5- (2-Pyridyl) -1,2-Dihydropyridin-2-otu CAS 381233-78-9 Perampanel Intermediate Purity>98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. bụ onye na-emepụta ihe nke 5- (2-Pyridyl) -1,2-Dihydropyridin-2-otu ([2,3'-Bipyridin] -6'(1'H) -otu. (CAS: 381233-78-9) na oke mma, etiti Perampanel (CAS: 380917-97-5).Ruifu Chemical nwere ike ịnye nnyefe zuru ụwa ọnụ, ọnụahịa asọmpi, ọrụ magburu onwe ya, obere na nnukwu ọnụọgụ dị.Ịzụta ndị etiti Perampanel,Please contact: alvin@ruifuchem.com
| Aha Chemical | 5- (2-Pyridyl) -1,2-Dihydropyridin-2-otu |
| Ụdị okwu | [2,3'-Bipyridin] -6'(1'H) -otu;5-(Pyridin-2-yl) pyridin-2 (1H) -otu;5-(Pyridin-2-yl)-2 (1H) -Pyridone;5- (2-Pyridyl) pyridin-2 (1H) -otu;5-Pyridin-2-yl-1H-Pyridin-2-otu;5-(Pyridin-2-yl) -1,2-Dihydropyridin-2-otu;Perampanel adịghị ọcha 1 |
| Ọnọdụ Ahịa | Na ngwaahịa, Mmepụta Azụmahịa |
| Nọmba CAS | 381233-78-9 |
| Usoro ihe omimi | C10H8N2O |
| Ibu molekụla | 172.18 g/mol |
| Ebe Na-agbaze | 71.0 ~ 75.0 ℃ |
| Njupụta | 1.221±0.06 g/cm3 |
| COA & MSDS | Dị |
| Mmalite | Shanghai, China |
| Otu | Ọkara nke Perampanel (CAS: 380917-97-5) |
| Ndụ shelf | Ọnwa 24 ma ọ bụrụ na echekwara ya nke ọma |
| Ụdị | Ruifu Chemical |
| Ihe | Ụkpụrụ nyocha | Nsonaazụ |
| Ọdịdị | Ọcha ka ọ fọrọ nke nta ka ọ bụrụ ọcha ntụ ntụ | Ọcha ntụ ntụ |
| Ụzọ ịdị ọcha / nyocha | > 98.0% (HPLC) | 99.7% |
| Mmiri nke Karl Fischer | <1.00% | 0.58% |
| Otu adịghị ọcha | <1.00% | Na-akwado |
| Mgbakọta adịghị ọcha | <2.00% | 0.30% |
| 1H NMR Spectrum | Nkwekọ na Structure | Na-akwado |
| Mmechi | A nwalela ngwaahịa a wee kwado nkọwa ndị enyere | |
| Ngwa | Ọkara nke Perampanel (CAS: 380917-97-5) | |
ngwugwu:Fluorinated Bottle, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Debe akpa ahụ nke ọma ma debe ya n'ụlọ nkwakọba ihe dị jụụ, kpọrọ nkụ na nke ikuku na-ekpo ọkụ n'ebe ihe na-adabaghị adaba.Chebe site na ìhè na mmiri mmiri.
Mbupu:Jiri ikuku na-ebuga ụwa niile site na FedEx / DHL Express.Nye nnyefe ngwa ngwa na ntụkwasị obi.
Njirimara: Ọcha ka ọ fọrọ nke nta ka ọ bụrụ ntụ ntụ
Ihe mgbaze: Tetrahydrofuran, Toluene, Ethylacetate, Ethanol, Methanol, tert-Butyl Methyl Ether, Petroleum Ether, n-Hexane, Dichloromethane
Lelee: Ihe ndị emetụtara: Were ngwaahịa a wee jiri ihe na-esi ísì ụtọ mee ya (mmiri na-agagharị agagharị: methanol (50∶50)) iji mee ngwọta nwere ihe dị ka 0.5mg kwa 1ml dị ka ngwọta ngwaahịa ule.Dabere na chromatography mmiri mmiri dị elu (Chinese Pharmacopoeia 2010 Edition II Appendix Ⅴ D), a na-eji silica gel (ZORBAX SB-C18 4.6 × 250mm,5m) mee ihe dị ka ihe ndochi.Usoro mkpanaaka A bụ mmiri, usoro mkpanaaka B bụ methanol, na ogologo ogologo nchọta bụ 254nm.Ọnụego ya bụ 1.0ml/min yana okpomoku kọlụm bụ ụlọ okpomọkụ.A tụrụ 5μl nke ngwọta nnwale nke ọma wee tinye ya n'ime chromatograph mmiri mmiri iji dekọọ chromatogram.Dabere na usoro nhazi mpaghara, ọdịnaya nke ngwaahịa a abụghị ihe na-erughị 98%.Ọ bụrụ na enwere oke adịghị ọcha na chromatogram nke ngwọta ngwaahịa nnwale, mpaghara adịghị ọcha nke onye ọ bụla agaghị agafe 1.0%, na nchikota nke ebe adịghị ọcha agaghị agafe 2.0%.
Mmiri: Were ngwaahịa a, jiri ihe nyocha mmiri, dị ka usoro Karl Fischer si dị (Chinese Pharmacopoeia 2010 mbipụta II Appendix Ⅷ M ụzọ mbụ A) mkpebi siri ike, ọdịnaya mmiri agaghị agafe 1.0%.
Kedu ka esi azụta?Biko kpọtụrụDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Ahụmịhe afọ 15?Anyị nwere ihe karịrị 15 afọ nke ahụmahụ na mmepụta na mbupụ nke a dịgasị iche iche nke elu mma pharmaceutical intermediates ma ọ bụ ezi kemịkal.
Isi ahịa?Na-ere ahịa ụlọ, North America, Europe, India, Korea, Japanese, Australia, wdg.
Uru?Ogo kachasị elu, ọnụ ahịa dị ọnụ ala, ọrụ ọkachamara na nkwado teknụzụ, nnyefe ngwa ngwa.
OgoNkwenye?Usoro njikwa mma siri ike.Ngwá ọrụ ọkachamara maka nyocha gụnyere NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, wdg.
Ihe atụ?Ọtụtụ ngwaahịa na-enye ihe nlele efu maka nyocha dị mma, ndị ahịa kwesịrị ịkwụ ụgwọ mbupu.
Nyocha ụlọ ọrụ?Nnabata nyocha ụlọ ọrụ.Biko mee oge oge tupu oge eruo.
MOQ?Enweghị MOQ.A na-anabata obere usoro.
Oge Mbuga ozi? Ọ bụrụ n'ime ngwaahịa, ekwenyere nnyefe ụbọchị atọ.
Ụgbọ njem?Site Express (FedEx, DHL), nke ikuku, site n'oké osimiri.
Akwụkwọ?Mgbe ọrụ ahịa gasịrị: COA, MOA, ROS, MSDS, wdg nwere ike ịnye.
Synthesis omenala?Nwere ike ịnye ọrụ nhazi ahaziri iche ka ọ dabara mkpa nyocha gị nke ọma.
Usoro ịkwụ ụgwọ?A ga-ebu ụzọ ziga akwụkwọ ọnụahịa Proforma mgbe nkwenye nke iwu, kpuchiri ozi ụlọ akụ anyị.Ịkwụ ụgwọ site na T/T (Telex Nyefee), PayPal, Western Union, wdg.
5- (2-Pyridyl) -1,2-Dihydropyridin-2-otu ([2,3'-Bipyridin] -6'(1'H) -otu (CAS: 381233-78-9), nke etiti nke Perampanel (CAS: 380917-97-5).Perampanel (nke enyere ikike na 2012) bụ ọgbọ nke atọ AED mara aha njirimara nke Fycompa® (Eisai, Hatfield) na UK yana Banzel® (Eisai, Hatfield) na USA.Ngwọta mgbakwunye nke ọdịdọ mgbadoro anya na-enwe ma ọ bụ na-enweghị nchikota nke abụọ yana ọdịdọ tonic-clonic n'ozuzu ya.N'October 2012, US FDA kwadoro perampanel maka ọgwụgwọ nke obere mmalite mmalite na ndị ọrịa akwụkwụ bụ ndị dịkarịa ala afọ 12.Perampanel bụ onye na-anabata AMPA mbụ na-anata nkwado FDA dị ka AED.A na-ahụ ndị na-anabata AMPA glutamate nke ọma na neurons postsynaptik na ụbụrụ.Dị ka onye na-ahọrọ, onye mmegide na-enweghị asọmpi nke AMPA, parampanel na-egbochi imeghe ọwa ion ma belata mgbasa nke ike omume.
