Entecavir Monohydrate CAS 209216-23-9 API Ụlọ ọrụ dị elu Antiviral Hepatitis B Ọrịa

Nkọwa dị mkpirikpi:

Aha Chemical: Entecavir Monohydrate

OZI: 209216-23-9

Ọdịdị: White ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ White Crystalline ntụ ntụ

A na-eji ọgwụ mgbochi nje na-agwọ ọrịa ịba ọcha n'anya B

API Ogo dị elu, mmepụta azụmahịa

Inquiry: alvin@ruifuchem.com

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Nkọwa ngwaahịa

Ngwaahịa ndị emetụtara

Mkpado ngwaahịa

Nkọwa:

Onye nrụpụta nwere ịdị ọcha dị elu yana ịdị mma kwụsie ike
Aha Chemical: Entecavir Monohydrate
OZI: 209216-23-9
Ejiri ya na ọgwụgwọ ọrịa ịba ọcha n'anya B
API Ogo dị elu, mmepụta azụmahịa

Njirimara kemịkalụ:

Aha Chemical	Entecavir monohydrate
Ụdị okwu	Entecavir Hydrate;9-[(1S,3R,4S)-4-Hydroxy-3- (hydroxymethyl) -2-methylenecyclopentyl] guanine Monohydrate
Nọmba CAS	209216-23-9
Nọmba CAT	RF-API79
Ọnọdụ Ahịa	Na Akụrụngwa, Mpụta Ihe ruru narị narị kilograms
Usoro ihe omimi	C12H17N5O4
Ibu molekụla	295.3
Ebe Na-agbaze	> 220 ℃
Njupụta	1.81
Ọnọdụ mbupu	Ebugara n'okpuru okpomọkụ gburugburu
Ụdị	Ruifu Chemical

Nkọwapụta:

Ihe	Nkọwapụta
Ọdịdị	White ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha kristal ntụ ntụ
Solubility	Soluble n'efu na Dimethylformamide, Soluble na Mmiri, Ethanol na Methanol
njirimara IR	Spectrum nke sample dabara na nke ọkọlọtọ ntụaka
njirimara HPLC	Oge njide nke nlele ule dabara na nke ọkọlọtọ ntụaka
Ọdịnaya mmiri (nke KF)	5.5% ~ 6.5%
Ntụgharị ngwa anya akọwapụtara	+24.0° ruo +30.0° (DMF: MeOH=1:1 C=1%) (na ihe na-eme ka mmiri na-ekpo ọkụ)
Ihe fọdụrụ na mgbanye	≤0.10%
Ihe ndị emetụtara
Furontecavir	≤0.10%
Entecavir 1-Epimer	≤0.10%
Entecavir 3-Epimer	≤0.10%
8-Methyoxy Entecavir	≤0.10%
Entecavir 4-Epimer	≤0.10%
8-Hydroxy Entecavir	≤0.10%
4-Dimethylsilyl Entecavir	≤0.10%
Njikọ metụtara Entecavir A	≤0.10%
Ọdịghị ọcha ọ bụla akọwapụtaghị	≤0.10%
Mgbakọta adịghị ọcha	≤0.30%
Ihe mgbaze fọdụrụnụ
Methanol	≤600ppm
Dichloromethane	≤300ppm
Ethyl acetate	≤1000ppm
Tetrahydrofuran	≤720ppm
Toluene	≤890ppm
Benzyl chloride	≤1000ppm
Benzyl mmanya	≤1000ppm
Oke Microbial
Ngụkọta ọnụ ọgụgụ ikuku	≤100cfu/g
Yist na ebu	≤10cfu/g
Escherichia Coli	E kwesịghị ịchọpụta
Ọla dị arọ	≤10ppm
Nyocha	98.0% ~ 102.0% (HPLC; na anhydrous ndabere)
Nha urughuru	95% nke ahụ kwesịrị ịdị n'ime 125um
Nlele ọkọlọtọ	Ụkpụrụ ụlọ ọrụ;Ọkọlọtọ United States Pharmacopoeia (USP).
Ojiji	A na-eji ọgwụ mgbochi nje na-agwọ ọrịa ịba ọcha n'anya B

Ngwungwu & Nchekwa:

ngwugwu: Kalama, Aluminom foil bag, kaadiboodu drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.

Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.

Uru:

Ajụjụ:

Ngwa:

Entecavir Monohydrate (CAS 209216-23-9) bụ ọgwụ mgbochi ọnụ nke ejiri na-agwọ ọrịa ịba ọcha n'anya B (HBV).Entecavir Monohydrate bụ analog nucleoside (karịa kpọmkwem, analọgụ guanine) nke na-egbochi ntụgharị ntụgharị, ntụgharị DNA na ntụgharị na vira.Ọ bụ ụdị ọhụrụ cyclopentyl acyl guanosine ọgwụ mgbochi ịba ọcha n'anya B nwere mmetụta ọgwụ ya dị ka Entecavir.A na-etinye ya n'ụlọ ọgwụ maka ọgwụgwọ ọrịa ịba ọcha n'anya nke B nke okenye, ebe enwere mmegharị nje na-arụ ọrụ, ịba ụba transaminase ALT ma ọ bụ ọnya nọ n'ọrụ gosipụtara site na histology imeju.Entecavir Monohydrate bụ onye na-egbochi HBV na-ahọrọ nke ọma, yana EC50 nke 3.75 nM na cell HepG2.Entecavir bụ ihe mgbochi ntụgharị transcriptase.Ọ na-egbochi nje ịba ọcha n'anya B (HBV) ịmụba ma na-ebelata ọnụọgụ nje dị n'ime ahụ.