Decitabine CAS 2353-33-5 Dị Ọcha> Ụlọ ọrụ 99.5% (HPLC)
Shanghai Ruifu Chemical Co., Ltd bụ onye na-emepụta ihe na onye na-ebubata Decitabine (CAS: 2353-33-5) nwere àgwà dị elu.Anyị nwere ike ịnye COA, nnyefe zuru ụwa ọnụ, obere na nnukwu ọnụọgụ dị.Ọ bụrụ na ị nwere mmasị na ngwaahịa a, biko ziga ozi zuru ezu gụnyere nọmba CAS, aha ngwaahịa, ọnụ ọgụgụ anyị.Please contact: alvin@ruifuchem.com
| Aha Chemical | Decitabine |
| Ụdị okwu | 5-Aza-2'-Deoxycytidine;5-Aza-1- (2-Deoxy-β-D-Ribofuranosyl) cytosine;5-Aza-CdR;5-Aza-dC;5-Deoxy-2'-Azacytidine;ZdCyd;DAC;β-Decitabine |
| Nọmba CAS | 2353-33-5 |
| Nọmba CAT | RF2728 |
| Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
| Usoro ihe omimi | C8H12N4O4 |
| Ibu molekụla | 228.21 |
| Ebe Na-agbaze | 191 ℃ (Dec.) |
| Mmetụta | Mmetụta ikuku, Mmetụta okpomọkụ |
| Solubility | Agbasara na DMSO;Dị ntakịrị Soluble na Mmiri |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta |
| Ọdịdị | Ntụ ntụ kristal na-acha ọcha ma ọ bụ gbanyụọ |
| njirimara A | IR: Sample IR Spectrum kwekọrọ na nke ọkọlọtọ |
| njirimara B | HPLC: RT nke Isi Peak nke Ngwọta Nnwale kwekọrọ na nke Ngwọta Ọkọlọtọ |
| njirimara C | PXRD: Ọ dị mma |
| Ụzọ ịdị ọcha / nyocha | > 99.5% (HPLC) |
| Alfa | +56.0°~ 63.0° |
| Ọnwụ na ihicha | <0.50% |
| Ihe fọdụrụ na mgbanye | <0.10% |
| Ọla dị arọ | <20ppm |
| Ihe ndị emetụtara | |
| α-Decitabine | <0.20% |
| Otu adịghị ọcha amaghi ama | <0.20% |
| Mgbakọta adịghị ọcha | <0.50% |
| Ihe mgbaze fọdụrụnụ | |
| DMSO | <0.50% |
| Methanol | <0.30% |
| Methyl Formate | <0.05% |
| Acetonitrile | <0.041% |
| Solubility | Kpochapụ 50 mg/ml enweghị agba, HOAc na H2O (1:1) gafere |
| Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
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Nyocha ụlọ ọrụ?Nnabata nyocha ụlọ ọrụ.Biko mee oge oge tupu oge eruo.
MOQ?Enweghị MOQ.A na-anabata obere usoro.
Oge Mbuga ozi? Ọ bụrụ n'ime ngwaahịa, ekwenyere nnyefe ụbọchị atọ.
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Synthesis omenala?Nwere ike ịnye ọrụ nhazi ahaziri iche ka ọ dabara mkpa nyocha gị nke ọma.
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Decitabine (CAS: 2353-33-5) (aha ahia Dacogen), ma ọ bụ 5-Aza-2'-Deoxycytidine.Kemịkalụ, ọ bụ analọg cytidine.Decitabine bụ ọgwụ hypomethylating.Emebela decitabine maka ọgwụgwọ myelodysplastic syndromes (MDS).MDS bụ usoro ọrịa hematologic na-emetụta ụmị ọkpụkpụ nke na-eme ka e guzobe na mmepe nke mkpụrụ ndụ ọbara adịghị arụ ọrụ.Ọzọkwa, ndị ọrịa nwere MDS nwere nnukwu ihe ize ndụ nke ịga n'ihu ruo nnukwu myeloid leukemia (AML).Ọgwụgwọ ọdịnala na-agụnye mmịnye ọbara, ihe na-eto eto hematopoietic, na ọgwụ nje ndị na-egbochi ọrịa, ma usoro ndị a na-eme ka ndụ dịkwuo mma na-enwe mmetụta na-enyo enyo na mgbanwe ọrịa.Ọ bụ ezie na ntụgharị mkpụrụ ndụ stem-cell bụ ụzọ ike ike, nke nwere ike ịgwọ ọrịa, afọ ime agadi ma ọ bụ nsogbu ahụike ndị ọzọ na-agbagwoju anya nke ọtụtụ ndị ọrịa na-egbochi ha ịtụle nhọrọ a.Ọganihu n'oge na-adịbeghị anya na etiology dị n'okpuru nke MDS, Otú ọ dị, emewo ka ịmepụta klas ọhụrụ nke ogige a maara dị ka '' demethylating agents ''.Decitabine na-esochi mmeghe nke ọma nke mbụ DNA methyltransferase inhibitor Azacitidine.Ọ hypomethylates DNA site na igbochi DNA methyltransferase.Ọ na-arụ ọrụ n'otu aka ahụ na Azacitidine, ọ bụ ezie na decitabine nwere ike ịbanye na DNA strands ebe azacitidine nwere ike itinye n'ime DNA na RNA abụọ.Reagents nyocha: A na-eji Decitabine eme ihe n'ọtụtụ ebe na bayoloji molecular, ọgwụ ọgwụ na nyocha sayensị ndị ọzọ.Decitabine dị ka onye na-emechi DNA methyltransferase kpọmkwem, usoro DNA methylation nke na-agbanwe agbanwe, na-ebute mkpụrụ ndụ tumo na sel nkịtị iji chọpụta ma ọ bụ mee ka apoptosis cell tumor.Jiri nwayọ rịba ama na nnukwu mkpokọta nke Decitabine ga-arụ ọrụ cytotoxic ya: nwere ike igbochi njikọ DNA kpatara ọnwụ cell.
