Daptomycin CAS 103060-53-3 Ịdị Ọcha ≥95.0% API Ụlọ Ọrụ Dị Ọcha Dị Elu

Daptomycin (CAS: 103060-53-3) bụ ụdị ọgwụ nje lipopeptide cyclic nwere usoro ọhụụ.A na-ewepụta ya na broth Streptomyces gbaa ụka.Ụlọ ọrụ Eli Lilly chọtara ya na 1980, wee mepụta nke ọma na 1997 site na Cubist Pharmaceuticals.Ọ bụghị naanị na ọ nwere usoro kemịkalụ ọhụụ mana ọ nwekwara usoro omume nke dị iche na ọgwụ nje ọ bụla akwadoro na mbụ: ọ na-egbochi cell site na imebi ibufe amino acid site na akpụkpọ ahụ, si otú a na-egbochi mgbidi cell peptidoglycan biosynthesis na ịgbanwe ọdịdị nke akpụkpọ ahụ cell.Ọ nwere ike imebi akpụkpọ ahụ sel nke nje bacteria n'ọtụtụ akụkụ, wee gbuo nje bacteria na-adị mma ngwa ngwa.Na mgbakwunye na ọrụ nke na-emetụta ọtụtụ nje bacteria na-emetụta gram-positive, nke ka mkpa, Daptomycin nwere mmetụta dị ike n'ịgwọ ụdị dịpụrụ adịpụ nke gosipụtara ihe ịrịba ama nke iguzogide methicillin, vancomycin na linezolid.Ihe onwunwe a bara ezigbo uru maka ndị ọrịa na-arịa ọrịa siri ike.Na Septemba 2003, nchịkwa nri na ọgwụ ọjọọ nke United States kwadoro na nke mbụ na Daptomycin (CAS: 103060-53-3) nwere ike itinye maka ọgwụgwọ nke ọrịa akpụkpọ anụ siri ike.Na March 2006, a kwadoro ya maka ịgwọ ọrịa na-efe efe.Na Jenụwarị 2006, European Commission kwadoro ya maka ọgwụgwọ ụfọdụ akpụkpọ anụ na anụ ahụ dị nro nke nje bacteria gram-positive kpatara.Na Septemba 6, 2007, Cubist Pharmaceuticals kwupụtara na European Union akwadola ọgwụ nje antibacterial ya, Cubicin maka ọgwụgwọ endocarditis obi ziri ezi nke Staphylococcus aureus na-efe efe na-akpata na akpụkpọ ahụ gbagwojuru anya na ọrịa anụ ahụ dị nro metụtara ọrịa Staphylococcus aureus kpatara.