4-Chloro-6-Iodoquinazoline CAS 98556-31-1 Ịdị ọcha>98.0% (HPLC)

4-Chloro-6-Iodoquinazoline (CAS: 98556-31-1) bụ etiti na njikọ nke Lapatinib (CAS: 231277-92-2) / Lapatinib Ditosylate Monohydrate (CAS: 388082-78-8).
Lapatinib bụ ọgwụ ọhụrụ ezubere iche maka ọgwụgwọ ọrịa ara ara nke GlaxoSmithKline mepụtara ma rụpụta ya, nke US Food and Drug Administration kwadoro na Machị 13, 2007. Ihe ngosi a kwadoro ugbu a na-ejikọta ya na capecitabine maka ọrịa cancer ara ma ọ bụ metastatic, yana ndị ọrịa kansa ara. a ga-eji ọgwụ ndị ọzọ na-ebute ụzọ gwọọ ya.Aha ahia ya na United States bụ Tykerb.Na Disemba 14, 2007, European Medicines Agency (EMEA) kwadoro ndepụta Lapatinib na Europe n'okpuru aha ahia Tyverb.Usoro ọgwụgwọ molecular ezubere iche maka ọrịa kansa ara na-ezo aka na ọgwụgwọ oncogenes na ngwaahịa okwu metụtara ya metụtara omume na mmepe nke ọrịa kansa ara.Ọgwụ ndị a na-ezubere iche na-egbochi ma ọ bụ gbuo mkpụrụ ndụ etuto site na igbochi ntụgharị mgbaàmà na mkpụrụ ndụ etuto ma ọ bụ sel ndị metụtara ya iji chịkwaa mgbanwe na mkpụrụ ndụ mkpụrụ ndụ cell.Lapatinib bụ ihe na-eme ka tyrosine kinase inhibitor na-eto eto nke obere molekul ọnụ.Nnwale ụlọ ọgwụ egosila na maka ndị ọrịa HER2 ọrịa ara ara bụ ndị mepụtara iguzogide Roche's Herceptin (Herceptin), Lapatinib nwere mmetụta dị mma n'ụlọ ọgwụ.Nnwale in vitro, Lapatinib nwere mmetụta mgbochi uto dị ukwuu na ahịrị mkpụrụ ndụ kansa ara nke Her-2.N'ime ule nke usoro nke mbụ nke ọrịa ara ara dị elu na Her-2 overexpression, Lapatinib nwekwara ọnụ ọgụgụ dị elu nke ọma na enweghị mgbochi mgbochi Herceptin (trastuzumab).N'ihi na nhazi ya bụ obere molekul, n'adịghị ka Herceptin (trastuzumab), ọ nwere ike banye n'ime ihe mgbochi ụbụrụ ọbara ma nwee mmetụta ọgwụgwọ ụfọdụ na ụbụrụ metastasis nke ọrịa ara ara.