Crizotinib Intermediate CAS 877399-00-3 ịdị ọcha ≥98.0% (HPLC) ee ≥99.0%
Shanghai Ruifu Chemical Co., Ltd. bụ onye na-emepụta ihe (R) -5-Bromo-3-[1- (2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine (CAS: 877399-00) -3) na oke mma, etiti nke Crizotinib (CAS: 877399-52-5).Ruifu Chemical nwere ike ịnye nnyefe zuru ụwa ọnụ, ọnụahịa asọmpi, ọrụ magburu onwe ya, obere na nnukwu ọnụọgụ dị.Ịzụta Crizotinib Intermediate,Please contact: alvin@ruifuchem.com
| Aha Chemical | (R) -5-Bromo-3-[1- (2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine |
| Ụdị okwu | Crizotinib Intermediate;Crizotinib Bromide adịghị ọcha;5-Bromo-3-[(1R) -1- (2,6-Dichloro-3-Fluorophenyl) ethoxy] -2-Pyridinamine;[5-Bromo-3-[(1R)-(2,6-Dichloro-3-Fluorophenyl)ethoxy] pyridin-2-yl] amine |
| Ọnọdụ Ahịa | Na ngwaahịa, Mmepụta Azụmahịa |
| Nọmba CAS | 877399-00-3 |
| Usoro ihe omimi | C13H10BrCl2FN2O |
| Ibu molekụla | 380.04 g/mol |
| Ebe Na-agbaze | 108.0 ruo 113.0 ℃ |
| Njupụta | 1.643 |
| COA & MSDS | Dị |
| Ihe atụ | Dị |
| Mmalite | Shanghai, China |
| Otu | Ọkara nke Crizotinib (CAS: 877399-52-5) |
| Ụdị | Ruifu Chemical |
| Ihe | Ụkpụrụ nyocha | Nsonaazụ |
| Ọdịdị | Icha edo edo ka ọ bụrụ ntụ ntụ na kristal | Na-akwado |
| Ebe Na-agbaze | 108.0 ruo 113.0 ℃ | Na-akwado |
| Ọcha (Mpaghara HPLC) | ≥98.0% | 99.1% |
| Enantiomeric ngafe (EE) | ≥99.0% | 99.5% |
| Spectrum infrared | Dabara na Ọdịdị | Na-akwado |
| 1 H NMR Spectrum | Dabara na Ọdịdị | Na-akwado |
| Mmechi | A nwalela ngwaahịa a & na-akwado nkọwapụta | |
| Ndụ shelf | Afọ 2 ma ọ bụrụ na echekwara ya nke ọma | |
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Kedu ka esi azụta?Biko kpọtụrụDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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MOQ?Enweghị MOQ.A na-anabata obere usoro.
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Synthesis omenala?Nwere ike ịnye ọrụ nhazi ahaziri iche ka ọ dabara mkpa nyocha gị nke ọma.
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(R) -5-Bromo-3-[1- (2,6-Dichloro-3-Fluorophenyl)ethoxy] pyridin-2-Amine (CAS: 877399-00-3) na-eji dị ka etiti nke Crizotinib (CAS: 877399-52-5).
Crizotinib bụ n'ezie ọgwụ mgbochi ọrịa cancer na-aghọ alk (anaplastic lymphoma kinase) na ros1 (c-ros oncogene 1) inhibitor, kwadoro maka ọgwụgwọ nke ụfọdụ carcinoma na-abụghị obere cell lung (NSCLC) na usa na ụfọdụ mba ndị ọzọ, na na-aga n'ọtụtụ ọmụmụ na-anwale nchekwa ya na ịdị irè ya na lymphoma nnukwu cell anaplastic, neuroblastoma, na etuto siri ike ndị ọzọ dị elu na ndị okenye na ụmụaka.
Crizotinib bụ ọgwụ ezubere iche maka ọgwụgwọ ọrịa kansa akpa ume na-abụghị obere cell nke Pfizer, USA mepụtara, secorri bụ oke ala na ọgwụ na-eme oge na ngalaba ọgwụgwọ ezubere iche maka ọrịa kansa akpa ume.A kwadoro ya maka ịre ahịa na United States na August 2011 wee dee ya na ntụziaka ọgwụgwọ ọrịa cancer akpa ume mba ụwa na njedebe nke afọ dị ka ọgwụ mbụ maka ndị ọrịa ALK.Ejikọtara ya na Crizotinib bụ usoro nchọpụta mkpụrụ ndụ nke mbụ na-eji fluorescence in situ hybridization (FISH) -VSIs ALK Break Apart FISH Probe Kit, nke a bụ usoro a na-eji ugbu a na ule ụlọ ọgwụ zuru ụwa ọnụ iji chọpụta EML4-ALK fusion genes na NSCLC.Nnwale a ga-enyere aka chọpụta ndị ọrịa nwere ike irite uru na ọgwụgwọ Crizotinib.
Crizotinib bụ onye na-emechi ihe na-anabata tyrosine kinase nke a na-eji na ọgwụgwọ nke ahọpụtara nke ọrịa cancer akpa ume na-abụghị obere cell.Ọ bụ okpukpu abụọ ATP asọmpi inhibitor nke tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50 = 8 nM) na ALK (cellular IC50 = 20 nM), nke abụọ bụ ebumnuche dị mkpa maka chemotherapy cancer.Mgbe a nwalere Crizotinib maka selectivity megide ndị ọzọ kinases, a chọpụtara na ọ nwere enzyme IC50's n'ime 100-fold multiples nke c-MET maka 13 nke 120 kinases nwalere.Na nyocha ekwentị, ahụrụ Crizotinib ka ọ na-egbochi RON (recepteur d'origine nantais) kinase na windo nhọrọ nke ugboro iri n'elu c-MET.N'ozuzu, onye ọrụ a na-egbochi uto cell tumor.XALKORI®(Crizotinib) bụ ọgwụ ndenye ọgwụ na-eji agwọ ndị nwere ọrịa kansa akpa ume na-abụghị obere cell (NSCLC) nke gbasaara n'akụkụ ahụ ndị ọzọ ma kpatara ntụpọ dị na mkpụrụ ndụ ihe nketa akpọrọ ALK (anaplastic lymphoma kinase) ma ọ bụ mkpụrụ ndụ ihe nketa akpọrọ ROS1.A maghị ma XALKORI dị mma ma dị irè na ụmụaka.
