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Ibrutinib Intermediate CAS 330792-70-6 Ịdị Ọcha>98.0% (HPLC) Foto egosipụtara
  • Ibrutinib Intermediate CAS 330792-70-6 Ịdị ọcha>98.0% (HPLC)

Ibrutinib Intermediate CAS 330792-70-6 Ịdị ọcha>98.0% (HPLC)

Nkọwa dị mkpirikpi:

5-Amino-3- (4-Phenoxyphenyl) -1H-Pyrazole-4-Carbonitrile

CAS: 330792-70-6

Dị ọcha:> 98.0% (HPLC)

Ọdịdị: Gbanyụọ-Ọcha ka ntụ ntụ edo edo dị ọkụ

Ọkara nke Ibrutinib (CAS: 936563-96-1) 

Kpọtụrụ: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


Nkọwa ngwaahịa

Ngwaahịa ndị emetụtara

Mkpado ngwaahịa

Ndị etiti nke Ibrutinib:

Ibrutinib CAS 936563-96-1
3-Hydroxypiperidine CAS 6859-99-0
1-Boc-3-Hydroxypiperidine CAS 85275-45-2
(S) -1-Boc-3-Hydroxypiperidine CAS 143900-44-1
4-Phenoxybenzoic acid CAS 2215-77-2
4-Phenoxyphenylboronic Acid CAS 51067-38-0
4-Aminopyrazolo [3,4-d] pyrimidine CAS 2380-63-4
4-Amino-3-Iodo-1H-Pyrazolo[3,4-d] pyrimidine CAS 151266-23-8
Ibrutinib Deacryloylpiperidine CAS 330786-24-8
5-Amino-3- (4-Phenoxyphenyl) -1H-Pyrazole-4-Carbonitrile CAS 330792-70-6

Njirimara kemịkalụ:

Aha Chemical 5-Amino-3- (4-Phenoxyphenyl) -1H-Pyrazole-4-Carbonitrile
Ụdị okwu Ibrutinib Intermediate N-3;3-Amino-5- (4-Phenoxyphenyl) pyrazole-4-Carbonitrile;3-Amino-4-Cyano-5- (4-Phenoxyphenyl) pyrazole;5-Amino-3- (4-Phenoxyphenyl) -1H-Pyrazole-4-Carbonitrile
Nọmba CAS 330792-70-6
Ọnọdụ Ahịa N'ọkwa, Mpụta Ihe ruru Tọn
Usoro ihe omimi C16H12N4O
Ibu molekụla 276.29
Njupụta 1.37±0.10 g/cm3
COA & MSDS Dị
Mmalite Shanghai, China
Ụdị Ruifu Chemical

Nkọwapụta:

Ihe Nkọwapụta
Ọdịdị Gbanyụọ-Ọcha ka ntụ ntụ edo edo dị ọkụ
Ụzọ ịdị ọcha / nyocha > 98.0% (HPLC)
Ọnwụ na ihicha <1.00%
Ihe fọdụrụ na mgbanye <0.50%
Mgbakọta adịghị ọcha <2.00%
Ọla dị arọ (dị ka Pb) <20ppm
1 H NMR Spectrum Nkwekọ na Structure
Nlele ọkọlọtọ Standardkpụrụ ụlọ ọrụ
Ojiji Ọkara nke Ibrutinib (CAS: 936563-96-1)

Ngwungwu & Nchekwa:

ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.

Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri.

Uru:

1

Ajụjụ:

www.ruifuchem.com

330792-70-6 - Ngwa:

5-Amino-3- (4-Phenoxyphenyl) -1H-Pyrazole-4-Carbonitrile (CAS: 330792-70-6) bụ etiti nke Ibrutinib (CAS: 936563-96-1).Ibrutinib na-egosi mmetụta mgbochi na-enweghị ike ịgbagha na nhọrọ maka ọrụ enzymatic Btk.N'ime ahịrị cell DOHH2 na-arụ ọrụ BCR, Ibrutinib na-egbochi autophosphorylation nke Btk, phosphorylation nke Btk's physiological substrate PLCγ, na phosphorylation nke ọzọ downstream kinase, ERK na IC50 nke 11 nM, 29 nM na 13 nM kwa.Ibrutinib na-egosiputa ntinye nke cytotoxicity nke na-adabere na dose na oge na sel lymphocytic leukemia na-adịghị ala ala (CLL).Na mgbakwunye, Ibrutinib na-ebute ọnwụ cell dabere na ịgbalite ụzọ caspase ma na-emegide ikike nke mkpụrụ ndụ CLL ịba ụba mgbe akara TLR gasịrị.

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