CAS 945667-22-1 Ịdị ọcha>99.0% (HPLC) API

Nkọwa dị mkpirikpi:

CAS: 945667-22-1

Dị ọcha:> 99.0% (HPLC)

Ọdịdị: White ntụ ntụ

API, Ogo dị elu, mmepụta azụmahịa

E-Mail: alvin@ruifuchem.com

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Nkọwa:

Ruifu Chemical Supply Related Intermediates
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CAS 945667-22-1
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Boc-3-Hydroxy-1-Adamantyl-D-Glycine CAS 361442-00-4
(1S,3S,5S)-3-(Aminocarbonyl)-2-Azabicyclo [3.1.0]hexane-2-Carboxylic Acid tert-Butyl Ester CAS 361440-67-7
2- (3-Hydroxy-1-Adamantyl) -2-Oxoacetic Acid CAS 709031-28-7

Njirimara kemịkalụ:

Ụdị okwu	BMS-477118 Hydrate;Onglyza Hydrate;(1S,3S,5S) -2- [(2S) -2-Amino-2- (3-Hydroxy-1-Adamantyl) acetyl] -2-Azabicyclo [3.1.0] hexane-3-Carbonitrile Hydrate;(1S,3S,5S)-2-[(S)-2-Amino-2-[(1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl]acetyl]-2-Azabicyclo [3.1.0 ]hexane-3-carbonitrile hydrate
Nọmba CAS	945667-22-1
Nọmba CAT	RF-PI1992
Ọnọdụ Ahịa	N'ọkwa, Mpụta Ihe ruru Tọn
Usoro ihe omimi	C18H25N3O2·H2O
Ibu molekụla	333.43
Ụdị	Ruifu Chemical

Nkọwapụta:

Ihe	Nkọwapụta
Ọdịdị	Ọcha ntụ ntụ
njirimara	A: IR B: HPLC Ndokwa Oge
Ụzọ ịdị ọcha / nyocha	> 99.0% (HPLC, na akpọnwụ akpọnwụ)
Ọdịnaya Mmiri (KF)	5.3% ~ 7.3%
Ihe fọdụrụ na mgbanye	<0.20%
Otu adịghị ọcha	<0.50%
Mgbakọta adịghị ọcha	<1.00%
Ọla dị arọ	<10ppm
Arsenic (dị ka)	<2pm
Microbiology
Ngụkọta ọnụ ọgụgụ efere	<1000cfu/g
Yist & ebu	<100cfu/g
E. Coli	Ihe ọjọọ
S. Aureus	Ihe ọjọọ
Salmonella	Ihe ọjọọ
Ndụ shelf	Ọnwa 24
Nlele ọkọlọtọ	Standardkpụrụ ụlọ ọrụ
Ojiji	API;Ejiri ya maka ọgwụgwọ ụdị ọrịa shuga II

Ngwungwu & Nchekwa:

ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ

Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri

Uru:

Ajụjụ:

Ngwa:

API (CAS: 945667-22-1) bụ onye na-egbochi dipeptidyl peptidase-4 (DPP4) nke enwere ike iji mepụta ọgwụgwọ maka ụdị ọrịa shuga 2.Ọ bụ onye na-emechi ihe DPP4 na-agbanwe agbanwe na IC50 nke 26 nM na Ki nke 1.3 nM.IC50 uru: 26 nM.Ebumnuche: DPP4 in vitro: O nwere ihe mgbochi mgbe niile Ki nke 1.3 nM maka mgbochi DPP4, nke nwere ike okpukpu 10 karịa Sitagliptin (ndị inhibitors DPP4 abụọ ọzọ) yana Ki nke 13 na 18 nM.Na mgbakwunye, Ọ na-egosipụta nkọwa dị ukwuu maka DPP4 karịa maka ma ọ bụ DPP8 ma ọ bụ DPP9 enzymes (400- na 75-fold, n'otu n'otu).Metablite nọ n'ọrụ ya nwere ike okpukpu abụọ karịa nne na nna.Ha abụọ (CAS: 945667-22-1) na metabolite ya dị oke nhọrọ (> 4000-fold) maka mgbochi nke DPP4 ma e jiri ya tụnyere ọtụtụ proteases ndị ọzọ.(CAS: 945667-22-1) na-ebelata mmebi nke incretin hormone glucagon-dị ka peptide-1, si otú ahụ na-eme ka omume ya dịkwuo mma, ma jikọta ya na ọrụ β-cell na-eme ka ọ dịkwuo mma na nkwụsị nke glucagon secretion.in vivo: Ọ na-arụ ọrụ nke ọma. N'ịwepụta nkwalite dabere na dose na mkpochapụ glucose na oke dose 0.13-1.3 mg / kg na ụmụ oke ob/ob n'ihe metụtara njikwa.