Darunavir Ethanolate CAS 635728-49-3 Ịdị Ọcha ≥99.0% API Ụlọ ọrụ na-egbochi nje HIV.
Ngwaahịa ndị emetụtara Darunavir onye nrụpụta:
Darunavir CAS 206361-99-1
Darunavir Ethanolate CAS 635728-49-3
(2S,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98737-29-2
(2R,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98760-08-8
(3S)-3-(tert-Butoxycarbonyl)amino-1-Chloro-4-Phenyl-2-Butanone CAS 102123-74-0
| Aha Chemical | Darunavir Ethanolate |
| Ụdị okwu | DRV;Prezista;TMC114 Ethanolate;UNII-33O78XF0BW;N-[(1S,2R) -3-[(4-Aminophenyl) sulfonyl] (2-methylpropyl) amino] -2-hydroxy-1- (phenylmethyl) propyl] carbamic acid (3R,3aS,6aR) -hexahydrofur [2,3-b]furan-3-yl ester compd.na ethanol |
| Nọmba CAS | 635728-49-3 |
| Nọmba CAT | RF-API69 |
| Ọnọdụ Ahịa | Na Akụrụngwa, Mpụta Ihe ruru narị narị kilograms |
| Usoro ihe omimi | C29H43N3O8S |
| Ibu molekụla | 593.73 |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta |
| Ọdịdị | Ntụ ntụ kristal na-acha ọcha ma ọ bụ gbanyụọ |
| njirimara IR | Dakọtara na Standard Spectrum |
| Ntụgharị akọwapụtara | -0.5°~ +0.5° |
| Ihe ndị emetụtara | (nke HPLC) |
| Oke Otu adịghị ọcha | ≤0.20% |
| Mgbakọta adịghị ọcha | ≤0.50% |
| Mmiri (KF) | ≤1.0% |
| Ihe fọdụrụ na mgbanye | ≤0.10% |
| Ọla dị arọ | ≤10ppm |
| Ọdịnaya nke ethanol | ≤7.5% (GC) |
| Ihe mgbaze fọdụrụnụ | Methanol ≤0.30% |
| Ịdị ọcha | ≥99.0% (HPLC) |
| Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
| Ojiji | Darunavir Ethanolate HIV-1 Protease Inhibitor Anti-HIV Antiviral |
ngwugwu: Kalama, Aluminom foil bag, Cardboard Drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.
Darunavir Ethanolate (Prezista) bụ onye na-egbochi nje HIV.Ihe sitere na Darunavir, ọgbọ nke abụọ nke nje HIV-1-protease inhibitor;N'usoro yiri amprenavir.Antiviral.Ọ bụ ngwaahịa nyocha COVID19 metụtara.N'ụzọ dị mwute, DRV nwere obere solubility na mmiri na adịghị mma bioavailability, ya mere, ọ na-achọ nchịkwa na dịtụ elu doses iji gosi irè ọgwụgwọ.Darunavir bụ ihe mgbochi nwere ike sara mbara nke na-arụ ọrụ megide njepụ ụlọ ọgwụ HIV-1 nwere obere cytotoxicity.Darunavir na-emepụta njikọ hydrogen na atom ndị bụ isi nke Asp29 na Asp30 nke protease echekwara.A na-atụ aro ka mmekọrịta ndị a dị oke egwu maka ike nke ogige a megide nje HIV na-eguzogide ọtụtụ ihe mgbochi protease.N'ime nyocha in vitro na mkpụrụ ndụ MT-2, ike darunavir dị ukwuu karịa nke saquinavir, amprenavir, nelfinavir, indinavir, lopinavir na ritonavir.Darunavir bụ isi metabolized site na imeju cytochrome P450 (CYP) enzymes, bụ isi CYP3A.Usoro 'nkwalite' nke ritonavir na-eme ihe mgbochi nke CYP3A, si otú ahụ na-abawanye bioavailability darunavir.Emebere Darunavir ka ọ bụrụ mmekọrịta siri ike na protease enzyme sitere na ọtụtụ ụdị nje HIV, gụnyere nsogbu sitere na ndị ọrịa nwere ahụmahụ ọgwụgwọ nwere ọtụtụ nguzogide mutati.
