Trelagliptin Succinate Intermediate CAS 865759-24-6 Ịdị Ọcha>98.0% (HPLC)

2- ((6-chloro-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1 (2H)-yl) Methyl) -4-fluorobenzonitrile (CAS: 865759-24-6) ka eji etiti nke Trelagliptin Succinate (CAS: 1029877-94-8).Trelagliptin Succinate, nke Takeda, Japan mepụtara, nke ewepụtara na Machị 2015, n'okpuru aha azụmaahịa Zafatek, na-eji agwọ ụdị ọrịa shuga 2.Trelagliptin bụ ihe mgbochi dipeptidyl peptidase IV (DPP-4) na-eme ogologo oge site na nhọrọ na-aga n'ihu na-egbochi DPP-4 iji chịkwaa ọkwa shuga dị n'ọbara.Trelagliptin bụ ọgwụ hypoglycemic nke mbụ kwa izu n'ahịa, yana ndị na-egbochi DPP-4 dị n'ahịa kwesịrị ị were otu ugboro n'ụbọchị.Ihe ịrụ ụka adịghị ya na uru ọgwụ Zafatek ga-enye nhọrọ ọgwụgwọ dabara adaba maka ndị ọrịa nwere ọrịa shuga.A na-atụ anya na ọ ga-eme ka ọ dị mma na nnabata nke ndị ọrịa.Na Machị 26, 2015, Giant Japan na-emepụta ọgwụ Takeda kwupụtara na Ministri ahụike, ọrụ na ọdịmma Japan (MHLW) kwadoro ọgwụ ọrịa shuga ọhụrụ Zafatek maka ọgwụgwọ ụdị ọrịa shuga 2.Nkwenye ahụ gosipụtara Zafatek ka ọ bụrụ ọgwụ mbụ hypoglycemic ọnụ kwa izu n'ahịa n'ụwa, ma na-anọchi anya ngọngọ nke Takeda tụbara n'ahịa ọrịa shuga.
Trelagliptin bụ onye na-egbochi dipeptidyl peptidase IV (DPP-4) otu ugboro kwa izu nke na-achịkwa ọkwa shuga dị n'ọbara site na nhọrọ na-aga n'ihu na-egbochi DPP-4.DPP-4 bụ enzyme nke nwere ike ịmalite incretin (glucagon-like peptide-1 (GLP-1) na insulinotropic polypeptide na-adabere na glucose (GIP), nke na-arụ ọrụ dị mkpa na nhazi ọkwa glucose ọbara.Mgbochi nke DPP-4 nwere ike ime ka insulin na-adabere na ọkwa shuga dị n'ọbara, si otú a na-achịkwa ọkwa shuga dị n'ọbara.Nrubeisi Trelagliptin NDA dabere na ịdị irè na data nchekwa sitere na ọtụtụ nnwale ụlọ ọgwụ nke a na-eme na ndị ọrịa Japan nwere ụdị ọrịa shuga 2.Ekwenyere ịdị irè nke Trelagliptin n'ime ule niile, yana ọ nwere ezigbo nchekwa na nnabata.Nlekọta Trelagliptin otu ugboro n'izu nwere ike ijikwa ọkwa shuga dị n'ọbara nke ọma ma na-atụ anya ịkwalite nnabata ọgwụ ndị ọrịa.