Dantrolene Sodium Salt Hydrate CAS 14663-23-1 API Ụlọ ọrụ dị elu
Nye ya na ịdị ọcha dị elu yana ịdị mma kwụsie ike
Aha Kemịkal: Dantrolene Sodium Salt Hydrate
OZI: 14663-23-1
Ọkpụkpụ akwara na-ezu ike.Ihe mgbochi ọwa Calcium
API Ogo dị elu, mmepụta azụmahịa
| Aha Chemical | Dantrolene sodium nnu hydrate |
| Ụdị okwu | 1-[5- (4-Nitrophenyl)furfurylideneamino]hydantoin sodium nnu hydrate. |
| Nọmba CAS | 14663-23-1 |
| Nọmba CAT | RF-API78 |
| Ọnọdụ Ahịa | Na Akụrụngwa, Mpụta Ihe ruru narị narị kilograms |
| Usoro ihe omimi | C14H11N4NaO5 |
| Ibu molekụla | 338.25 |
| Solubility | Soluble na DMSO |
| Ọnọdụ mbupu | Ebugara n'okpuru okpomọkụ gburugburu |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta |
| Ọdịdị | Yellowish-Oranji ruo ntụ ntụ kristal oroma.Enweghị ihe akaebe a na-ahụ anya nke mmetọ site na ihe si mba ọzọ |
| njirimara A | Ntinye nke IR (197K) |
| njirimara B | Oge njide nke nnukwu ọnụ ọgụgụ dị elu na chromatogram nke nkwadebe nyocha ahụ kwekọrọ na nke ahụ na chromatogram nke nkwadebe ọkọlọtọ, dị ka enwetara na nyocha. |
| njirimara C | Zutere ihe achọrọ maka nnwale ọkụ maka sodium (191) |
| njirimara D | Nkebi nke 1: A na-emepụta nnukwu mmiri, ọcha, kristal Nkebi 2: Ọsọ mmiri anaghị apụ apụ Nkebi nke 3: The precipitate dissolves kpamkpam Nkebi nke 4: A naghị emepụta mmiri ozuzo |
| Ọdịnaya mmiri (nke KF) | 14.5% ~ 17.0% |
| Nha urughuru | 90% erughị 200um |
| Nyocha | 90.0% ~ 96.0% nke C14H10N405 na anhydrous ndabere |
| Ihe ndị emetụtara | (HPLC, Mpaghara%) |
| Ngwakọta emetụtara A | ≤0.15% |
| Ngwakọta emetụtara B | ≤0.50% |
| Ngwakọta emetụtara C | ≤0.30% |
| Ihe mgbaze fọdụrụnụ | |
| Ethanol | ≤2000ppm |
| Methanol | ≤2000ppm |
| Acetone | ≤2000ppm |
| DMF | ≤620ppm |
| Ọla dị arọ | ≤10ppm |
| Ndụ shelf | afọ 2 |
| Nlele ọkọlọtọ | United States Pharmacopoeia (USP) |
| Ojiji | Ọkpụkpụ akwara na-ezu ike.Ihe mgbochi ọwa Calcium |
ngwugwu: Kalama, Aluminom foil bag, kaadiboodu drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.
Dantrolene Sodium Salt Hydrate (CAS 14663-23-1), bụ obere ihe mgbochi molecule nke Ryanodine receptor antagonist na Calcium channel inhibitor.Dantrolene Sodium Salt bụ ihe na-eme ka anụ ahụ dị jụụ, nke na-egbochi intracellular Ca 2+ ntọhapụ site na sarcoplasmic reticulum.Mgbochi nke Ca2 + ntọhapụ sitere na sarcoendoplasmic reticulum, nke nwere njikọ siri ike na mkpali na mkpirisi akwara, na-ebute mmetụta ntụrụndụ nke anụ ahụ jikọtara ya na Dantrolene.A na-ejikọta neurotoxicity nke ọrụ glutamate akpọpụtara na oke ịrị elu na ọkwa cytoplasmic Ca2 +, yana Dantrolene gosipụtara dị ka onye na-ahụ maka neuroprotective megide excitotoxicity nke neurotrasmitter kpatara.Dantrolene, sodium nnu bụ ihe mgbochi nke RyR-1 na RyR-3.
