Apixaban Intermediate CAS 503615-03-0 3-Morpholino-1- (4-Nitrophenyl) -5,6-Dihydropyridin-2 (1H) -otu ịdị ọcha ≥99.0% (HPLC)
Ruifu Chemical bụ onye na-emepụta ihe na-emepụta 3-Morpholino-1- (4-Nitrophenyl) -5,6-Dihydropyridin-2 (1H) -otu (CAS: 503615-03-0) na elu mma.Ruifu Chemical nwere ike ịnye nnyefe zuru ụwa ọnụ, ọnụahịa asọmpi, ọrụ magburu onwe ya, obere na nnukwu ọnụọgụ dị.Ịzụta ndị etiti Apixaban,Please contact: alvin@ruifuchem.com
| Aha Chemical | 3-Morpholino-1- (4-Nitrophenyl) -5,6-Dihydropyridin-2 (1H) - otu. |
| Ụdị okwu | 3- (4-Morpholinyl) -1- (4-Nitrophenyl) -5,6-Dihydro-2 (1H) -Pyridinone;5,6-Dihydro-3- (4-Morpholinyl) -1- (4-Nitrophenyl) -2 (1H) -Pyridinone;Apixaban Intermediate 3;Apixaban adịghị ọcha 36;Usoro Apixaban adịghị ọcha 1 |
| Ọnọdụ Ahịa | Na ngwaahịa, Mmepụta Azụmahịa |
| Nọmba CAS | 503615-03-0 |
| Usoro ihe omimi | C15H17N3O4 |
| Ibu molekụla | 303.31 g/mol |
| Ebe Na-agbaze | 165.0 ~ 170.0 ℃ |
| Ebe esi nri | 506.5± 50.0 ℃ |
| Njupụta | 1.357g/mL |
| COA & MSDS | Dị |
| Mmalite | Shanghai, China |
| Otu | Ọkara nke Apixaban (CAS: 503612-47-3) |
| Ụdị | Ruifu Chemical |
| Ihe | Ụkpụrụ nyocha | Nsonaazụ |
| Ọdịdị | Ntụ ntụ odo | Ntụ ntụ odo |
| Ebe Na-agbaze | 165.0 ~ 170.0 ℃ | 167.0 ~ 170.0 ℃ |
| Ọnwụ na ihicha | ≤0.50% | 0.3% |
| Ọdịghị ọcha nke Onwe Onye (Max.) | ≤0.50% | 0.3% |
| Mgbakọta adịghị ọcha | ≤1.00% | 0.6% |
| Ụzọ ịdị ọcha / nyocha | ≥99.0% (HPLC) | 99.4% |
| 1 H NMR Spectrum | Nkwekọ na Structure | Na-akwado |
| LC/MS | Nkwekọ na Structure | Na-akwado |
| Mmechi | A nwalela ngwaahịa a wee kwado nkọwa ndị enyere | |
ngwugwu:Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
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Isi ahịa?Na-ere ahịa ụlọ, North America, Europe, India, Korea, Japanese, Australia, wdg.
Uru?Ogo kachasị elu, ọnụ ahịa dị ọnụ ala, ọrụ ọkachamara na nkwado teknụzụ, nnyefe ngwa ngwa.
OgoNkwenye?Usoro njikwa mma siri ike.Ngwá ọrụ ọkachamara maka nyocha gụnyere NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, wdg.
Ihe atụ?Ọtụtụ ngwaahịa na-enye ihe nlele efu maka nyocha dị mma, ndị ahịa kwesịrị ịkwụ ụgwọ mbupu.
Nyocha ụlọ ọrụ?Nnabata nyocha ụlọ ọrụ.Biko mee oge oge tupu oge eruo.
MOQ?Enweghị MOQ.A na-anabata obere usoro.
Oge Mbuga ozi? Ọ bụrụ n'ime ngwaahịa, ekwenyere nnyefe ụbọchị atọ.
Ụgbọ njem?Site Express (FedEx, DHL), nke ikuku, site n'oké osimiri.
Akwụkwọ?Mgbe ọrụ ahịa gasịrị: COA, MOA, ROS, MSDS, wdg nwere ike ịnye.
Synthesis omenala?Nwere ike ịnye ọrụ nhazi ahaziri iche ka ọ dabara mkpa nyocha gị nke ọma.
Usoro ịkwụ ụgwọ?A ga-ebu ụzọ ziga akwụkwọ ọnụahịa Proforma mgbe nkwenye nke iwu, kpuchiri ozi ụlọ akụ anyị.Ịkwụ ụgwọ site na T/T (Telex Nyefee), PayPal, Western Union, wdg.
3-Morpholino-1- (4-Nitrophenyl) -5,6-Dihydropyridin-2 (1H) -otu (CAS: 503615-03-0) bụ etiti maka njikọ nke Apixaban (CAS: 503612-47-3) .
Apixaban bụ ụdị ọhụrụ nke inhibitor Xa factor inhibitor nke Bristol-Myers Squibb na Pfizer mebere.Aha ahia a bu Eratol, nke bu udi ohuru nke anticoagulant nke onu.Site na igbochi ihe dị mkpa coagulation Xa, Apixaban nwere ike igbochi mmepụta thrombin na thrombosis.
N'April 26, 2007, Bristol-Myers Squibb sonyeere Pfizer aka ikwusa nkwado na mmepe nke ọhụrụ anticoagulant Apixaban nke Bristol-Myers Squibb nwere dị ka ihe nkwalite ọzọ na warfarin.Dị ka nkwekọrịta imekọ ihe ọnụ, Pfizer ga-akwụ ụgwọ tupu ugwo nke US $ 0.25 ijeri na Bristol-Myers Squibb iji buru 60% nke mkpokọta mmepe nke anticoagulant Apixaban (a ga-emejuputa ya site na Jenụwarị 1, 2007), ebe Bristol-Myers. Squibb ga-ebu 40% fọdụrụnụ, si otú a na-enweta ikike ijikọ mmepụta na ire ọgwụ ahụ.
Na May 2011, Apixaban bụ onye mbụ kwadoro mgbochi nke thrombosis venous na ndị ọrịa toro eto na-ahọrọ ịwa ahụ hip ma ọ bụ ikpere na mba 27 EU, Iceland na Norway.
Na Nọvemba 20, 2012, European Commission kwadoro Ererto (Apixaban) maka igbochi ọrịa strok na usoro embolism na ndị okenye na-arịa ọrịa na-adịghị valvular atrial fibrillation (NVAF) na otu ma ọ bụ karịa ihe ize ndụ.N'ikpeazụ, Canadian Food and Drug Administration, Japan, na US FDA kwadoro Ererto (Apixaban) maka mgbochi nke ọrịa strok na embolism systemic na ndị ọrịa toro eto na-enweghị valvular atrial fibrillation (NVAF) nwere otu ma ọ bụ karịa ihe ize ndụ.
N'April 12, 2013, a mara ọkwa ọkwa ọgwụ ọhụrụ anticoagulant Eloto (ELIQUIS)(apixaban) nke Bristol-Myers Squibb na Pfizer mebere na China.Ererto bụ ihe na-egbochi ọnụ Xa inhibitor maka mgbochi nke venous thromboembolism (VTE) n'ime ndị ọrịa toro eto na-anata ngbanwe hip ma ọ bụ ikpere.Ndepụta ya na-enye nhọrọ ọhụrụ dị mma ma dị irè maka ọgwụ mgbochi ọrịa ọgwụ mgbe a wachara ahụ ọkpụkpụ, ma na-ewetara ndị ọrịa China na-eme mgbanwe mgbanwe hip / ikpere.Nnyocha ụlọ ọgwụ ekwenyela na e jiri ya tụnyere 40mg enoxaparin otu ugboro n'ụbọchị, nchịkwa ọnụ nke Eratol (Apixaban) 2.5mg ugboro abụọ n'ụbọchị dị irè karị maka igbochi thromboembolism venous mgbe ịwa ahụ dochie hip ma ọ bụ ikpere, na ọ dịghị eme ka ohere nke ọbara ọgbụgba dịkwuo elu.
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