Diethylphosphonoacetic Acid CAS 3095-95-2 Dị Ọcha>99.5% (HPLC) Afatinib Dimaleate Intermediate Factory egosipụtara

Diethylphosphonoacetic Acid CAS 3095-95-2 Ịdị Ọcha>99.5% (HPLC) Afatinib Dimaleate Ụlọ ọrụ etiti

Nkọwa dị mkpirikpi:

Aha kemịkal: Diethylphosphonoacetic acid

CAS: 3095-95-2

Dị ọcha:> 99.5% (HPLC)

Ọdịdị: Liquid enweghị agba

Nke etiti Afatinib Dimaleate (CAS: 850140-73-7)

Ogo dị elu, mmepụta azụmahịa

E-Mail: alvin@ruifuchem.com

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Nkọwa:

Ruifu Chemical Supply Intermediates of Afatinib
Afatirib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino) acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H) -otu CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S) -N4- (3-Chloro-4-Fluorophenyl) -7-((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N- (3-Chloro-4-Fluorophenyl) -6-Nitro-7-((Tetrahydrofuran-3-yl) oxy) quinazolin-4-AmineCAS 314771-88-5

Njirimara kemịkalụ:

Aha Chemical	Diethylphosphonoacetic acid
Ụdị okwu	2- (Diethoxyphosphosphoryl) acetic acid;(Diethoxyphosphinyl) acetic acid;Diethyl Carboxymethylphosphonate;NSC 272281
Nọmba CAS	3095-95-2
Nọmba CAT	RF-PI2024
Ọnọdụ Ahịa	N'ahịa, Ikike Mmepụta 30MT/ọnwa
Usoro ihe omimi	(C2H5O) 2P (O) CH2CO2H
Ibu molekụla	196.14
Ebe esi nri	150 ℃/0.05 mmHg (ọkụ)
Njupụta	1.220 g / ml na 25 ℃ (ọkụ)
Ntụgharị uche	n20/D 1.445 (ọkụ)
Ụdị	Ruifu Chemical

Nkọwapụta:

Ihe	Nkọwapụta
Ọdịdị	Mmiri na-enweghị agba
njirimara (HPLC)	Oge njide nke isi kachasị elu nke enwetara site na nlele ahụ dị n'ime 5% nke ihe nlele.
Ụzọ ịdị ọcha / nyocha	> 99.5% (HPLC)
Spectrum infrared	Dabara na Ọdịdị
Ọnụ ego nke Proton NMR Spectrum	Dabara na Ọdịdị
Mmiri (KF)	<0.50%
Mgbakọta adịghị ọcha	<0.50%
Nlele ọkọlọtọ	Standardkpụrụ ụlọ ọrụ
Ojiji	Nke etiti Afatinib Dimaleate (CAS: 850140-73-7)

Ngwungwu & Nchekwa:

ngwugwu: Fluorinated karama, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ

Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri

Uru:

Ajụjụ:

Ngwa:

Diethylphosphonoacetic acid (CAS: 3095-95-2), Ọrụ dị ka nucleophile maka nucleophilic mgbakwunye mmeghachi omume maka njikọ nke allene epoxides Reactant maka: stereoselectivity ọmụmụ nke Staudinger mmeghachi omume;Enantioselective guzobe nke diols site epioxidation na hydration mmeghachi omume;Mmeghachi omume Horner-Wadsworth-Emmons;Chelation dịpụrụ adịpụ na-achịkwa Ireland-Claisen nhazigharị;Ugi-Dieckmann mmeghachi omume maka njikọ nke tetramic acid mmepụta;A na-eji eme etiti phosphonoester maka mmeghachi omume HEW intramolecular.Diethylphosphonoacetic acid bụ etiti nke Afatinib Dimaleate (CAS: 850140-73-7).Ndị na-ahụ maka nri na ọgwụ ọjọọ nke US (FDA) kwadoro Afatinib Dimaleate na 2013 maka ọgwụgwọ ọrịa cancer akpa ume na-abụghị obere cell (NSCLC).Kpọmkwem, akwadoro ya maka ndị ọrịa na-egosi etuto NSCLC metastatic nke nwere mkpochapụ nke ihe na-akpata uto epidermal (EGFR) ma ọ bụ mmụgharị exon 21.Afatinib Dimaleate bụ covalent inhibitor nke ErbB tyrosine kinases (tyk), nke na-emebi akara ErbB site na ijikọ saịtị EGFR tyk na-enweghị ike ịgbanwe.