Chloramphenicol CAS 56-75-7 Dị Ọcha ≥99.0% (HPLC) ịdị ọcha dị elu
Onye na-emepụta ihe nwere ịdị ọcha dị elu na mmepụta azụmahịa
(1R,2R)-(-)-2-Amino-1- (4-nitrophenyl) -1,3-propanediol CAS 716-61-0
(1S,2S)-(+) -2-Amino-1- (4-nitrophenyl) -1,3-propanediol CAS 2964-48-9
Chloramphenicol CAS 56-75-7
Aha Chemical | Chloramphenicol |
Ụdị okwu | D (-) -threo-2-Dichloroacetamido-1- (4-nitrophenyl) -1,3-propanediol;2,2-Dichloro-N-[(1R,2R) -1,3-dihydroxy-1- (4-nitrophenyl) -2-propyl] acetamide. |
Nọmba CAS | 56-75-7 |
Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
Usoro ihe omimi | C11H12Cl2N2O5 |
Ibu molekụla | 323.13 |
Ebe Na-agbaze | 149.0 ruo 153.0 ℃ (ọkụ) |
Mmetụta | Ìhè nwere mmetụta |
Solubility | Soluble na Ethanol, Methanol, Acetone.Soluble na Ether, Chloroform.Na-adịghị edozi na Benzene.Ihe Na-adịghị Mma Na Mmiri |
Ọnọdụ mbupu | Ebugara n'okpuru okpomọkụ gburugburu |
COA & MSDS | Dị |
Mmalite | Shanghai, China |
Ụdị | Ruifu Chemical |
Ihe | Nkọwapụta |
Ọdịdị | Ọcha na-acha odo odo ntụ ntụ |
njirimara A | Infrared absorption |
njirimara B | Oge njide nke nnukwu ọnụ ọgụgụ dị elu na chromatogram nke nkwadebe Assay kwekọrọ na chromatogram nke nkwadebe Standard, dị ka enwetara na Assay. |
Ntụgharị ngwa anya akọwapụtara | +17.0°~+20.0° |
Ebe Na-agbaze | 149.0 ~ 153.0 ℃ |
Crystallinity | Na-emezu ihe achọrọ |
pH | 4.5-7.5 |
Otu adịghị ọcha | ≤0.50% |
Mgbakọta adịghị ọcha | ≤1.00% |
Ọla dị arọ | ≤20ppm |
Arsenic | ≤1pm |
Ọnwụ na ihicha | ≤0.50% (105 ℃, 3 awa) |
Ihe fọdụrụ na mgbanye | ≤0.10% |
Ụzọ ịdị ọcha / nyocha | ≥99.0% (HPLC) |
Nlele ọkọlọtọ | Ụkpụrụ ụlọ ọrụ;JP;USP |
ngwugwu: Kalama, Aluminom foil bag, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè, mmiri mmiri.
Chloramphenicol
C11H12Cl2N2O5 323.13 [56-75-7].
Chloramphenicol nwere ihe na-erughị 97.0 pasent na ọ bụghị karịa 103.0 pasent nke C11H12Cl2N2O5.
Nkwakọ ngwaahịa na nchekwa - Chekwaa n'ime akpa siri ike.
Labeling-Ebe e bu n'obi ka e jiri ya mee ihe n'ịkwadebe ụdị ọgwụgwọ injectable ma ọ bụ ihe ndị ọzọ na-adịghị mma, akara ahụ na-ekwu na ọ dịghị mma ma ọ bụ na a ga-edozi ya n'ihu nhazi n'oge nkwadebe nke injectable ma ọ bụ ndị ọzọ na-edozi usoro onunu ogwu.
Ụkpụrụ ntụaka USP <11>-
USP Chloramphenicol RS Pịa ka ilele Ọdịdị
USP Endotoxin RS
njirimara-
A: Infrared absorption <197K>.
B: Oge njide nke nnukwu ọnụ ọgụgụ dị elu na chromatogram nke nkwadebe Assay kwekọrọ na nke ahụ na chromatogram nke nkwadebe Standard, dị ka enwetara na Assay.
Oke agbaze <741>: n'etiti 149 na 153.
Ntụgharị a kapịrị ọnụ <781S>: n'etiti +17.0 na +20.0.
Ngwọta ule: 50 mg, akpọghị nkụ, kwa mL, na mmanya na-egbu egbu.
Crystallinity <695>: na-emezu ihe achọrọ.
Endotoxins nke nje bacteria 85-Ebe Chloramphenicol echere maka iji na-akwadebe ụdị ọgwụgwọ injectable, ọ nwere ihe karịrị 0.2 USP Endotoxin Unit kwa mg nke chloramphenicol.
Sterilite 71- Ebe akara ahụ na-ekwu na Chloramphenicol adịghị ike, ọ na-emezu ihe achọrọ mgbe a nwalere ya ka akwadoro maka Membrane Filtration n'okpuru Nnwale maka Ịdị Ike nke Ngwaahịa a ga-enyocha, ma e wezụga iji 1 g nke ụdị ihe siri ike.
pH <791>: n'etiti 4.5 na 7.5, na nkwusioru mmiri nwere 25 mg kwa ml.
Ịdị ọcha Chromatographic - Gbazee ọnụọgụ Chloramphenicol nke a tụrụ nke ọma na methanol iji nweta ngwọta nnwale nwere 10 mg kwa ml.Kwadebe ihe ngwọta nke USP Chloramphenicol RS na methanol nwere 10 mg kwa ml (Standard solution A).Jiri methanol gbanye akụkụ nke ihe ngwọta ọkọlọtọ A nke ọma iji nweta ngwọta ọkọlọtọ B nwere 100 µg kwa ml yana ọkọlọtọ ọkọlọtọ C nwere 50 μg kwa ml.Tinye akụkụ 20-µL dị iche iche nke ngwọta nnwale yana ọkọlọtọ ọkọlọtọ B na C gaa na efere chromatographic dị gịrịgịrị dabara adaba (lee Chromatography 621), kpuchie ya na akwa 0.25-mm nke ngwakọta silica chromatographic chromatographic.Zụlite chromatogram n'ime usoro ihe mgbaze nke nwere ngwakọta nke chloroform, methanol, na glacial acetic acid (79:14:7) ruo mgbe ihu ihe mgbaze na-ebugharị ihe dị ka ụzọ atọ n'ụzọ anọ nke ogologo efere ahụ.Wepu efere ahụ n'ime ụlọ ahụ, kpoo ikuku, wee nyochaa n'okpuru ọkụ UV dị mkpụmkpụ: ntụpọ ọ bụla na-abụghị isi ebe a na-enweta site na ngwọta ule anaghị agafe n'ogo ma ọ bụ ike isi ebe a nwetara site na Standard Solution B (1% ), na nchikota nke adịghị ọcha na-anọchi anya ntụpọ niile na-abụghị isi ntụpọ, dabere na ntụnyere ike nke ntụpọ dị otú ahụ na ike nke isi ntụpọ enwetara site na Standard Solution B na C, anaghị agafe 2% .
Nyocha -
Usoro mkpanaaka - Kwadebe ngwakọta mmiri, methanol, na glacial acetic acid kwesịrị ekwesị (55:45:0.1).Mee mgbanwe ọ bụrụ na ọ dị mkpa (lee Dabara Sistemu n'okpuru Chromatography 621).
Nkwadebe ọkọlọtọ- Gbanyụọ ọnụọgụ USP Chloramphenicol RS n'ụzọ ziri ezi na usoro mkpanaaka, wee tụgharịa n'ụzọ dị iche iche, yana n'usoro ma ọ bụrụ na ọ dị mkpa, yana usoro mkpanaaka iji nweta ihe ngwọta nwere njiri mara nke ihe dịka 80 µg kwa ml.Wepụta akụkụ nke ngwọta a site na nzacha 0.5-µm ma ọ bụ mma porosity, wee jiri nzacha doro anya dị ka nkwadebe ọkọlọtọ.
Nkwadebe nyocha- Nyefee ihe dị ka 200 mg nke Chloramphenicol, tụọ ya nke ọma, na flask volumetric 100-mL, tinye usoro mkpanaka na olu, ma gwakọta.Nyefee 4.0 ml nke ihe ngwọta a ga-esi na ya pụta na flask volumetric 100-mL, gbanye ya na usoro Mobile ka ọ bụrụ olu, na mix.Wepụta akụkụ nke ngwọta a site na nzacha 0.5-µm ma ọ bụ mma porosity, ma jiri nzacha doro anya dị ka nkwadebe Assay.
Usoro Chromatographic (lee Chromatography <621>) -Kromatograph mmiri mmiri nwere ihe nchọta 280-nm yana kọlụm 4.6mm × 10-cm nke nwere 5-µm mbukota L1.Ọnụego mmiri ahụ bụ ihe dịka 1 ml kwa nkeji.Chromatograph the Standard nkwadebe, wee dekọọ nzaghachi kacha elu dị ka a na-eduzi n'okpuru Usoro: arụmọrụ kọlụm ekpebisiri ike site na ọnụ ọgụgụ nyocha erughị 1800 efere usoro ihe omume, ihe ọdụdụ ahụ abụghị ihe karịrị 2.0, yana ndakọrịta ọkọlọtọ maka injections ugboro ugboro abụghị ihe karịrị 2.0. karịa 1.0%.
Usoro-[ ndetu-Jiri elu elu ebe egosiri nzaghachi kacha elu.] Kewapụ iche, gbanye nha nha nha (ihe dịka 10 µL) nke nkwadebe Standard na nkwadebe Assay n'ime chromatograph, dekọọ chromatogram, ma tụọ azịza maka ọnụ ọgụgụ ndị bụ isi.Gbakọọ ọnụọgụ, na mg, nke C11H12Cl2N2O5 n'ime akụkụ Chloramphenicol nke usoro a were were:
2.5C (rU / rS)
nke C bụ ntinye uche, na µg kwa ml, nke USP Chloramphenicol RS na nkwadebe Standard, na rU na rS bụ nzaghachi kachasị elu nke enwetara site na nkwadebe Assay na Standard nkwadebe, n'otu n'otu.
Chloramphenicol
C11H12Cl2N2O5: 323.13
2,2-Dichloro-N-[(1R,2R) -1,3-dihydroxy-1- (4-nitrophenyl) propan-2-yl] acetamide [56-75-7]
Chloramphenicol nwere ọ bụghị ihe na-erughị 980 mg (ike) na ọ bụghị ihe karịrị 1020 mg (ike) kwa mg, gbakọọ na akpọnwụwo ndabere.A na-egosipụta ike nke Chloramphenicol dị ka oke (ike) nke chloramphenicol (C11H12Cl2N2O5).
Nkọwa Chloramphenicol pụtara dị ka ọcha na-acha ọcha na-acha odo odo, kristal ma ọ bụ kristal ntụ ntụ.
Ọ bụ n'efu soluble na methanol na ethanol (99.5), na ntakịrị soluble na mmiri.
Identification (1) Kpebisie ike na absorption ụdịdị dị iche iche nke sample ngwọta enwetara na Assay dị ka eduzi n'okpuru Ultraviolet-visible Spectrophotometry <2.24>, ma tụnyere ụdịdị dị iche iche na Reference Spectrum ma ọ bụ ụdịdị dị iche iche nke ngwọta nke Chloramphenicol RS kwadebere n'otu ụzọ ahụ. Ngwọta ihe atụ: ma ụdịdị dị iche iche na-egosipụta ụdị ike nke mmịkọ n'otu ogologo wavelength.
(2) Kpebisie ike na infrared absorption spectrum nke Chloramphenicol dị ka eduzi ya na potassium bromide disk usoro n'okpuru Infrared Spectrophotometry <2.25>, ma tụnyere ụdịdị dị iche iche na Reference Spectrum ma ọ bụ ụdịdị nke Chloramphenicol RS: ụdịdị abụọ ahụ na-egosipụta ike nke absorption n'otu oge. nọmba ife efe.
Ntugharị anya <2.49> [a] 20D: +18.5 ~ + 21.5℃ (1.25 g, ethanol (99.5), 25 ml, 100 mm.
Ebe mgbaze <2.60> 150 ~ 155 ℃
Ịdị ọcha (1) ọla dị arọ <1.07>-Gaa na 1.0 g nke Chloramphenicol dịka usoro 2 siri dị, wee mee ule ahụ.Kwadebe ngwọta njikwa na 2.5 ml nke Standard Lead Solution (ọ bụghị karịa 25 ppm).
(2) Arsenic <1.11> - Kwadebe ngwọta ule na 2.0 g nke Chloramphenicol dị ka usoro 4 si dị, ma mee ule ahụ (ọ bụghị karịa 1 ppm).
(3) Ihe ndị metụtara ya - gbazee 0.10 g nke Chloramphenicol na 10 ml nke methanol, ma jiri ngwọta a dị ka ngwọta nlele.Pipet 1 ml nke ihe nlele, gbakwunye methanol iji mee 100 ml kpọmkwem, ma jiri ngwọta a dị ka ọkọlọtọ ọkọlọtọ (1).Pipet 10 mL nke ọkọlọtọ ọkọlọtọ (1), tinye methanol ka ọ mee kpọmkwem 20 ml, ma jiri ngwọta a dị ka ọkọlọtọ ọkọlọtọ (2).Jiri ngwọta ndị a mee nnwale ahụ dị ka a gwara gị n'okpuru Chromatography nke Thin-Layer <2.03>.Ntụpọ 20 mL nke ọ bụla n'ime ihe ngwọta nlele na ngwọta ọkọlọtọ (1) na (2) na efere silica gel na-egosi fluorescent maka chromatography nke dị warara, mepụta efere ahụ na ngwakọta nke chloroform, methanol na acetic acid (100) (100). 79:14:7) n’ebe dị ihe dị ka cm 15, ma kpochaa efere ahụ.Nyochaa n'okpuru ọkụ ultraviolet (isi n'ogologo: 254 nm): ntụpọ ndị ọzọ na-abụghị isi ntụpọ na ebe dị na mbụ nke enwetara site na ngwọta nlele adịghị ike karịa ebe enwetara site na ọkọlọtọ ọkọlọtọ (1), na ngụkọta amunt. nke ntụpọ ndị a sitere na ngwọta nlele adịghị karịa 2.0%.
Ọnwụ na ihicha <2.41> Ọ bụghị ihe karịrị 0.5% (1 g, 105 ℃, 3 awa).
Ihe fọdụrụ na mgbanye <2.44> Ọ bụghị karịa 0.1% (1 g).
Assay tụọ nke ọma ego Chloramphenicol na Chloramphenicol RS, nke dabara ihe dị ka 0.1 g (ike), gbarie nke ọ bụla n'ime 20 ml nke methanol, ma gbakwunye mmiri iji mee 100 ml.Pipet 20 ml nke ọ bụla n'ime ihe ngwọta ndị a, ma gbakwunye mmiri iji mee kpọmkwem 100 ml.Pipet 10 mL nke ọ bụla n'ime ihe ngwọta ndị a, gbakwunye mmiri iji mee kpọmkwem 100 ml, ma jiri ngwọta ndị a dị ka ihe ngwọta na ngwọta ọkọlọtọ.Kpebie ihe ndị na-anabata ya, AT na AS, na 278 nm nke ngwọta nlele na ngwọta ọkọlọtọ dị ka eduzi n'okpuru Ultraviolet-visible Spectrophotometry <2.24>.
Ọnụ ego [mg (ike)] nke chloramphenicol (C11H12Cl2N2O5)
= MS × AT/AS × 1000
MS: Ọnụ ego [mg (ike)] nke Chloramphenicol RS
were
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Koodu ihe ize ndụ R45 - nwere ike ibute ọrịa kansa
R11 - Na-agba ọkụ nke ukwuu
R39/23/24/25 -
R23/24/25 - Na-egbu egbu site na iku ume, na kọntaktị na akpụkpọ ahụ ma ọ bụrụ na iloro ya.
Nkọwa nchekwa S53 - Zena mkpughe - nweta ntuziaka pụrụ iche tupu ejiri ya.
S45 - Ọ bụrụ na ihe mberede ma ọ bụ ọ bụrụ na ahụ adịghị gị mma, chọọ ndụmọdụ ahụike ozugbo (gosi akara ahụ mgbe ọ bụla enwere ike.)
S16 - Wepụ ya na isi mmalite nke mgbanye.
S36/37 - Yiri uwe nchebe kwesịrị ekwesị na uwe aka.
NJ UN 2811
WGK Germany 3
RTECS AB6825000
FLUKA BRAND F CODES 3-10
TSCA Ee
Koodu mpaghara:: 2941400000
Klas 3 egwu
Nsi LD50 ọnụ na oke: 2500mg/kg
P501: Tụfuo ọdịnaya/akpa n'ụlọ ọrụ mkpofu akwadoro.
P260: Ekula uzuzu / uzuzu / gas / alụlụ / vapors / ịgba.
P270: erila, aṅụ ma ọ bụ anwụrụ ọkụ mgbe ị na-eji ngwaahịa a.
P202: Ejila ruo mgbe agụchara ma ghọta ihe nchekwa nchekwa niile.
P201: Nweta ntuziaka pụrụ iche tupu ejiri ya.
P264: saa anụ ahụ nke ọma mgbe ejirichara ya.
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P405: Akpọchiri ụlọ ahịa.
Shanghai Ruifu Chemical Co., Ltd bụ onye na-ebubata Chloramphenicol (CAS: 56-75-7) nwere oke mma.Chloramphenicol bụ ọgwụ nje na-egbu egbu nke ukwuu, nke bụ nhọrọ mbụ maka ọgwụgwọ typhoid na paratyphoid, nke abụọ, a na-eji ya agwọ ọrịa dị iche iche na-efe efe nke microorganisms nwere mmetụta na-akpata.N'ihi oké njọ oghom Jeremaya mere na-eji ugbu a obere na obere.Ụdị dị iche iche nke nje bacteria, ọrụ na ojiji bụ otu ihe ahụ dị ka chloramphenicol maka ọgwụgwọ Salmonella Typhi, Shigella, Escherichia coli, influenza, Brucella, ọrịa oyi baa nke cocci na ọgwụ nje ndị ọzọ na-egbochi ọrịa.A na-ejikarị Chloramphenicol na-agwọ ọrịa urinary tract, oyi baa, ọrịa afọ na septicemia nke nje bacteria na-enwe mmetụta na-akpata, yana nsị anya na mpụga ntị.
UN3249 Ọgwụ, siri ike, na-egbu egbu, mba, Klaasị ihe egwu: 6.1;Ihe akara: 6.1-ihe na-egbu egbu.UN2811 Ihe siri ike na-egbu egbu, organic, nos, Klaasị egwu: 6.1;Akara aha: 6.1- Ihe na-egbu egbu, Aha nka achọrọ.