TMC207 CAS 843663-66-1 Ịdị Ọcha>99.5% (HPLC)
| Aha Chemical | TMC207 |
| Ụdị okwu | TMC-207, R207910;Sirturo;(αS, βR) -6-Bromo-α-[2- (dimethylamino) ethyl] -2-methoxy-α-1-naphthalenyl-β-phenyl-3-Quinolineethanol;1- (6-Bromo-2-methoxyquinolin-3-yl) -4-dimethylamino-1-phenyl-2- (1-naphthyl) 2-butanol. |
| Nọmba CAS | 843663-66-1 |
| Nọmba CAT | RF2336 |
| Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
| Usoro ihe omimi | C32H31BrN2O2 |
| Ibu molekụla | 555.516 |
| Ebe Na-agbaze | 104 ℃ |
| Njupụta | 1.322±0.06 g/cm3 |
| Mmetụta | Hygroscopic.Ìhè nwere mmetụta, mmetụta ikuku |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta |
| Ọdịdị | Ọcha ma ọ bụ Gbanyụọ-Ọcha ntụ ntụ |
| Ụzọ ịdị ọcha / nyocha | > 99.5% (HPLC) |
| Ọnwụ na ihicha | <0.50% |
| Ihe fọdụrụ na mgbanye | <0.20% |
| Ọdịghị ọcha nke Onye ọ bụla | <0.10% |
| Isomer | <0.10% |
| Mgbakọta adịghị ọcha | <0.50% |
| Ọla dị arọ (dị ka Pb) | <20ppm |
| Arsenic (dị ka) | <2.0pm |
| Spectrum infrared | Dabara na Ọdịdị |
| Ọnụ ego nke Proton NMR Spectrum | Dabara na Ọdịdị |
| Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
| Ojiji | API |
ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri
Kedu ka esi azụta?Please contact: sales@ruifuchem.com or alvin@ruifuchem.com
Ahụmịhe afọ 15?Anyị nwere ihe karịrị 15 afọ nke ahụmahụ na mmepụta na mbupụ nke a dịgasị iche iche nke elu mma pharmaceutical intermediates ma ọ bụ ezi kemịkal.
Isi ahịa?A na-ebupụ ya na North America, India, Russia, Korea, Japanese, na Europe, wdg.
OgoNkwenye?Nkwenye ntụkwasị obi dị mma, njikwa siri ike.Ngwá ọrụ ọkachamara maka nyocha gụnyere NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, wdg.
Ihe atụ?Ọtụtụ ngwaahịa na-enye ihe nlele efu maka nyocha dị mma, ndị ahịa kwesịrị ịkwụ ụgwọ mbupu.
Nyocha ụlọ ọrụ?Nnabata nyocha ụlọ ọrụ.Biko mee oge oge tupu oge eruo.
MOQ?Enweghị MOQ.A na-anabata obere usoro.
Oge Mbuga ozi? Ọ bụrụ n'ime ngwaahịa, ekwenyere nnyefe ụbọchị atọ.
Ụgbọ njem?Site Express (FedEx, DHL), nke ikuku, n'oké osimiri.
Synthesis omenala?Nwere ike ịnye ọrụ nhazi nhazi.
Usoro ịkwụ ụgwọ?A ga-ebu ụzọ ziga akwụkwọ ọnụahịa Proforma mgbe nkwenye nke iwu, kpuchiri ozi ụlọ akụ anyị.Ịkwụ ụgwọ site na T/T (Telex Nyefee), PayPal, Western Union, wdg.
(CAS: 843663-66-1), (nke a maara dị ka TMC207 na R207910), na-ere ahịa n'okpuru aha ahia Sirturo, bụ akwụkwọ akụkọ diarylquinoline antimycobacterial ọgwụ na-emetụta ụkwara nta site na igbochi ọrụ nke M. tuberculosis ATP synthase proton pump.Njikọ ATP nke mycobacteria na-arụ ọrụ antibacterial na bactericidal.A na-eji ụlọ ọgwụ na-agwọ ụkwara nta na-eguzogide ọgwụ ndị okenye (MDR-PTB).TMC207 nwere otu nje bacteria na-arụ megide M. ụkwara nta na-enwe mmetụta dị nro na nke na-eguzogide ọgwụ, ma na-enwekwa mmetụta dị mma sterilization na nje bacteria na-ehi ụra.Na Disemba 2012, US FDA kwadoro TMC207 dị ka akụkụ nke ọgwụgwọ ngwakọta maka ọgwụgwọ ụkwara nta na-eguzogide ọgwụ (MDRTB).TMC207 bụ ọgwụ izizi akwadoro maka MDR-TB ma bụrụ nnabata izizi sitere na klaasị ọhụrụ nke ọgwụ mgbochi ụkwara nta n'ime afọ 40 gara aga.N'ihi mkpa ahụike dị elu maka ịgwọ MDR-TB, FDA nyere TMC207 nkwado ngwa ngwa dabere na nsonaazụ nke II, na-enye ndị ọrịa ohere ịnweta ọgwụ ahụ ebe a na-eme nyocha ụlọ ọgwụ ọzọ.TMC207 bụ diarylquinoline nke achọpụtara site na usoro nyocha dị elu, nke na-enyocha mkpụrụ ndụ niile na Mycobacterium smegmatis ejiri mee ihe maka ọrịa ụkwara nta M.TMC207 bụ otu ihe na-eme ka ihe nyocha mbụ pụta.TMC207 nwere ike na nhọrọ ọrụ megide mycobacteria, ma na-arụsi ọrụ ike megide ma ọgwụ-enwe mmetụta na ọgwụ na-eguzogide ọgwụ M. ụkwara nta.Usoro omume nke TMC207 bụ ihe pụrụ iche n'etiti ọgwụ mgbochi TB na gụnyere mgbochi nke mycobacterial ATP synthase;Ọ naghị arụ ọrụ megide ATP synthase mmadụ.TMC207 nwere ọrụ vivo n'ọtụtụ ụdị ọrịa TB, naanị yana yana yana ndị ọrụ mgbochi TB ndị ọzọ, ma nwee ọrụ nje na ụdị ọrịa TB guzobere.A na-ahazi TMC207 na nzọụkwụ ise site na 3-Phenylpropionic Acid na para-Bromoaniline.Na-eso nhazi amide, ọgwụgwọ na POCl3 na DMF n'okpuru ọnọdụ Vilsmeier-Hack nyere ngwaahịa 2-Chloroquinoline.Ọgwụgwọ na sodium methoxide, sochiri condensation na 3- (Dimethylamino) -1- (naphthalen-1-yl) propan-1-one, na nkewa nke isomers nyere TMC207.
