Entecavir CAS 142217-69-4 API Mgbochi HBV dị elu
Onye nrụpụta nwere ịdị ọcha dị elu yana ịdị mma kwụsie ike
Aha Chemical: Entecavir
OZI: 142217-69-4
A na-eji ọgwụ mgbochi nje na-agwọ ọrịa ịba ọcha n'anya B
API Ogo dị elu, mmepụta azụmahịa
Aha Chemical | Entecavir |
Ụdị okwu | 2-Amino-1,9-dihydro-9-[(1S,3R,4S) -4-hydroxy-3- (hydroxymethyl) -2-methylenecyclopentyl]-6H-purin-6-otu. |
Nọmba CAS | 142217-69-4 |
Nọmba CAT | RF-API80 |
Ọnọdụ Ahịa | Na Akụrụngwa, Mpụta Ihe ruru narị narị kilograms |
Usoro ihe omimi | C12H15N5O3 |
Ibu molekụla | 277.28 |
Ebe Na-agbaze | 249.0 ~ 252.0 ℃ |
Ụdị | Ruifu Chemical |
Ihe | Nkọwapụta |
Ọdịdị | White Crystalline ntụ ntụ |
njirimara IR | Ụdị nnabata infraed nke nlele ule ga-adarịrịrịrị na ọkọlọtọ ntụaka |
njirimara HPLC | Oge njide nke nlele ule dabara na nke ọkọlọtọ ntụaka |
pH | 5.5-7.5 |
Ntụgharị ngwa anya akọwapụtara | +24.0°-+28.0° (DMF: MeOH=1:1 C=1%) |
Ihe ndị emetụtara | |
Mgbakọta adịghị ọcha | ≤0.30% |
Oke adịghị ọcha otu | ≤0.10% |
Entiomer | ≤0.20% |
Ihe mgbaze fọdụrụnụ | |
Methanol | ≤0.30% |
Dichloromethane | ≤0.06% |
n-Hexane | ≤0.029% |
Tetrahydrofuran | ≤0.072% |
N, N-Dimethylformamide | ≤0.088% |
Toluene | ≤0.089% |
Ọdịnaya Mmiri | 5.8% ~ 6.5% |
Ihe fọdụrụ na mgbanye | ≤0.10% |
Ọla dị arọ | ≤20ppm |
Nyocha | 98.0% ~ 102.0% (C12H15N5O3 gbakọọ na anhydrous ndabere) |
Nha urughuru | D90: ≤100µm |
Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
Ojiji | API, ọgwụ mgbochi nje ejiri na ọgwụgwọ ọrịa ịba ọcha n'anya B |
ngwugwu: Kalama, Aluminom foil bag, kaadiboodu drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.
Entecavir bụ ọgbọ ọhụrụ nke guanine nucleoside analogues ọgwụ ọnụ maka ọgwụgwọ ọrịa ịba ọcha n'anya B (HBV), tumadi maka ọgwụgwọ nke ndị okenye nwere ọrịa viral replication na serum transaminase nọgidere na-abawanye, ma ọ bụ imeju anụ ahụ maka pathological ọrụ nke na-adịghị ala ala ịba ọcha n'anya B. , ugbu a bụ nje virus kacha ọsọ na nke kachasị ike, ọnụọgụ nucleoside kacha ala.Data na-egosi na dị iche iche na ndị ọrịa na-adịghị ala ala ịba ọcha n'anya B, gụnyere nucleoside naive na nucleoside mesoo na imeju cirrhosis ọrịa, na-eji nke ọma mbadamba entecavir na ọgwụgwọ nwere ike ịchịkwa ọrịa ngwa ngwa na mfe iru ọgwụgwọ nke eziokwu ọgwụgwụ, ya bụ nje ịba ọcha n'anya B enweghị atụ;site na nrubeisi na ọgwụgwọ, a bukwanu akụkụ nke ndị ọrịa nwere ike bịarute na njedebe nke ọgwụgwọ afọ ojuju, ya bụ e antigen serology ntughari, ụfọdụ ndị ọrịa nwere ike ọbụna iru mma maka ọgwụgwọ nke ọgwụgwụ, ya bụ elu antigen ọjọọ.