1- (1-Boc-4-Piperidinyl) -4-Iodopyrazole CAS 877399-73-0 Ịdị ọcha ≥99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. bụ onye na-emepụta ihe nke 1- (1-Boc-4-Piperidinyl) -4-Iodopyrazole (CAS: 877399-73-0) nwere àgwà dị elu, etiti nke Crizotinib (CAS: 877399-52). -5).Ruifu Chemical nwere ike ịnye nnyefe zuru ụwa ọnụ, ọnụahịa asọmpi, ọrụ magburu onwe ya, obere na nnukwu ọnụọgụ dị.Ịzụta Crizotinib Intermediates,Please contact: alvin@ruifuchem.com
| Aha Chemical | 1- (1-Boc-4-Piperidinyl) -4-Iodopyrazole |
| Ụdị okwu | 1-Boc-4- (4-Iodo-1H-Pyrazol-1-yl) piperidine;tert-Butyl 4- (4-Iodo-1H-Pyrazol-1-yl) piperidine-1-Carboxylate;tert-Butyl 4- (4-Iodopyrazolyl) piperidinecarboxylate;Crizotinib adịghị ọcha 16 |
| Ọnọdụ Ahịa | Na ngwaahịa, Mmepụta Azụmahịa |
| Nọmba CAS | 877399-73-0 |
| Usoro ihe omimi | C13H20IN3O2 |
| Ibu molekụla | 377.22 g/mol |
| Ebe Na-agbaze | 97 ℃ |
| Njupụta | 1.60±0.10 g/cm3 |
| Mmetụta | Ìhè nwere mmetụta |
| Okpomọkụ nchekwa. | 2 ~ 8 ℃, Chebe site na ìhè |
| COA & MSDS | Dị |
| Mmalite | Shanghai, China |
| Otu | Ọkara nke Crizotinib (CAS: 877399-52-5) |
| Ụdị | Ruifu Chemical |
| Ihe | Ụkpụrụ nyocha | Nsonaazụ |
| Ọdịdị | Ọcha na-acha odo odo siri ike | Ọcha siri ike |
| Ụzọ ịdị ọcha / nyocha | ≥99.0% (HPLC) | 99.58% |
| Spectrum infrared | Dabara na Ọdịdị | Na-akwado |
| 1 H NMR Spectrum | Dabara na Ọdịdị | Na-akwado |
| ESI+ | Dabara | Na-akwado |
| Mmechi | A nwalela ngwaahịa a wee kwado nkọwa ndị enyere | |
ngwugwu:Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Debe akpa ahụ nke ọma ma chekwaa n'ebe dị jụụ, kpọrọ nkụ (2 ~ 8 ℃) yana ụlọ nkwakọba ihe nke ọma na-esi na ihe ndị na-adabaghị adaba.Chebe site na ìhè na mmiri mmiri.
Mbupu:Jiri ikuku na-ebuga ụwa niile site na FedEx / DHL Express.Nye nnyefe ngwa ngwa na ntụkwasị obi.
Kedu ka esi azụta?Biko kpọtụrụDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Ahụmịhe afọ 15?Anyị nwere ihe karịrị 15 afọ nke ahụmahụ na mmepụta na mbupụ nke a dịgasị iche iche nke elu mma pharmaceutical intermediates ma ọ bụ ezi kemịkal.
Isi ahịa?Na-ere ahịa ụlọ, North America, Europe, India, Korea, Japanese, Australia, wdg.
Uru?Ogo kachasị elu, ọnụ ahịa dị ọnụ ala, ọrụ ọkachamara na nkwado teknụzụ, nnyefe ngwa ngwa.
OgoNkwenye?Usoro njikwa mma siri ike.Ngwá ọrụ ọkachamara maka nyocha gụnyere NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, wdg.
Ihe atụ?Ọtụtụ ngwaahịa na-enye ihe nlele efu maka nyocha dị mma, ndị ahịa kwesịrị ịkwụ ụgwọ mbupu.
Nyocha ụlọ ọrụ?Nnabata nyocha ụlọ ọrụ.Biko mee oge oge tupu oge eruo.
MOQ?Enweghị MOQ.A na-anabata obere usoro.
Oge Mbuga ozi? Ọ bụrụ n'ime ngwaahịa, ekwenyere nnyefe ụbọchị atọ.
Ụgbọ njem?Site Express (FedEx, DHL), nke ikuku, site n'oké osimiri.
Akwụkwọ?Mgbe ọrụ ahịa gasịrị: COA, MOA, ROS, MSDS, wdg nwere ike ịnye.
Synthesis omenala?Nwere ike ịnye ọrụ nhazi ahaziri iche ka ọ dabara mkpa nyocha gị nke ọma.
Usoro ịkwụ ụgwọ?A ga-ebu ụzọ ziga akwụkwọ ọnụahịa Proforma mgbe nkwenye nke iwu, kpuchiri ozi ụlọ akụ anyị.Ịkwụ ụgwọ site na T/T (Telex Nyefee), PayPal, Western Union, wdg.
1- (1-Boc-4-Piperidinyl) -4-Iodopyrazole (CAS: 877399-73-0) na oke mma, etiti nke Crizotinib (CAS: 877399-52-5).Crizotinib bụ ọgwụ ezubere iche maka ọgwụgwọ ọrịa kansa akpa ume na-abụghị obere cell nke Pfizer, USA mepụtara, secorri bụ oke ala na ọgwụ na-eme oge na ngalaba ọgwụgwọ ezubere iche maka ọrịa kansa akpa ume.A kwadoro ya maka ịre ahịa na United States na August 2011 wee dee ya na ntụziaka ọgwụgwọ ọrịa cancer akpa ume mba ụwa na njedebe nke afọ dị ka ọgwụ mbụ maka ndị ọrịa ALK.Ejikọtara ya na Crizotinib bụ usoro nchọpụta mkpụrụ ndụ nke mbụ na-eji fluorescence in situ hybridization (FISH) -VSIs ALK Break Apart FISH Probe Kit, nke a bụ usoro a na-eji ugbu a na ule ụlọ ọgwụ zuru ụwa ọnụ iji chọpụta EML4-ALK fusion genes na NSCLC.Nnwale a ga-enyere aka chọpụta ndị ọrịa nwere ike irite uru na ọgwụgwọ Crizotinib.na 25, nke a bụ ọgwụ mbụ a ga-eji na-agwọ ndị ọrịa nwere ọrịa cancer nke mpaghara ma ọ bụ metastatic na-abụghị obere cell lung cancer (NSCLC) nke bụ anaplastic lymphoma kinase (ALK) -nke dị ka SFDA kwadoro nyocha.
Crizotinib (PF-02341066) Crizotinib bụ onye nwere ike c-Met na ALK inhibitor, ụkpụrụ IC50 dị na nyocha cell bụ 11 nM na 24 nM, n'otu n'otu.Ọ bụkwa onye na-egbochi ROS1 nwere uru Ki na-erughị 0.025 nM.Crizotinib nwere ike ibute autophagy n'ụdị ahịrị mkpụrụ ndụ kansa akpa ume site na igbochi ụzọ STAT3.
