CAS 361442-04-8 Ịdị Ọcha>99.0% (HPLC) API

Nkọwa dị mkpirikpi:

Ụdị okwu: BMS-477118;Onglyza

Nọmba: 361442-04-8

Dị ọcha:> 99.0% (HPLC)

Ọdịdị: White ntụ ntụ

API, Ogo dị elu, mmepụta azụmahịa

E-Mail: alvin@ruifuchem.com

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Nkọwa:

Ruifu Chemical Supply Related Intermediates
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Njirimara kemịkalụ:

Ụdị okwu	BMS-477118;Onglyza;(1S,3S,5S) -2- [(2S) -2-Amino-2- (3-Hydroxy-1-Adamantyl) acetyl] -2-Azabicyclo [3.1.0] hexane-3-Carbonitrile;(1S,3S,5S) -2-[(2S) -2-Amino-2- (3-Hydroxytricyclo [3.3.1.13,7] dec-1-yl) acetyl] -2-Azabicyclo[3.1.0] hexane -3-Carbonitrile
Nọmba CAS	361442-04-8
Nọmba CAT	RF-PI1991
Ọnọdụ Ahịa	N'ọkwa, Mpụta Ihe ruru Tọn
Usoro ihe omimi	C18H25N3O2
Ibu molekụla	315.41
Ụdị	Ruifu Chemical

Nkọwapụta:

Ihe	Nkọwapụta
Ọdịdị	Ọcha ntụ ntụ
Isi	Njirimara
njirimara	A: IR B: HPLC Ndokwa Oge
Ụzọ ịdị ọcha / nyocha	> 99.0% (HPLC)
Ịdị ọcha nke ngwọta mmiri	Ntugharị, enweghị agba, ọ nweghị ihe kwụsịtụrụ
Nyocha Sieve	100% gafere 80 Mesh
Ebe Na-agbaze	202.0 ~ 212.0 ℃
Ọnwụ na ihicha	<0.50%
Sulfated Ash	<0.20%
Ntụgharị akọwapụtara	+174.0°~+186.0°
Otu adịghị ọcha	<0.50%
Mgbakọta adịghị ọcha	<1.00%
Ọla dị arọ	<10ppm
Arsenic (dị ka)	<2.0pm
Ndu (Pb)	<1.0pm
Cadmium (Cd)	<1.0pm
Ihe mgbaze fọdụrụnụ	<100ppm
Ihe mgbochi pesticide fọdụrụnụ	Ihe ọjọọ
Microbiology
Ngụkọta ọnụ ọgụgụ efere	<1000cfu/g
Yist & ebu	<100cfu/g
E. Coli	Ihe ọjọọ
S. Aureus	Ihe ọjọọ
Salmonella	Ihe ọjọọ
Ndụ shelf	Ọnwa 24 Site na ụbọchị nrụpụta ma ọ bụrụ na echekwara ya nke ọma
Nlele ọkọlọtọ	Standardkpụrụ ụlọ ọrụ
Ojiji	API;Ọrịa shuga mellitus ụdị 2

Ngwungwu & Nchekwa:

ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ

Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri

Uru:

Ajụjụ:

Ngwa:

(BMS-477118) (CAS: 361442-04-8) bụ onye nwere ike, nhọrọ, ntụgharị, asọmpi na ọnụ na-arụ ọrụ dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM).BMS-477118 nwere peotential maka nchọpụta ọrịa shuga mellitus ụdị 2.BMS-477118bụ ọgwụ ọrịa shuga 2dị nke abụọ nke nwere ike ime ka pancreas mepụta insulin karịa ka o richara nri.E nwetara ya site na nkwado nke AstraZeneca na Bristol-Myers Squibb Company ma bụrụ nke DPP-IV inhibitor.BMS-477118na-arụ ọrụ a site na igbochi mmebi nke GLP-l.GLP-I bụ homonụ a na-emepụta na eriri afọ mgbe ọ risịrị nri.Ọ nwere ike ịhazi mmepụta insulin ma mee ka ojiji nke glucose dị n'ime anụ ahụ dị n'akụkụ.Otu ọgwụ nke BMS-477118 nwere ike melite njikwa glucose ọbara yana ọgwụ jikọtara BMS-477118 na Metformin, Sulfonylurea na Thiazolidinediones nwere ike ịkwalite mmetụta ọgwụgwọ.Ọ na-eduga n'ihe ize ndụ dị ala nke hypoglycemia na mmeghachi omume ọjọọ ya yiri placebo, na-egosi nnabata ka mma.Na Julaị 31, 2009, BMS-477118 Mbadamba ụrọ (Onglyza), ọgwụ ọhụrụ nke ụdị ọrịa shuga 2, nyochakọtara ọnụ wee mepụta AstraZeneca na Bristol-Myers Squibb nke US FDA kwadoro.Enwere ike were ya otu ugboro n'ụbọchị iji gwọọ ụdị ọrịa shuga 2 yana njikwa nri na mmega ahụ.