Celecoxib CAS 169590-42-5 Assay 98.0 ~ 102.0%
Shanghai Ruifu Chemical Co., Ltd bụ onye na-emepụta Celecoxib (CAS: 169590-42-5) nwere oke mma.Ruifu Chemical nwere ike ịnye nnyefe zuru ụwa ọnụ, ọnụahịa asọmpi, ọrụ magburu onwe ya, obere na nnukwu ọnụọgụ dị.Ịzụta Celecoxib,Please contact: alvin@ruifuchem.com
| Aha Chemical | Celecoxib |
| Ụdị okwu | Celebrex;Ememe;Celecox;Onsenal;Solexa;SC-58635;SC 58635;YM-177;4-[5- (4-Methylphenyl) -3- (Trifluoromethyl) -1H-Pyrazol-1-yl] benzenesulfonamide;5- (4-Methylphenyl) -1- (4-Sulfamoylphenyl) -3- (Trifluoromethyl) pyrazole |
| Ọnọdụ Ahịa | Na ngwaahịa, Mmepụta Azụmahịa |
| Nọmba CAS | 169590-42-5 |
| Usoro ihe omimi | C17H14F3N3O2S |
| Ibu molekụla | 381.37 g/mol |
| Ebe Na-agbaze | 160.0 ruo 165.0 ℃ |
| Njupụta | 1.43±0.10 g/cm3 |
| Mmiri Solubility | Na-adịghị edozi n'ime mmiri |
| Solubility | Soluble nke ukwuu na methanol;Soluble na ethanol |
| COA & MSDS | Dị |
| Ihe atụ | Dị |
| Mmalite | Shanghai, China |
| Ụdị | Ruifu Chemical |
| Ihe | Ụkpụrụ nyocha | Nsonaazụ |
| Ọdịdị | White ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha kristal ntụ ntụ | Na-akwado |
| Nyocha | 98.0 ~ 102.0% | 99.8% |
| Ebe Na-agbaze | 160.0 ruo 165.0 ℃ | 162.2 ℃ |
| Mmiri nke Karl Fischer | <0.50% | 0.11% |
| Ihe fọdụrụ na mgbanye | <0.20% | 0.05% |
| Ọla dị arọ (Pb) | ≤20ppm | <10ppm |
| Ngwakọta emetụtara Celecoxib A | <0.40% | <0.20% |
| Ihe jikọrọ Celecoxib B | <0.10% | <0.10% |
| Ọdịghị ọcha n'otu n'otu na-akọwapụtaghị | <0.10% | <0.10% |
| Mgbakọta adịghị ọcha | <0.50% | 0.20% |
| Spectrum infrared | Nkwekọ na Structure | Na-akwado |
| 1H NMR Spectrum | Nkwekọ na Structure | Na-akwado |
| Mmechi | A nwalela ngwaahịa a wee kwado nkọwa ndị enyere | |
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Celecoxib
C17H14F3N3O2S 381.4
4-[5- (4-Methylphenyl) -3- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide;
p-[5-p-Tolyl-3- (trifluoromethyl) pyrazol-1-yl] benzenesulfonamide [169590-42-5]
Nkọwa
Celecoxib nwere NLT 98.0% na NMT 102.0% nke C17H14F3N3O2S, gbakọọ na anhydrous ndabere.
Nchọpụta
• A. INFRARED ABSORPTION <197>: [Ụzọ NDỤMỌDỤ <197A>, <197K>, ma ọ bụ <197M> n'okpuru absorption infrared nwere ike iji.]
[IHE-Ọ bụrụ na ụdịdị dị iche iche enwetara gosipụtara ọdịiche, gbarie ihe a ga-enyocha yana Standard Reference dị iche na mmanya isopropyl, kpochapu na nkụ, wee dekọọ ụdịdị ọhụrụ ahụ.]
• B. Oge njide nke isi ọnụ ọgụgụ kachasị elu nke ngwọta Sample dabara na nke Standard Solution, dị ka enwetara na Assay.
ASSAY
• Usoro
Nchekwa: 2.7 g/L nke monobasic potassium phosphate emeziri na phosphoric acid na pH nke 3.0 ± 0.2
Usoro mkpanaka: methanol, acetonitrile, na ihe nchekwa (3:1:6)
Ihe mgbaze: methanol na mmiri (3: 1)
Ngwọta ndabara sistemu: 0.5 mg/mL nke USP
Celecoxib RS na 2.4 µg/mL nke ọ bụla nke USP Celecoxib metụtara Compound A RS na USP Celecoxib metụtara Compound B RS na diluent
Ngwọta ọkọlọtọ: 0.5 mg/mL nke USP Celecoxib RS na diluent
Ngwọta nlele: 0.5 mg / ml nke Celecoxib na diluent
Sistemụ chromatographic
(Lee Chromatography <621>, Kwesịrị ekwesị Sistemu.)
Ụdị: LC
Ihe nchọpụta: UV 215 nm
Ogidi: 4.6-mm × 25-cm;5-µm nkwakọ ngwaahịa L11
Okpomọkụ kọlụm: 60°
Ọnụego mmiri: 1.5 ml / min
Nha igba ogwu: 25µL
Oge ịgba ọsọ: Ihe dịka 1.5 ugboro celecoxib elu elution
Sistemu kwesịrị ekwesị
Nlereanya: Ngwọta dabara adaba sistemu na ngwọta ọkọlọtọ
Kwesịrị ekwesị chọrọ
Mkpebi: NLT 1.8 n'etiti celecoxib metụtara compound A na Celecoxib na NLT 1.8 n'etiti Celecoxib na Celecoxib metụtara compound B, usoro dabara adaba
Ọkọlọtọ emetụtara: NMT 0.73%, Ọkọlọtọ ngwọta
Nyocha
Ihe atụ: Ngwọta ọkọlọtọ na ngwọta nlele
Gbakọọ pasent C17H14F3N3O2S na akụkụ Celecoxib were:
Nsonaazụ = (rU/rS) × (CS/CU) × 100
rU = nzaghachi kacha elu sitere na ngwọta Sample
rS = nzaghachi kacha elu sitere na ngwọta Standard
CS = itinye uche nke ngwọta ọkọlọtọ (mg/mL)
CU = itinye uche nke ngwọta nlele (mg/mL)
Usoro nnabata: 98.0% ~ 102.0% na ndabere anhydrous
IHE adịghị ọcha
Ihe adịghị ọcha
• Ọla dị arọ: NMT 20 ppm
Ihe mgbaze: acetone na mmiri (17: 3)
Ngwọta ọkọlọtọ: Dilute 1.0 ml nke Standard Lead Solution, kwadebere dị ka eduzi n'okpuru Heavy Metals <231>, Pụrụ iche Reagents, na diluent ka 20 ml.
Ngwọta nlele: igbari 0.50 g nke Celecoxib na 20ml nke diluent.
Ihe ngwọta efu: 20 ml nke diluent
Nyocha
Nlereanya: Ngwọta ọkọlọtọ, Ngwọta oghere, na ngwọta nlele
Na ngwọta ọ bụla, tinye 2 mL nke pH 3.5 Acetate Buffer kwadebere dị ka ntụziaka n'okpuru Heavy Metals <231>, Usoro I. Mix, ma gbakwunye na ngwọta ọ bụla 1.2 mL nke thioacetamide-glycerin base TS.Gwakọta ozugbo, ma kwe ka ị kwụrụ maka nkeji 2.Nyefee ihe ngwọta ahụ site na nzacha nke nha 0.45-µm.Tụlee ntụpọ ndị dị na nzacha enwetara site na nke ọ bụla n'ime ngwọta.
Nkwenye nnabata: Agba aja aja-oji nke ntụpọ ahụ sitere na ngwọta Sample adịghị ike karịa nke ntụpọ sitere na ngwọta Standard.Nnwale ahụ abaghị uru ma ọ bụrụ na ọkọlọtọ ọkọlọtọ egosighi agba aja aja-oji ma e jiri ya tụnyere ngwọta oghere.
• AKWỤKWỌ NA mgbanye <281>: NMT 0.2%, na-eji platinum crucible.
Ihe adịghị ọcha
• Usoro
Buffer, Usoro mkpanaaka, Diluent, Ngwọta dabara adaba sistemu, Ngwọta nlele, yana sistemu Chromatographic: Gaa n'ihu dị ka akwadoro na Assay.
Ngwọta ọkọlọtọ: 0.5 µg/mL nke USP Celecoxib RS na diluent
Sistemu kwesịrị ekwesị
Nlereanya: Ngwọta dabara adaba sistemu na ngwọta ọkọlọtọ
Kwesịrị ekwesị chọrọ
Mkpebi: NLT 1.8 n'etiti Celecoxib metụtara compound A na Celecoxib na NLT 1.8 n'etiti Celecoxib na Celecoxib metụtara compound B, ngwọta dabara na sistemụ
Oke mgbaàmà na mkpọtụ: NLT 20, Ọkọlọtọ ngwọta
Nyocha
Ihe atụ: Ngwọta ọkọlọtọ na ngwọta nlele
Gbakọọ pasent nke adịghị ọcha ọ bụla na akụkụ Celecoxib were:
Nsonaazụ = (rU/rS) × (CS/CU) × 100
rU = nzaghachi kacha elu maka adịghị ọcha ọ bụla na ngwọta Sample
rS = nzaghachi kacha elu nke celecoxib na ngwọta ọkọlọtọ
CS = ntinye nke celecoxib na ngwọta ọkọlọtọ (mg/mL)
CU = ntinye nke Celecoxib na ngwọta nlele (mg/mL)
Usoro nnabata
Ihe adịghị ọcha nke onwe: Lee Tebụl 1.
[MARA-eleghara ọnụ ọgụgụ adịghị ọcha ọ bụla na-erughị 0.05% anya]
Tebụl 1
| Aha | Oge Njide Oyiyi | Usoro nnabata NMT (%) |
| Ngwakọta metụtara Celecoxib Aa | 0.9 | 0.4 |
| Celecoxib | 1.0 | - |
| Ngwakọta metụtara Celecoxib Bb | 1.1 | 0.10 |
| Ihe adịghị ọcha nke onye ọ bụla na-akọwapụtaghị | - | 0.10 |
| Mgbakọta adịghị ọcha | - | 0.5 |
a 4-[5- (3-Methylphenyl) -3- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide.
b 4-[3- (4-Methylphenyl) -5- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide.
Nnwale akọwapụtara
• Mkpebi mmiri, Usoro I <921>: NMT 0.5%, na-eji ihe atụ 400-mg
NKWUO GBASARA YA
• Nkwakọba na Nchekwa: Chekwaa n'ime akpa siri ike, chebe ya pụọ na ìhè na mmiri mmiri.Na-echekwa na ụlọ okpomọkụ
• Ụkpụrụ ntụaka USP <11>
USP Celecoxib RS
p-[5-p-Tolyl-3- (trifluoromethyl) pyrazol-1-yl] benzenesulfonamide
C17H14F3N3O2S 381.4
Ngwakọta jikọrọ USP Celecoxib A RS
4-[5- (3-Methylphenyl) -3- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide.
C17H14F3N3O2S 381.4
Ihe jikọrọ USP Celecoxib B RS
4-[3- (4-Methylphenyl) -5- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide.
C17H14F3N3O2S 381.4
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Celecoxib na Rofecoxib bụ ihe mgbochi COX-2 na-eji ugbu a.Mepụtara nke ọma nke GD Searle & Pfizer Co. (US,) wepụtara na 1999, aha ahia: Celebrex.Celecoxib bụ onye na-abụghị steroidal, onye na-egbochi mkpali nke nwere mmetụta analgesic na mgbochi mkpali, na-eme ka ọnọdụ kachasị dị ala nke ọnya afọ eriri afọ na nsogbu ndị ọzọ.A na-eji ụlọ ọgwụ na-agwọ ọrịa ogbu na nkwonkwo na-adịghị ala ala na ọrịa ogbu na nkwonkwo, na-arụ ọrụ analgesic na-egbochi mkpali, na-ewepụ ihe ịrịba ama na mgbaàmà nke ọrịa ogbu na nkwonkwo na rheumatoid ogbu na nkwonkwo.
Celecoxib (CAS: 169590-42-5), Maka enyemaka na njikwa ọrịa ogbu na nkwonkwo (OA), ọrịa ogbu na nkwonkwo (RA), ọrịa ogbu na nkwonkwo na-eto eto (JRA), spondylitis ankylosing, nnukwu mgbu, isi dysmenorrhea na ntinye ọnụ na-elekọta ndị ọrịa. na ezinụlọ adenomatous polyposis.
Celecoxib (CAS: 169590-42-5) nwere mgbochi mkpali na analgesic mmetụta nke NSAIDs.N'ihi nhazi kemịkalụ ya, enwere ike ijikọ ya na COX-2, na-ahọrọ ya na-egbochi COX-2.Otu phenyl ya jikọtara ya na ọwa hydrophobic nke COX-2, na hydrophilic sulfonamide ya na-etolite agbụ hydrogen nwere 513 arginine na 90 histidine na COX-2 "akpa n'akụkụ."Ọ dịkwa nso na arginine na ọnọdụ COX-2120 ma na-ekere òkè na igbochi COX-2 ka ọ gbanwee arachidonic acid ka ọ bụrụ prostaglandins nke na-emerụ ahụ mmadụ n'ihi ọdịiche dị nro dị n'etiti ihe owuwu nke COX-1 na COX. -2, Celecoxib enweghị ike ịbanye na molekul COX-1, ma ọ bụ gbochie mgbanwe nke arachidonic acid n'ime prostaglandins. nsogbu mgbakasị ahụ nke NSAID ndị a na-ejikarị eme ihe.
A na-egosi Celecoxib (CAS: 169590-42-5) maka ọgwụgwọ osteoarthritis na ọrịa ogbu na nkwonkwo.A machibidoro iji ya mee ihe na ndị mmadụ nwere hypersensitivity na sulfonamides ma ọ bụ NSAID ndị ọzọ.Ekwesịrị iji nlezianya mee ya na ndị nwere ọrịa imeju.Mmekọrịta na-eme na ọgwụ ndị ọzọ na-ebute CYP2C9 (dịka rifampin rifampin) ma ọ bụ na-asọmpi maka metabolism site na enzyme a (dịka fluconazole, leflunomide).Mmeghachi omume ọjọọ na-emekarị na celecoxib bụ mmetụta GI dị nro na nke na-adịghị mma dị ka dyspepsia, afọ ọsịsa, na mgbu afọ.GI siri ike na mmetụta gbasara akụrụ adịkarịghị.
