Daptomycin CAS 103060-53-3 Ịdị Ọcha ≥95.0% API Ụlọ Ọrụ Dị Ọcha Dị Elu
Onye nrụpụta nwere ịdị ọcha dị elu yana ogo kwụsiri ike
Aha ọgwụ: Daptomycin
Nọmba: 103060-53-3
API Ogo dị elu, mmepụta azụmahịa
Aha Chemical | Daptomycin |
Ụdị okwu | LY146032 |
Nọmba CAS | 103060-53-3 |
Nọmba CAT | RF-API10 |
Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
Usoro ihe omimi | C72H101N17O26 |
Ibu molekụla | 1620.69 |
Ebe Na-agbaze | 202.0-204.0 ℃ |
Solubility | Solube na methanol |
Ụdị | Ruifu Chemical |
Ihe | Nkọwapụta |
Ọdịdị | Acha odo odo ma ọ bụ Pale Yellow Powder |
njirimara HPLC | Oge njide nke isi kacha elu nke ngwọta nlele kwesịrị ikwekọ na nke ọkọlọtọ ntụaka. |
njirimara IR | Ụdị ụdịdị IR nke ụdị ule kwesịrị ikwekọ n'ụkpụrụ ntụaka IR. |
Ọdịdị nke Ngwọta | Idozi Ngwọta ahụ kwesịrị ịpụta nke ọma ma ọ bụ na-ekwupụtaghị karịa nke nkwusioru ntụaka II. |
Ntụgharị ngwa anya akọwapụtara | +17.0° ruo +25.0° |
pH | 4.0 ruo 5.0 |
Ihe fọdụrụ na mgbanye | ≤1.0% |
Anhydro-Daptomycin | ≤2.5% |
β-Isomer | ≤0.50% |
Hydrolysis adịghị ọcha | ≤0.50% |
adịghị ọcha 1 | ≤0.75% |
adịghị ọcha 2 | ≤0.75% |
adịghị ọcha 3 | ≤0.75% |
Ọdịghị ọcha ọ bụla ọzọ | ≤0.15% |
Mgbakọta adịghị ọcha | ≤5.0% |
Ọla dị arọ | ≤30ppm |
Mmiri | ≤5.0% |
Ịdị ọcha | ≥95.0% (gbakọọ na nke a mịrị amị) |
Endotoxins nke nje bacteria | <0.3EU/mg |
Residual Solvents n-Butanol | ≤5000ppm |
ResidualSolvents isopropanol | ≤5000ppm |
Ethanol fọdụrụnụ | ≤5000ppm |
Oke Microbial TAMC | ≤100cfu/g |
Oke Microbial TYMC | ≤10cfu/g |
E.Coil | Achọpụtaghị |
Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
Ọnọdụ Nchekwa | Chekwaa n'ime akpa siri ike, ma chekwaa na -25 ~ -10 ℃. |
Ojiji | Ngwakọta ọgwụ na-arụ ọrụ (API) |
ngwugwu: Kalama, Aluminom foil bag, kaadiboodu drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.
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Daptomycin (CAS: 103060-53-3) bụ ụdị ọgwụ nje lipopeptide cyclic nwere usoro ọhụụ.A na-ewepụta ya na broth Streptomyces gbaa ụka.Ụlọ ọrụ Eli Lilly chọtara ya na 1980, wee mepụta nke ọma na 1997 site na Cubist Pharmaceuticals.Ọ bụghị naanị na ọ nwere usoro kemịkalụ ọhụụ mana ọ nwekwara usoro omume nke dị iche na ọgwụ nje ọ bụla akwadoro na mbụ: ọ na-egbochi cell site na imebi ibufe amino acid site na akpụkpọ ahụ, si otú a na-egbochi mgbidi cell peptidoglycan biosynthesis na ịgbanwe ọdịdị nke akpụkpọ ahụ cell.Ọ nwere ike imebi akpụkpọ ahụ sel nke nje bacteria n'ọtụtụ akụkụ, wee gbuo nje bacteria na-adị mma ngwa ngwa.Na mgbakwunye na ọrụ nke na-emetụta ọtụtụ nje bacteria na-emetụta gram-positive, nke ka mkpa, Daptomycin nwere mmetụta dị ike n'ịgwọ ụdị dịpụrụ adịpụ nke gosipụtara ihe ịrịba ama nke iguzogide methicillin, vancomycin na linezolid.Ihe onwunwe a bara ezigbo uru maka ndị ọrịa na-arịa ọrịa siri ike.Na Septemba 2003, nchịkwa nri na ọgwụ ọjọọ nke United States kwadoro na nke mbụ na Daptomycin (CAS: 103060-53-3) nwere ike itinye maka ọgwụgwọ nke ọrịa akpụkpọ anụ siri ike.Na March 2006, a kwadoro ya maka ịgwọ ọrịa na-efe efe.Na Jenụwarị 2006, European Commission kwadoro ya maka ọgwụgwọ ụfọdụ akpụkpọ anụ na anụ ahụ dị nro nke nje bacteria gram-positive kpatara.Na Septemba 6, 2007, Cubist Pharmaceuticals kwupụtara na European Union akwadola ọgwụ nje antibacterial ya, Cubicin maka ọgwụgwọ endocarditis obi ziri ezi nke Staphylococcus aureus na-efe efe na-akpata na akpụkpọ ahụ gbagwojuru anya na ọrịa anụ ahụ dị nro metụtara ọrịa Staphylococcus aureus kpatara.
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