Desmopressin Acetate CAS 16789-98-3 Peptide Purity (HPLC) ≥98.5% Ụlọ ọrụ

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Desmopressin Acetate (CAS: 16789-98-3) ya bụ, 1-cysteine ​​​​deamination na 8-D-arginine kama 8-l-arginine, nke a makwaara dị ka arginine vasopressin, bụ ihe analog na-emepụta ihe nke arginine vasopressin, ihe sitere na ya. vasopressin, mmetụta antidiuretic ya dị ike ma na-adịgide adịgide karịa vasopressin, mana ọ nweghị mmetụta vasoconstrictor, mmetụta dị n'akụkụ ọgwụ, ụlọ ọgwụ maka ọmụmụ ma ọ bụ ọgwụ na-akpata platelet dysfunction, uremia, imeju imeju na amaghị ihe kpatara ya site na ogologo oge ọbara ọgbụgba;Enwere ike ijikwa ma gbochie ọbara ọgbụgba n'oge obere ịwa ahụ;Central ọrịa shuga insipidus.N'ọnọdụ ndị mmadụ n'otu n'otu, ngwaahịa a ga-arụpụta nrụpụta ọrụ na ndị ọrịa nwere ọrịa sistemu urinary na-agafeghị oke, na-enwekarị nkwarụ na ndị ọrịa nwere ụdị IIB von Willebrand ọrịa.
Omume ọgwụ: Desmopressin Acetate nwere desmopressin nke dị ka arginine vasopressin nke ala.Ọ bụ ihe dị iche n'etiti arginine vasopressin, tumadi maka ọkara nke amino acid na D arginine dochie L Arginine.Mgbanwe nhazi ndị a na-agbatị ogologo oge ọrụ nke ọgwụ desmopressin na-enweghị mmetụta nke mkpakọ.Ụfọdụ ọmụmụ egosila na mmetụta nke antienuresis dị ịrịba ama, nke nwere ike ịbụ n'ihi mmụba nke arginine vasopressin n'ọbara ụmụaka n'abalị, na mgbe ahụ na-etinye uche na mmamịrị, belata mmamịrị olu na intravascular mgbali, ibelata olu na nkwekọrịta detrusor.
Ọdịmma ya, ịdị mfe nchịkwa (intranasal), ogologo oge ọ na-arụ ọrụ na enweghị mmetụta na-eme ka ọ bụrụ ọgwụ nhọrọ maka ọgwụgwọ nke ọrịa shuga etiti etiti.Enwere ike inye ya intramuscularly orintravenously.A na-ahọrọ vasopressin injection na antidiuretics nke ọnụ maka iji ụmụaka mee ihe.A na-egosi njikwa nke polydipsia nwa oge yana polyurias jikọtara ya na trauma na, ma ọ bụ ịwa ahụ na mpaghara pituitary.
Iji ụlọ ọgwụ: Desmopressin, dị ka nnu acetate ya, bụ analog synthetic nke vasopressin nke N njedebe Cys enweghị ọrụ α-amino (1-Deamino) na ebe Arg8 dị ka D-isomer (D-Arg8) , yabụ okwu mkpọ okwu azụmahịa DDAVP.Ọnụnọ nke D-Arg na enweghị N-terminal amine na desmopressin Ọdịdị emeela ka ọkara ndụ ya dị ka ọ dị maka ọnụ, parenteral, ma ọ bụ imi.A na-eji ya niile ụzọ atọ ndị a nke nchịkwa iji gbochie ma ọ bụ chịkwaa polydipsia (oke akpịrị ịkpọ nkụ), polyuria, na akpịrị ịkpọ nkụ nke ndị ọrịa nwere ọrịa shuga insipidus nke ụkọ vasopressin kpatara.A kwadokwara ya maka ọgwụgwọ nke enuresis nocturnal (bed-wetting), nke a kwenyere na ọ bụ ihe kpatara ya site na enweghị mmụba nke oge abalị nkịtị na ọkwa vasopressin.A maara Desmopressin ka ọ na-eme ka mmụba nke abụọ plasma factor VIII (antihemophilic factor) na plasminogen activator.Ya mere, US FDA kwadoro ya maka ojiji, nne na nna na imi, n'ibelata ọbara ọgbụgba na mberede ma ọ bụ trauma kpatara na ndị ọrịa nwere ọrịa hemophilia A na ụdị I Von Willebrand ọrịa, ma ọ bụrụhaala na ọrụ plasma ihe VIII ha karịrị 5%.Stimate, imi imi nke a na-eji na-agwọ ndị ọrịa nwere hemophilia A na ụdị ọrịa Von Willebrand nke mbụ, bụ okpukpu iri na ise nke DDAVP imi imi;A na-eji nke ikpeazụ agwọ ọrịa insipidus ọrịa shuga.