Epalrestat CAS 82159-09-9 Dị Ọcha> Ụlọ ọrụ 99.5% (HPLC)
Shanghai Ruifu Chemical Co., Ltd bụ onye na-emepụta Epalrestat (CAS: 82159-09-9) nwere oke mma.Ruifu Chemical nwere ike ịnye nnyefe zuru ụwa ọnụ, ọnụahịa asọmpi, obere na nnukwu ọnụọgụ dị.Ịzụta Epalrestat,Please contact: alvin@ruifuchem.com
| Aha Chemical | Epalrestat |
| Ụdị okwu | Epalrest;ONO-2235;Ebe;Kinedak;Sorbistat;(5Z) -5-[(2E) -2-Methyl-3-phenyl-2-propen-1-ylidene] -4-oxo-2-thioxo-3-Thiazolidineacetic Acid;2-[(5Z) -5-[(E) -3-Phenyl-2-methylprop-2-enylidene] - 4-oxo-2-thioxo-3-thiazolidinyl] acetic acid;(E, E) -2-[5- (2-Methyl-3-phenyl-prop-2-enylidene) -4-oxo-2-sulfanylidene-thiazolidin-3-yl] acetic acid. |
| Ọnọdụ Ahịa | Na ngwaahịa, Mass Production |
| Nọmba CAS | 82159-09-9 |
| Usoro ihe omimi | C15H13NO3S2 |
| Ibu molekụla | 319.39 g/mol |
| Ebe Na-agbaze | 222.0 ruo 226.0 ℃ |
| Njupụta | 1.43±0.10 g/cm3 |
| Solubility | DMSO 2 mg/mL mmiri <1 mg/mL ethanol <1 mg/mL |
| Okpomọkụ nchekwa. | Ebe dị jụụ na akọrọ (-20 ℃) |
| COA & MSDS | Dị |
| Otu | API |
| Ụdị | Ruifu Chemical |
| Ihe | Ụkpụrụ nyocha | Nsonaazụ |
| Ọdịdị | Oroma ka ọcha ọbara ọbara kristal ntụ ntụ | Na-akwado |
| njirimara | Yiri oge njigide HPLC nke ọkọlọtọ | Gafe |
| Ebe Na-agbaze | 222.0 ruo 226.0 ℃ | 222.4 ~ 224.3 ℃ |
| Ọnwụ na ihicha | <0.50% | 0.04% |
| Ihe fọdụrụ na mgbanye | <0.20% | 0.03% |
| Ọla dị arọ (Pb) | ≤20ppm | <20ppm |
| Mgbakọta adịghị ọcha | ≤0.50% | 0.20% |
| Ụzọ ịdị ọcha / nyocha | > 99.5% (HPLC) | 99.8% |
| Spectrum infrared | Dabara na Ọdịdị | Na-akwado |
| Mmechi | A nwalela ngwaahịa a wee kwado nkọwa ndị enyere | |
ngwugwu:Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Chekwaa n'ime akpa mkpuchi mkpuchi n'ụlọ nkwakọba ihe dị jụụ ma kpọrọ nkụ (-20 ℃) pụọ na ihe na-ekwekọghị ekwekọ.Chebe site na ìhè na mmiri mmiri.
Mbupu:Nyefee n'ụwa niile site na FedEx / DHL Express.Nye nnyefe ngwa ngwa na ntụkwasị obi.
Kedu ka esi azụta?Biko kpọtụrụDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Ahụmịhe afọ 15?Anyị nwere ihe karịrị 15 afọ nke ahụmahụ na mmepụta na mbupụ nke a dịgasị iche iche nke elu mma pharmaceutical intermediates ma ọ bụ ezi kemịkal.
Isi ahịa?Na-ere ahịa ụlọ, North America, Europe, India, Korea, Japanese, Australia, wdg.
Uru?Ogo kachasị elu, ọnụ ahịa dị ọnụ ala, ọrụ ọkachamara na nkwado teknụzụ, nnyefe ngwa ngwa.
OgoNkwenye?Usoro njikwa mma siri ike.Ngwá ọrụ ọkachamara maka nyocha gụnyere NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, wdg.
Ihe atụ?Ọtụtụ ngwaahịa na-enye ihe nlele efu maka nyocha dị mma, ndị ahịa kwesịrị ịkwụ ụgwọ mbupu.
Nyocha ụlọ ọrụ?Nnabata nyocha ụlọ ọrụ.Biko mee oge oge tupu oge eruo.
MOQ?Enweghị MOQ.A na-anabata obere usoro.
Oge Mbuga ozi? Ọ bụrụ n'ime ngwaahịa, ekwenyere nnyefe ụbọchị atọ.
Ụgbọ njem?Site Express (FedEx, DHL), nke ikuku, site n'oké osimiri.
Akwụkwọ?Mgbe ọrụ ahịa gasịrị: COA, MOA, ROS, MSDS, wdg nwere ike ịnye.
Synthesis omenala?Nwere ike ịnye ọrụ nhazi ahaziri iche ka ọ dabara mkpa nyocha gị nke ọma.
Usoro ịkwụ ụgwọ?A ga-ebu ụzọ ziga akwụkwọ ọnụahịa Proforma mgbe nkwenye nke iwu, kpuchiri ozi ụlọ akụ anyị.Ịkwụ ụgwọ site na T/T (Telex Nyefee), PayPal, Western Union, wdg.
NJ UN 2811
WGK Germany 3
RTECS XJ5131855
Klas ihe egwu 6.1
Otu nkwakọ ngwaahịa II
Epalrestat (CAS: 82159-09-9) bụ ihe mgbochi aldose reductase nke abụọ ewebata n'ụwa niile yana nke mbụ ewepụtara na Japan.A na-egosi Epalrestat maka ọgwụgwọ ọrịa neuropathy mamịrị.A na-enyochakwa ya maka ọrịa mamịrị retinopathy na nephropathy.Epalrestat bụ ihe mgbochi aldose reductase nwere IC50 nke 72 nM.
Epalrestat na-egbochi Aldose Reductase (AR) na-etinye aka na njedebe ọnụego mgbanwe nke glucose na sorbitol n'okpuru ọnọdụ hyperglycemic.Aldose reductase bụ ebumnuche nke ọtụtụ nyocha ụlọ ọgwụ iji gwọọ neuropathy na-arịa ọrịa shuga na retinopathy.Epalrestat bụ ọgwụ akwadoro na Japan na India, eji agwọ ọrịa neuropathy mamịrị.
A na-eji Epalrestat egbochi, meziwanye ma na-agwọ ọrịa neuropathy mpụta (ọnụọgụ, mgbu), paresthesia vibrational, na ọrịa obi nke metụtara ọrịa shuga.
Epalrestat dị ka ọgwụ nnọchi anya ya na-ebelata mkpokọta intracellular nke fructose na sorbitol site na ngbanwe nke na-egbochi ọrụ aldose reductase, na-eweghachi Na +-K +-ATPase na ọrụ inositol, na-abawanye NO nguzobe na sel endothelial, na-egbochi protein kinase C ụzọ akara, endothelial cell adhesion, glucose cell adhesion. neutrophil mediated na endothelial adhesion factor nkwupụta ma na-ebelata ngwaahịa carboxymethyl lysine na ndị ọrịa mamịrị, si otú a na-agwọ ọrịa ndị dị ka ọrịa shuga na nsogbu ya.
