Darunavir CAS 206361-99-1 Anti-HIV ịdị ọcha ≥99.0% API Ihe mgbochi mgbochi nje HIV dị elu
Onye nrụpụtaNgwa ndị metụtara Darunavir:
Darunavir CAS 206361-99-1
Darunavir Ethanolate CAS 635728-49-3
(2S,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98737-29-2
(2R,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98760-08-8
(3S)-3-(tert-Butoxycarbonyl)amino-1-Chloro-4-Phenyl-2-Butanone CAS 102123-74-0
Aha Chemical | Daunavir |
Ụdị okwu | TMC114;UIC-94017 |
Nọmba CAS | 206361-99-1 |
Nọmba CAT | RF-API68 |
Ọnọdụ Ahịa | Na Akụrụngwa, Mpụta Ihe ruru narị narị kilograms |
Usoro ihe omimi | C27H37N3O7S |
Ibu molekụla | 547.66 |
Ụdị | Ruifu Chemical |
Ihe | Nkọwapụta |
Ọdịdị | Ntụ ntụ kristal na-acha ọcha ma ọ bụ gbanyụọ |
njirimara | MS/HNMR HPLC |
Solubility | Soluble na DMSO, Na-agbaze Na Mmiri |
Ebe Na-agbaze | 74.0 ~ 76.0 ℃ |
njirimara | 1H NMR |
Ụzọ ịdị ọcha / nyocha | ≥99.0% (HPLC) |
Ihe ndị emetụtara | |
Oke Otu adịghị ọcha | ≤0.30% |
Mgbakọta adịghị ọcha | ≤1.0% |
Ihe mgbaze fọdụrụnụ | Ethanol ≤0.30% |
Ọnwụ na ihicha | ≤0.50% |
Ihe fọdụrụ na mgbanye | ≤0.10% |
Ọla dị arọ | ≤20ppm |
Arsenic | ≤1.5pm |
Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
Ojiji | Darunavir (CAS 206361-99-1) HIV-1 Protease Inhibitor Anti-HIV |
ngwugwu: Kalama, Aluminom foil bag, Cardboard Drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.
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Darunavir (aha aha Prezista, nke a na-akpọbu TMC114) bụ ọgwụ mgbochi protease eji agwọ nje HIV.Darunavir bụ nhọrọ ọgwụgwọ OARAC akwadoro maka ọgwụgwọ-enweghị uche na ọgwụgwọ nwere ahụmahụ na ndị okenye na ndị nọ n'afọ iri na ụma.Darunavir bụ ụdị ọhụrụ na-abụghị peptide anti retroviral protease inhibitors na ọgwụgwọ AIDS.Nke izizi ya bụ alaka ụlọ ọrụ na-ahụ maka ọgwụ Johnson nke Iceland, Tibotec.Ọ bụ nke kachasị elu bioavailability na 6 protease inhibitors (saquinavir, ritonavirvir, indinavir, naphthalene nelfinavir, amprenavir na ABT378/r).Ọ na-eme ihe site n'igbochi irighiri nje virus ọhụrụ ma tozuru oke site n'elu sel ndị butere ọrịa na igbochi protease nke nje.Mgbe a na-eji ngwaahịa a ogologo oge, ọ na-enwekarị ike ibelata vector nje HIV n'ime ọbara, mee ka ọnụ ọgụgụ nke sel CD4 dịkwuo elu, belata ohere nke nje HIV, meziwanye ndụ ndụ na ogologo ndụ.Ọ dị mma maka ndị toro eto bu nje HIV mana enweghị mmetụta ọ bụla n'iji ọgwụ antiretroviral dị adị.A ghaghị ijikọta ọgwụ ahụ na iji obere doses nke ritonavir ma ọ bụ ihe ndị ọzọ na-egbochi ọrịa retroviral, iji mee ka ọ dị mma.Enwere ike nyochaa ọrụ mgbochi na vitro site na imegide lymphocytes na-arịa ọrịa na-adịghị ala ala na lymphocytes n'ime ọbara dị n'akụkụ.