkachamara maka nyocha gụnyere NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, wdg.
Ihe atụ?Ọtụtụ ngwaahịa na-enye ihe nlele efu maka nyocha dị mma, ndị ahịa kwesịrị ịkwụ ụgwọ mbupu.
Nyocha ụlọ ọrụ?Nnabata nyocha ụlọ ọrụ.Biko mee oge oge tupu oge eruo.
MOQ?Enweghị MOQ.A na-anabata obere usoro.
Oge Mbuga ozi? Ọ bụrụ n'ime ngwaahịa, ekwenyere nnyefe ụbọchị atọ.
Ụgbọ njem?Site Express (FedEx, DHL), nke ikuku, site n'oké osimiri.
Akwụkwọ?Mgbe ọrụ ahịa gasịrị: COA, MOA, ROS, MSDS, wdg nwere ike ịnye.
Synthesis omenala?Nwere ike ịnye ọrụ nhazi ahaziri iche ka ọ dabara mkpa nyocha gị nke ọma.
Usoro ịkwụ ụgwọ?A ga-ebu ụzọ ziga akwụkwọ ọnụahịa Proforma mgbe nkwenye nke iwu, kpuchiri ozi ụlọ akụ anyị.Ịkwụ ụgwọ site na T/T (Telex Nyefee), PayPal, Western Union, wdg.
A na-eji Ethyl Chloro [(4-Methoxyphenyl) hydrazono] acetate (CAS: 27143-07-3) mee ihe dị ka etiti na njikọ nke Apixaban (CAS: 503612-47-3).Apixaban bụ ụdị ọhụụ Xa inhibitor nke Bristol-Myers Squibb na Pfizer mebere.Aha ahia bu Erroto.Ọ bụ ụdị ọgwụ mgbochi ọrịa ọnụ ọhụrụ.Site na igbochi ihe dị mkpa coagulation factor Xa, apixaban nwere ike igbochi mmepụta thrombin na thrombosis.Ụlọ ọrụ Bristal-Myers squibb mepụtara Apixaban.Ọ nwere ezi bioavailability na elu selectivity.Edepụtara ya na China na 2013. Apixaban dị nchebe, ohere nke mmekọrịta ọgwụ ọjọọ dị ntakịrị, na e nwere ọtụtụ ụzọ isi kpochapụ ya, nke a na-atụ anya na a ga-eji ya na ìgwè pụrụ iche na-arịa ọrịa imeju ma ọ bụ mmebi akụrụ.
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