DAPT (GSI-IX) CAS 208255-80-5 γ-Secretase Inhibitor Assay> 98.0% (HPLC) Ụlọ ọrụ
Shanghai Ruifu Chemical Co., Ltd. bụ onye na-emepụta DAPT (GSI-IX) (CAS: 208255-80-5) nwere àgwà dị elu, γ-Secretase Inhibitor.Ruifu Chemical na-enye usoro amino asịd na ihe mpụta.Anyị nwere ike ịnye nnyefe zuru ụwa ọnụ, obere na nnukwu ọnụọgụ dị.Zụrụ DAPT,Please contact: alvin@ruifuchem.com
| Aha Chemical | DAPT |
| Ụdị okwu | GSI-IX;γ-ihe mgbochi nzuzo IX;ihe mgbochi gamma-Secretase;LY-374973;(3,5-Difluorophenylacetyl) -Ala-Phg-OtBu;(3,5-Difluorophenylacetyl) -L-Alanyl-L-2-Phenylglycine tert-Butyl Ester;N-[N- (3,5-Difluorophenacetyl)-L-Alanyl]-S-Phenylglycine t-Butyl Ester;(2S)-N-[2- (3,5-Difluorophenyl) acetyl] -L-Alanyl-2-Phenyl-glycine 1,1-Dimethylethyl Ester |
| Ọnọdụ Ahịa | Dị na ngwaahịa |
| Nọmba CAS | 208255-80-5 |
| Usoro ihe omimi | C23H26F2N2O4 |
| Ibu molekụla | 432.47 |
| Njupụta | 1.213 g/cm3 |
| Ebe Na-agbaze | 142.0 ~ 146.0 ℃ |
| Mmetụta | Okpomọkụ nwere mmetụta |
| Solubility | Soluble na DMSO |
| Okpomọkụ nchekwa. | Na-echekwa na 2-8 ℃ |
| COA & MSDS | Dị |
| Ụdị | Ruifu Chemical |
| Nkwupụta nchekwa | 24/25 - Zere kọntaktị na akpụkpọ ahụ na anya. | ||
| WGK Germany | 3 | Koodu HS | 2922491990 |
| Ihe | Ụkpụrụ nyocha | Nsonaazụ |
| Ọdịdị | Ntụ ntụ kristal na-acha ọcha ma ọ bụ gbanyụọ | Dabara |
| Ọnwụ na ihicha | <0.40% | 0.21% |
| Ihe fọdụrụ na mgbanye | <0.40% | 0.20% |
| Ọla dị arọ (dị ka Pb) | ≤20ppm | <20ppm |
| Usoro nyocha / nyocha | > 98.0% (HPLC) | 98.62% |
| Carbon site na nyocha ihe | 62.1 ~ 64.1% | Dabara |
| Nitrogen site Elemental Analysis | 6.20 ~ 6.70% | Dabara |
| Spectrum infrared | Dabara na Ọdịdị | Dabara |
| Ọnụ ego nke NMR Spectrum | Dabara na Ọdịdị | Dabara |
| Mmechi | Ngwaahịa a site na nkwekọrịta nyocha na ọkọlọtọ ụlọ ọrụ | |
| Ndụ shelf | Ọnwa 24 Site na ụbọchị nrụpụta ma ọ bụrụ na echekwara ya nke ọma | |
ngwugwu: Fluorinated Bottle, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Chekwaa n'ime akpa mkpuchi mkpuchi dị jụụ, kpọrọ nkụ (echekwara na 2-8℃) yana ụlọ nkwakọba ihe ikuku na-adịghị na ihe ndị na-adabaghị adaba.Chebe site na ìhè na mmiri mmiri.
Kedu ka esi azụta?Biko kpọtụrụDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Ahụmịhe afọ 15?Anyị nwere ihe karịrị 15 afọ nke ahụmahụ na mmepụta na mbupụ nke a dịgasị iche iche nke elu mma pharmaceutical intermediates ma ọ bụ ezi kemịkal.
Isi ahịa?Na-ere ahịa ụlọ, North America, Europe, India, Korea, Japanese, Australia, wdg.
Uru?Ogo kachasị elu, ọnụ ahịa dị ọnụ ala, ọrụ ọkachamara na nkwado teknụzụ, nnyefe ngwa ngwa.
OgoNkwenye?Usoro njikwa mma siri ike.Ngwá ọrụ ọkachamara maka nyocha gụnyere NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, wdg.
Ihe atụ?Ọtụtụ ngwaahịa na-enye ihe nlele efu maka nyocha dị mma, ndị ahịa kwesịrị ịkwụ ụgwọ mbupu.
Nyocha ụlọ ọrụ?Nnabata nyocha ụlọ ọrụ.Biko mee oge oge tupu oge eruo.
MOQ?Enweghị MOQ.A na-anabata obere usoro.
Oge Mbuga ozi? Ọ bụrụ n'ime ngwaahịa, ekwenyere nnyefe ụbọchị atọ.
Ụgbọ njem?Site Express (FedEx, DHL), nke ikuku, site n'oké osimiri.
Akwụkwọ?Mgbe ọrụ ahịa gasịrị: COA, MOA, ROS, MSDS, wdg nwere ike ịnye.
Synthesis omenala?Nwere ike ịnye ọrụ nhazi ahaziri iche ka ọ dabara mkpa nyocha gị nke ọma.
Usoro ịkwụ ụgwọ?A ga-ebu ụzọ ziga akwụkwọ ọnụahịa Proforma mgbe nkwenye nke iwu, kpuchiri ozi ụlọ akụ anyị.Ịkwụ ụgwọ site na T/T (Telex Nyefee), PayPal, Western Union, wdg.
DAPT (GSI-IX) (CAS: 208255-80-5), ihe mgbochi siri ike na kpọmkwem nke γ-secretase.DAPT bụ ihe mgbochi nke γ-secretase (IC50 na neurons bụ isi mmadụ = 115 nM maka ngụkọta Aβ ma ọ bụ 200 nM maka Aβ42 kpọmkwem).E gosiputara nchịkwa ọnụ nke DAPT iji belata ọkwa nke Aβ na ụbụrụ ụbụrụ, mmiri cerebrospinal na plasma sitere na ụmụ oke na oke.DAPT na-egbochi akara ngosi Notch nke na-akwalite ọdịiche neuronal nke sel ndị mbụ.Na-akwalite sel iPS na-enweghị oncogenes KLF4 na CMYC5.Cell permeable.A na-eji DAPT eme ihe n'ọmụmụ ihe gbasara nhazi β-amyloid.E gosiputara DAPT ka ọ gbochie Notch nrịbama n'ọmụmụ ihe gbasara ọrịa autoimmune na lymphoproliferative, dị ka ALPS na lupus erythematosus, yana na mkpụrụ ndụ cancer cancer, angiogenesis, na ọdịiche nke mmadụ na-ebute sel pluripotent.Na-egbochi nrịbama Notch in vitro.Na-egbochi mkpokọta Aβ na Aβ42 mmepụta na omenala ndị mmadụ (ụkpụrụ IC50 bụ 115 na 200 nM, n'otu n'otu) na-enweghị mmetụta na ọkwa APPα na APPβ.Ihe mgbochi ọbara-ụbụrụ na-agafe agafe.Akụkụ matriks uto 3D na akụkụ nke mgbasa ozi ọdịiche organoid cerebral.
