DMF-DMA CAS 4637-24-5 N,N-Dimethylformamide Dimethyl Acetal Dị Ọcha>99.0% (GC) Ụlọ Ọrụ Na-ekpo ọkụ

Ebe Meenvin kọrọ nkwadebe nke DMF-DMA (N, N-Dimethylformamide Dimethyl Acetal) na 1956, DMF-DMA aghọwo reagent na-ejikarị eme ihe na njikọ organic.
A na-eji DMF-DMA eme ihe n'ọtụtụ ebe n'iwu mgbanaka heterocyclic ise ma ọ bụ isii nwere na mmeghachi omume mmechi mgbanaka.DMF-DMA nwere mmeghachi omume dị nro na mkpụrụ dị elu, karịsịa maka ogige ndị na-eguzogide elu.
Usoro izugbe nke ogige amide acetal bụ nke a:
Ihe a na-ejikarị eme ihe bụ DMF-DMA na DMF-DEA, amide acetal na-adị mfe hydrolyzed, nwere ike esterified, amidine, alkylation na cyclization mmeghachi omume.
Atọm carbon etiti nke DMF-DMA jikọtara ya na heteroatoms atọ nwere nnukwu electronegative, nke na-eme ka ọ nwee ọrụ electrophilic siri ike.N'okpuru ọrụ nke acid, otu alkoxy dị mfe ịhapụ, a na-enwetakwa ion dị mma na ọrụ electrophilic siri ike.Mmeghachi omume nke DMF-DMA tumadi bụ mmeghachi omume methylation na mmeghachi omume nguzobe.
"Otu-carbon Syntheson" nke DMF-DMA
Na mmeghachi omume mmechi nke akaghị aka nke metụtara DMF-DMA, naanị otu carbon atom dị na ngwaahịa a bụ DMF-DMA na-enyekarị ya, yabụ enwere ike were DMF-DMA dịka njikọ carbon.
Mmeghachi omume esterification DMF-DMA
DMF-DMA esterification na-enyere dị iche iche carboxylic acids mfe n'ịwa C1-20 alkyl ma ọ bụ aryl esters, na byproducts nwere ike mfe ikewa site distillation.
Adipic acid na DMF-DMA bụ nke esterified na 80 degrees maka awa abụọ.Amide acetal bụ ezigbo nhọrọ maka ibelata ụfọdụ acid carboxylic nwere ihe mgbochi siri ike ma ọ bụ nkwụsi ike na-adịghị mma.
Mmeghachi omume nke DMF-DMA amidination na nchebe nke ndị isi amines
Amide acetals nwere ike ime ọ bụghị naanị na amines bụ isi, kamakwa na amides, carbamate, sulfonamides iji mepụta njikọ nke hydrocarbon.
Dị ka: 2, 4-dimethyl aniline na DMF-DMA na ogo 80 nwere ike wepụ methanol ngwa ngwa iji mepụta ogige dimethamidine.
DMF-DMA nwekwara ike iji dị ka ndị isi amine nchebe otu, isi amine nchebe otu (2 NH niile nchebe) eleghị anya ọtụtụ ndị na-eche banyere phthalyl, pyrrole mgbanaka, Double Boc, double PMB, wdg, ma DMF-DMA nchebe nke isi. amine, n'ọnọdụ ụfọdụ dịkwa oke uru nchedo atụmatụ, gbanyụọ nchebe naanị chọrọ TFA ngwakọta.
Nchedo Amino - 13 isi mmalite nchebe nkịtị, ahụmịhe nhọrọ ntọala nchekwa, oke ojiji, ọnọdụ mmeghe, ọnọdụ mwepụ nke nchịkọta nchịkọta
DMF-DMA na-emeghachi omume na otu methyl na methylene na-arụ ọrụ iji mepụta njikọ abụọ nke carbon-carbon
Phenylmethylation nke DMF-DMA
Mmeghachi omume ngwakọta heterocyclic na DMF-DMA
Enwere ike iji Amide acetal dị ka otu onye na-enye carbon iji mepụta ogige dị mgbagwoju anya na ihe okike biomimetic.Na amide acetals nwere ike synthesized: 1,2.4 triazole, 1.2, 4 triazolone, aminoheterocyclic mmepụta, pyrimidine, pyrimidine, indoles, pyridine, quinoline, thiazole, oxazolone, isooxazole, 1.2, 4-triazone, pyrazine, pyrazine na ndị ọzọ. nke amonia heterocyclic derivatives, nwekwara ike synthesized oxygen, sọlfọ heterocyclic ogige.
Dị ka ụdị mmeghachi omume kemịkalụ si dị, ntinye nke amide acetal na njikọ nke heterocyclic nwere ike kewaa n'ime akụkụ atọ ndị a.
(1): amide acetal na amine, amide, mmeghachi omume lipid carbamate, na-emepụta mgbanaka heterocyclic dị iche iche.
Amidoacetal na amine mmeghachi omume na foramidine intermediate, na mgbe ahụ intramolecular nucleophilic mgbanaka mmeghachi omume n'ịwa dị iche iche heterocycles, ma ọ bụ formamidine na hydrazine, hydroxylamine, l, 2, otu ma ọ bụ abụọ alkyl halides nwere abụọ na-arụsi ọrụ ike ìgwè nke ogige gbakwunyere ogologo carbon yinye, na mgbe ahụ intramolecular mgbanaka. .
Njikọ nke ogige heterocyclic site na mmeghachi omume nke amide acetals na amides, dị ka njikọ nke l, 2,4 monotriazole.Nke mbụ, acetal na-emeghachi omume na amide ka ọ mepụta N, N 'tritradil, wee jiri phenylhydrazine mee mgbanaka iji mepụta l, 2,4 monotriazole.
Amide acetals na-emeghachi omume na carbamic acid ma ọ bụ acetate iji mepụta mgbanaka heterocyclic nwere chlorine.Ọkpụkpọ okwu nke etolite site na mmeghachi omume nke amide acetal nwere aminoethyl ester: nn-dimethyl-n 'alkyl-carboxymethyl formamidine, nke na-emeghachi omume na hydrazine ma ọ bụ hydrazine dochie anya.Dịka ọmụmaatụ, maka nkwadebe nke 1,2,4 triazinone-6, e gosipụtara nha nha n'okpuru.Ọ bụrụ na ị meghachi omume ya na nitro-formate ị ga-enweta 1,2,4 triazolone-5.
Usoro mmeghachi omume maka nhazi nke 1,2,4 triazolone-5
Ngwakọta nke 1.2.4-triazolidin-5 bụ nzọụkwụ abụọ.Nke mbụ, ethyl carbamate na DMF diformaldehyde acetals na-etolite etiti Nn-dimethyl-n-ethoxy-formamidine.Nke abụọ, otu amino na phenylhydrazine na-egbutu carbon na foramidine, nke na-efunahụ -N (CH3).Mgbe ahụ, amonia na mgbanaka benzene dị nso na phenylhydrazine na-awakpo carbon na carbon Group, na-eme oxygen anion, na otu ụzọ electrons na oxygen na-agbada, na-efunahụ otu ethoxy, wee mepụta 1.2, 4-triazolone-5.
(II) Nkwadebe nke ogige heterocyclic site na mmeghachi omume nke amide acetal na amide
Nke a bụ usoro adịghị ọcha nke a kacha akọpụta n'ime iri afọ ndị na-adịbeghị anya.Omume nke amide acetal dabara na Grignard reagent, mana ọnọdụ mmeghachi omume nke amide acetal dị mfe ma dị nro.
Amide acetal nwere ìgwè abụọ na-arụ ọrụ, mmeghachi omume dị elu, na methyl na-arụ ọrụ, mmeghachi omume methylene na-emepụta amidine intermediates, nwere ike ịbụ mmeghachi omume ọzọ, mmechi mgbanaka, na Grignard reagent na mmeghachi omume methylene, naanị ịgbatị agbụ carbon, enweghị ike ịmeghachi mmeghachi omume ọzọ.Dịka ọmụmaatụ, njikọ nke ihe ndị na-emepụta furanochroone.
(3): amide acetal na hydroxyl, mmeghachi omume ngwakọta nke sulfhydryl iji mepụta oxygen, ogige heterocyclic sọlfọ.
Njikọ dị n'elu nke furohutanone bụ ezigbo ihe atụ nke ọgbọ acetal nke enamine derivatives na hydroxyl otu site na-ekewapụta ogwe osisi endolateral, na-ebute heteramine nwere oxy-contained:.Ihe atụ ọzọ: catechol na DMF -- DMA na-etolite mgbanaka nwere oxygen na ọnụnọ dichloromethane.
Mmeghachi omume nke DMF - DMA na o-mercaptoaniline nwere ike imepụta mgbanaka heterocyclic nwere sọlfọ, usoro mmeghachi omume bụ nke a.
Ọmụmụ ihe gbasara mmeghachi omume mmechi mgbanaka DMF-DMA na mmeghachi omume nkeonwe
(1) Batcho-Leimgruber indole njikọ
Nkwadebe nke ụdị Vindol dị iche iche sitere na o-nitrotoluene.
Usoro mmeghachi omume
Nke mbụ, dimethylformamide dimethylacetal, ion na-adịghị mma nke otu methoxy na-ahapụ ime ka ọ pụta ìhè n'etiti.A na-awakpo ya site na carboanions guzobere site na mwepu nke o-nitrotoluene methyl hydrogen wee tufuo methanol iji nweta enylamine ahụ a kpọtụrụ aha n'elu.Ngwaahịa nke usoro a, enamine, yiri alkene nke nwere ihe mgbakwunye eletrọn na-adọta na ihe inye onyinye eletrọn agbakwunyere n'akụkụ abụọ (Push-pull olefin bụ ike polar na-acha uhie uhie na-acha ọbara ọbara n'ihi nnukwu njikọ dị na molekul ahụ. nke mmeghachi omume, otu nitro na-ebelata ka ọ bụrụ otu amino, na-esote cyclization na mkpochapụ iji nweta ngwaahịa ikpeazụ.
(2) Foto ndị jikọtara ọnụ nke pyridine
(3) Nkwekọrịta nke ihe pyrazole