1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-otu CAS 27387-31-1 Ondansetron HCl Dihydrate Intermediate Ọcha>99.0% (HPLC)

1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-otu (CAS: 27387-31-1) ka a na-eji dị ka etiti Ondansetron Hydrochloride Dihydrate (CAS: 103639-04-9).Mmepe ụlọ ọrụ United Kingdom Glaxo, 1990 na France, ahịa United Kingdom.Ngwaahịa ahụ bụ onye na-anabata ihe na-anabata serotonin (5-HT3) nke ukwuu, nwere ike igbochi ọgbụgbọ nke chemotherapy na radiotherapy Vomit, na ike dị elu na nhọrọ dị elu, nwere ike ịchịkwa obere eriri afọ na ndị na-anabata CTZ kpatara site na mkpali nke Vomit.Ọ dị mma maka ọgwụgwọ ọgbụgbọ ọgbụgbọ nke chemotherapy na radiotherapy kpatara, a pụkwara iji ya mee ihe maka mgbochi na ọgwụgwọ nke ọgbụgbọ ọgbụgbọ kpatara mgbe a wachara ya ahụ.

Ondansetron, granisetron na dolasetron bụ ọgwụ antiemetic atọ a na-ejikarị na ụlọ ọgwụ, ondansetron bụ onye na-anabata ihe na-anabata 5-hydroxytryptamine (5-HT3) nke nwere ike, nke na-agbanwe agbanwe maka Alpha 1, Alpha 2, beta 1, Beta 2 adrenergic receptors na histamine H1. h2 receptor nwere obere mmetụta, ọ nweghịkwa mmetụta mmegide na ndị na-anabata H, Central na peripheral dopaminergic receptors, ma nwee ike igbochi ọgbụgbọ na Vomit kpatara chemotherapy na radiotherapy.E jiri ya tụnyere metoclopramide, mmetụta antiemetic siri ike yana enweghị mmeghachi omume extrapyramidal.Cisplatin, cyclophosphamide, doxorubicin nke Vomit kpatara nwere ike ịmepụta mmetụta mgbochi ọgbụgbọ ngwa ngwa na nke siri ike.Kwesịrị ekwesị maka ọgwụgwọ ọgwụ cytotoxic kpatara chemotherapy na ọgwụgwọ radieshon Nausea Vomit, kamakwa mgbochi na ọgwụgwọ nke ọgbụgbọ Vomit kpatara site na ịwa ahụ.ondansetron na-arụ ọrụ dị ka ebe a na-ebufe n'etiti akwara visceral afferent na-arụ ọrụ na tract gastrointestinal na Vomit nke ebe ndị dị na ọkpụkpụ azụ, na-eme ka abdominal na diaphragmatic mmegharị.Ọgwụ chemotherapy na ọgwụgwọ radieshon nwere ike ime ka mwepụta nke 5-HT n'ime obere eriri afọ, na Vomit reflex na-akpata site na mkpali nke akwara vagus site na onye na-anabata 5-HT3.Ngwaahịa a na-egbochi ihe omume nke reflex a, ebe ọ na-egbochi Vomit na-ebute site na mmemme etiti.A maghị usoro ihe omume maka Nausea Vomit mgbe a wachara ya ahụ.Ondansetron jikọtara ya na dexamethasone nwere ike ịkwalite mmetụta antiemetic.