Diflorasone Diacetate CAS 33564-31-7 Assay 97.0 ~ 103.0% Corticosteroid Factory

Diflorasone Diacetate (33564-31-7)
» Diflorasone Diacetate nwere ọ bụghị ihe na-erughị 97.0 pasent na ọ bụghị karịa 103.0 pasent nke C26H32F2O7, gbakọọ na a mịrị amị ndabere.
Nkwakọ ngwaahịa na nchekwa - Chekwaa n'ime akpa siri ike.
Ụkpụrụ ntụaka USP <11>-
USP Diflorasone Diacetate RS
Nchọpụta, Infrared Absorption <197M>.
Ntụgharị a kapịrị ọnụ <781S>: n'etiti +58° na +68°.Ngwọta ule: 20 mg, amịghị mkpụrụ, kwa ml, na chloroform.
Ọnwụ na ihicha <731>-Kọchaa ya na agụụ na 60 Celsius na nrụgide na-erughị 5 mm nke mer cury maka awa 16: ọ na-efunahụ karịa 0,5% nke ibu ya.
Ihe fọdụrụ na mgbanye <281>: ọ bụghị karịa 0.5%
Chromatographic ịdị ọcha-
Usoro mkpanaaka na usoro Chromatographic- Kwadebe dị ka a gwara ya na nyocha.
Ngwọta nwale-gbarisịa ọnụọgụ Diflorasone Diacetate a tụrụ n'ụzọ ziri ezi na chloroform nke mmiri juputara iji nweta ihe ngwọta nwere mkpokọta ihe dịka 6 mg kwa ml.
Usoro-Tinye otu olu (ihe dị ka 10 µL) nke ngwọta Nnwale n'ime chromatograph, dekọọ chromatogram maka oge nhata ugboro 5 n'oge njigide nke isi kacha elu, wee tụọ akụkụ nke ọnụ ọnụ niile.Gbakọọ pasent nke adịghị ọcha ọ bụla na akụkụ nke Diflorasone Diacetate nke usoro a were were:
100 (ri / rs)
nke ri bụ ebe kacha elu maka adịghị ọcha ọ bụla;na rs bụ nchikota nke mpaghara niile nke elu: ọ bụghị ihe karịrị 1.0% nke onye ọ bụla adịghị ọcha na-achọta;na ọ bụghị ihe karịrị 2.0% nke mkpokọta adịghị achọta.
Nyocha -
Usoro mkpanaaka- Kwadebe ihe ngwọta nwere ngwakọta nke mmiri n-butyl chloride, methylene chloride jupụtara na mmiri, glacial acetic acid, na tetrahydrofuran (350:125:15:10).Mee mgbanwe ma ọ bụrụ na ọ dị mkpa (lee Dabara Sistemu n'okpuru Chromatography <621>).
Ihe ngwọta dị n'ime - Iji chloroform juputara na mmiri, kwadebe ihe ngwọta nke isoflupredone acetate nwere ihe dịka 0.04 mg kwa ml.
Nkwadebe Ọkọlọtọ-Kwụsa ọnụ ọgụgụ USP Diflorasone Diacetate RS nke a tụrụ n'ụzọ ziri ezi na ngwọta dị n'ime ime iji nweta ihe ngwọta nwere njiri mara nke ihe dị ka 33µg kwa ml.
Nkwadebe nyocha- Nyefee ihe dịka 15 mg nke Diflorasone Diacetate, nke a tụrụ nke ọma, gaa na flask volumetric 500-mL.Tinye ihe ngwọta dị n'ime na olu, ma gwakọta ya.
Usoro Chromatographic (lee Chromatography <621>) -Kromatograph mmiri mmiri nwere ihe nchọta 254-nm yana kọlụm 4.6mm × 10-cm nke nwere 3-µm mbukota L3.Onu ogugu a bu ihe dika 2.5 ml kwa nkeji.Chromatograph the Standard nkwadebe, na dekọọ ọnụ ọgụgụ kasị elu dị ka eduzi maka Usoro: mkpebi, R, n'etiti nyocha na n'ime ọkọlọtọ ọnụ ọgụgụ kasị elu erughị 12;na ndị ikwu ọkọlọtọ ndiiche maka ọ bụghị ihe na-erughị anọ oyiri injections abụghị ihe karịrị 2.0%.
Usoro-iche iche nha nha nha (ihe dị ka 10 µL) nke nkwadebe ọkọlọtọ na nkwadebe Assay n'ime chromatograph, dekọọ chromatograms, wee tụọ mpaghara maka ọnụ ọgụgụ ndị bụ isi.Oge njide ikwu ihe dị ka 1.0 maka diflorasone diacetate yana 2.4 maka ọkọlọtọ ime.Gbakọọ ọnụọgụ, na mg, nke C 26H32F2O7 n'akụkụ nke Diflorasone Diacetate nke usoro a bu:
0.5C (RU / RS)
nke C bụ ntinye uche, na µg kwa ml, nke USP Diflorasone Diacetate RS na nkwadebe ọkọlọtọ;na RU na RS bụ oke nke mpaghara kachasị elu maka Diflorasone Diacetate na mpaghara ọkọlọtọ dị n'ime nke enwetara site na nkwadebe Assay na Standard nkwadebe, n'otu n'otu.